The effects of fetal hemoglobin levels on sickle cell anemia patients bone biochemistry / Fetal hemoglobin seviyesinin orak hücre anemisi hastalarının kemik biyokimyası üzerine etkisi

Abstract

Objective: The aim of this study was to evaluate the possible roles of fetal hemoglobin levels on bone parameters in sickle cell anemia (SCA) patients.Methods: Blood samples taken from 56 SS and 47 control totally 103 subjects were included in this research work according to their fetal hemoglobin levels. Fetal hemoglobin, bone mineral density, bone specific alkaline phosphatase, calcium, osteocalcin, 25-OH vitamin D and hematological parameters were measured and analyzed in the study.Results: Statistical analysis showed that, lower bone mineral density and biochemical bone parameters significantly correlated with low fetal hemoglobin levels at SCA patients.Conclusion: It was concluded that fetal hemoglobin level is a good index for bone status in sickle cell anemia patients.