The Effects of Ferulic Acid Against Oxidative Stress and Inflammation in Formaldehyde-Induced Hepatotoxicity

Abstract

This study was designed to elucidate the protective effects of ferulic acid (FA) on formaldehyde-induced hepatotoxicity by measuring some routine biochemical parameters, cytokine levels, and oxidative stress-related parameters in addition to YKL-40 in male Wistar albino rats. Tissue superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities, and tissue malondialdehyde (MDA) levels were measured. Also, serum YKL-40, TNF-α, IL-6, IL-1β, IL-8, total protein, albumin, total bilirubin concentrations, and AST, ALT, ALP, and LDH activities were measured. Histological specimens were examined in light microscopy. Formaldehyde significantly increased tissue MDA, and serum cytokine levels and also decreased activities of antioxidant enzymes. FA treatment decreased MDA and cytokine levels and increased activities of antioxidant enzymes. FA also alleviated degeneration due to formaldehyde toxicity. We suggested that FA can be used as a promising hepatoprotective agent against formaldehyde toxicity because of the obvious beneficial effects on oxidative stress parameters.

Boletus aereus protects against acute alcohol-induced liver damage in the C57BL/6 mouse via regulating the oxidative stress-mediated NF-κB pathway

“…YKL40 is highly expressed in chronic liver disease patients with liver fibrosis and cirrhosis (Sarma et al 2012). As reported, the link between YKL-40 and ALD is mediated by ROS (Gerin et al 2016). PAI-1 inhibits fibrin degradation, promotes fibrin deposition on blood vessel walls, and stimulates smooth muscle cell proliferation (Hasenstab et al 2000).…”

Flavonoids, Sterols and Lignans from Cochlospermum vitifolium and Their Relationship with Its Liver Activity

“…On the other hand, coniferyl alcohol ( 7 ) had a moderated anti-hepatitis B virus (HBV) activity [ 32 ]. Ferulic acid ( 9 ) had an in vivo hepato-protective effect against the CCl 4 - and formaldehyde-induced hepatotoxicity [ 33 ] and also a capacity to inhibit the development of hepatic fibrosis by activation of Hepatic Stellate Cells (HSCs) in the presence of liver damage [ 34 ]. Vomifoliol ( 10 ) showed moderate activity against human hepatocarcinoma Hep3B cells [ 35 ].…”

Ameliorative effect of ferulic acid on gentamicininduced nephrotoxicity in a rat model; role of antioxidant effects

“…Ferulic acid is a natural compound with a phenolic group which is found mainly in citrus, rice, coffee, etc. In numerous studies, many roles have been identified for this substance, including anticancer, nephroprotective, hepatoprotective and anti-inflammatory activity (25). Sompong et al demonstrated the inhibitory effect of ferulic acid in glycation and oxidative damage of proteins in 2016 (26).…”

“…Accordingly, Gerin et al found that ferulic acid could play an inhibitory role in liver damage due to oxidative stress induced by formaldehyde. Having hydroxyl and phenoxyl groups in its structure, ferulic acid can neutralize free radicals (25). Furthermore, it responds to cellular stress and oxidative damage by increasing the level of antioxidant systems such as SOD, GPx and CAT enzymes and decreasing the expression of cytotoxic enzymes (11).…”