The effects of electromyostimulation application timing on denervated skeletal muscle atrophy

Koh, Eun Sil; Kim, Hee Chan; Lim, Jae‐Young

doi:10.1002/mus.25656

Cited by 9 publications

(10 citation statements)

References 52 publications

(70 reference statements)

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“…The reason may be that the significant lower limb muscle atrophy caused by spinal cord injury occurs 8 weeks after the injury, or even longer. Therefore, the results of this experiment are negative ( Koh et al, 2017 ).…”

Section: Resultsmentioning

confidence: 88%

Epigallocatechin-3-gallate selenium nanoparticles for neuroprotection by scavenging reactive oxygen species and reducing inflammation

Wang

Luo

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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Purpose: Spinal cord injury (SCI) is a severely crippling injury. Scavenging reactive oxygen species (ROS) and suppressing inflammation to ameliorate secondary injury using biomaterials has turned into a promising strategy for SCI recuperation. Herein, epigallocatechin-3-gallate selenium nanoparticles (EGCG-Se NP) that scavenge ROS and attenuate inflammation were used for neuroprotection in SCI.Methods: EGCG-Se NP were arranged using a simple redox framework. The size, morphology, and chemical structure of the EGCG-Se NP were characterized. The protective effect of EGCG-Se NP for neuroprotection was examined in cell culture and in an SCI rat model.Results: EGCG-Se NP could promptly scavenge excess ROS and safeguard PC12 cells against H2O2-induced oxidative harm in vitro. After intravenous delivery in SCI rats, EGCG-Se NP significantly improved locomotor capacity and diminished the injury region by safeguarding neurons and myelin sheaths. Component studies showed that the main restorative impact of EGCG-Se NP was due to their ROS-scavenging and anti-inflammatory properties.Conclusion: This study showed the superior neuroprotective effect of EGCG-Se NP through ROS sequestration and anti-inflammatory capabilities. EGCG-Se NP could be a promising and effective treatment for SCI.

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Section: Resultsmentioning

confidence: 88%

Epigallocatechin-3-gallate selenium nanoparticles for neuroprotection by scavenging reactive oxygen species and reducing inflammation

Wang

Luo

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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“…However, the denervation process includes a conversion of slow- to fast-twitch muscle fibers accompanied with a denervation induced muscle atrophy that leads to an adaptation of myosin heavy chain (MHC) expression in which MHC content decreases and the relative proportions of MHC isoforms change. As a result, hybrid fibers expressing multiple MHC isoforms increases in denervated muscle [14] . Electrostimulation elicits muscle contraction with the intent of minimizing muscle atrophy and replacing neural input during denervation [14] .…”

Section: Discussionmentioning

confidence: 99%

“…As a result, hybrid fibers expressing multiple MHC isoforms increases in denervated muscle [14] . Electrostimulation elicits muscle contraction with the intent of minimizing muscle atrophy and replacing neural input during denervation [14] . The rationale for using electrical stimulation of denervated muscles is to maintain contractility as the most important factor in regulating the properties of muscle fibers [14] .…”

Section: Discussionmentioning

confidence: 99%

“…Electrostimulation elicits muscle contraction with the intent of minimizing muscle atrophy and replacing neural input during denervation [14] . The rationale for using electrical stimulation of denervated muscles is to maintain contractility as the most important factor in regulating the properties of muscle fibers [14] . By eliciting muscle contractions, the muscle is activated and “strengthened” and can at least regain MT to a limited extent.…”

Section: Discussionmentioning

confidence: 99%

“…Optimal stimulation time and the most effective intensity needed to detect morphological change in the upper extremity musculature has yet to be proven. At the molecular level, the altered expression of myosin heavy chain isoforms following denervation could be reversed by electrical stimulation [14] .…”

Section: Introductionmentioning

confidence: 99%

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Electrical stimulation alters muscle morphological properties in denervated upper limb muscles

Bersch

Fridén

2021

eBioMedicine

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Background Damage to lower motor neuron causes denervation and degeneration of the muscles affected. Experimental and clinical studies of muscle denervation in lower extremities demonstrated that direct electrical stimulation (ES) of muscle can prevent denervation atrophy and restore contractility. The aim of this study was to identify possible myogenic effect of ES on denervated forearm and hand muscles in persons with spinal cord injury (SCI) and tetraplegia. Methods This prospective interventional study with repeated measurement design included 22 patients aged 48·6 (± 15·7), 0·25 (0·1/46) years after spinal cord lesion, AIS A-D. In each patient, two electrophysiologically-confirmed denervated muscles in the hand and forearm were analyzed – one extrinsic (Extensor Carpi Ulnaris - ECU) and one intrinsic (1st Dorsal Interosseus - IOD1). Muscles were stimulated for 33 min, five times per week over a 12-weeks period. Using ultrasonography (USG), muscle thickness (MT) and pennation angle (PA) of these muscles were determined at start and end of the stimulation period. Findings MT of IOD1 increased from 6·3 mm (± 3·2 mm) to 9·2 mm (± 2·4 mm) ( p = 0·004) and the PA from 5·5° (± 3·0°) to 11° (± 2·2°) ( p = 0·001). The corresponding values for the ECU were 5·5 mm (± 2·5 mm) to 7·0 mm (± 2·2 mm) ( p = 0·039) and 5·5° (± 3·4°) to 9·4° (± 3·8°) ( p = 0·005), respectively. The correlation of MT between baseline and completion was r = 0·58 ( p = 0·037) for the ECU and r = 0·63 ( p = 0·008) for the IOD1. Interpretation 12 weeks of direct muscle stimulation increases the MT and PA of the denervated intrinsic and extrinsic hand muscles studied. Funding Swiss Paraplegic Centre, Switzerland

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Heme oxygenase‐1 therapy attenuates muscle atrophy following global brachial plexus avulsion in juvenile rats

Qin,

Rui,

Lao

2023

Muscle and Nerve

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Introduction/AimsBrachial plexus injury can seriously affect distal target muscle function, and long‐term denervation leads to irreversible structural damage. In the present study, we examined the effect of hemin, a heme oxygenase‐1 (HO‐1) inducer, on intrinsic forepaw muscle atrophy induced by pan‐plexus injury in juvenile rats, as well as its underlying mechanism.MethodsA global brachial plexus avulsion (GBPA) model of rat was established, and thirty 6‐wk‐old male rats were randomly divided into five groups: control, GBPA plus scramble small intering RNA (siRNA), GBPA plus scramble siRNA plus hemin, GBPA plus HO‐1 siRNA, and GBPA plus HO‐1 siRNA plus hemin. Hemin (50 mg/kg) was administered intraperitoneally once daily and the siRNA (5 μg) was injected intramuscularly twice a week. Intrinsic forepaw muscles were used for analysis. Myofiber cross‐sectional area (CSA), capillary‐to‐fiber ratio (C/F), and fiber‐type composition were assessed. The levels of inflammatory factors, ubiquitin‐protein ligases, and autophagy‐related proteins were also measured.ResultsWe found that hemin treatment could effectively ameliorate denervated intrinsic forepaw muscle atrophy and suppress type I to II myofiber‐type conversion. Hemin treatment failed to prevent muscle capillary loss after denervation. The levels of inflammatory factors (tumor necrosis factor alpha [TNFα] and interleukin 6 [IL‐6]), ubiquitin‐protein ligases (MuRF‐1 and MAFbx), and autophagy‐related proteins (BNIP3 and LC3B‐II/I ratio) were increased by denervation and HO‐1 therapy attenuated the increment.DiscussionUpregulation of HO‐1 might potentially be an effective strategy to alleviate denervation‐related muscle atrophy and might be a promising adjunctive treatment to improve hand function in children with pan‐plexus injury.

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The effects of electromyostimulation application timing on denervated skeletal muscle atrophy

Abstract: These results indicate that immediate EMS is more effective than delayed EMS for aiding recovery of denervation-induced MHC changes. Muscle Nerve 56: E154-E161, 2017.

Cited by 9 publications

References 52 publications

Epigallocatechin-3-gallate selenium nanoparticles for neuroprotection by scavenging reactive oxygen species and reducing inflammation

Epigallocatechin-3-gallate selenium nanoparticles for neuroprotection by scavenging reactive oxygen species and reducing inflammation

Electrical stimulation alters muscle morphological properties in denervated upper limb muscles

Heme oxygenase‐1 therapy attenuates muscle atrophy following global brachial plexus avulsion in juvenile rats

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