The Effects of Eggs in a Plant-Based Diet on Oxidative Stress and Inflammation in Metabolic Syndrome

Thomas, Minu; Huang, Lindsey; García, Christopher; Sakaki, Junichi; Blesso, Christopher N.; Chun, Ock K.; Fernández, María Luz

doi:10.3390/nu14122548

Cited by 8 publications

(10 citation statements)

References 44 publications

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“…Two publications reported the results of a crossover RCT where 24 participants with MetS consumed either 2 eggs/day versus yolk-free egg substitute plus 70 g spinach/day for 4 weeks [ 72 , 73 ]. As well as reporting similar metabolic changes to other RCT (higher HDL-c, larger HDL-c particles, higher carotenoids, improved antioxidant status), there was a modest, statistically significant reduction in weight and body mass index.…”

Section: Results: Risk Assessmentmentioning

confidence: 99%

“…RCT which provided 2–6 eggs daily in healthy [ 75 , 119 , 120 ] and at risk [ 27 ] groups of participants confirmed that eggs do not raise TMAO levels. Similarly, RCT based on daily egg intake found no adverse effects on markers of inflammation or oxidative stress [ 72 , 73 , 120 ]. Indeed, adding whole eggs or egg white to a glucose dietary challenge in prediabetic men attenuated post-prandial oxidative stress [ 121 ].…”

Section: Discussion Of Benefits Vs Risksmentioning

confidence: 99%

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Eggs: Healthy or Risky? A Review of Evidence from High Quality Studies on Hen’s Eggs

Myers¹,

Ruxton²

2023

Nutrients

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Hen’s eggs (from Gallus gallus domesticus) provide choline, folate, vitamin D, iodine, B vitamins and high-quality protein and are no longer viewed by national bodies as a risk factor for hypercholesterolaemia and cardiovascular disease (CVD). Yet, questions remain about the benefits and risks of eating eggs regularly. This review evaluates recent high-quality evidence from randomised controlled trials (RCT) and meta-analyses of observational studies and considers new areas of interest, such as weight management, protein metabolism, allergy risk and sustainability. In several RCT, eggs increased muscle protein synthesis and lowered fat mass, which could support optimal body composition. Eggs within a meal improved satiety, which could translate into lower energy intakes, although more RCT are needed. In observational studies, higher egg consumption was associated with a null effect or a modest reduced risk of CVD. For type 2 diabetes (T2D) incidence and risk of CVD in people with T2D, there were inconsistencies between observational and RCT data, with the former noting positive associations and the latter seeing no effect of higher egg intake on markers of T2D and CVD. Sustainability metrics suggest that eggs have the lowest planetary impact amongst animal proteins. To lower allergy risk, earlier introduction of eggs into weaning diets is warranted. In conclusion, the balance of evidence points to eggs being a nutritious food suggesting there are broad health benefits from including eggs in the diet at intakes higher than that currently consumed by European populations.

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Section: Results: Risk Assessmentmentioning

confidence: 99%

Section: Discussion Of Benefits Vs Risksmentioning

confidence: 99%

Eggs: Healthy or Risky? A Review of Evidence from High Quality Studies on Hen’s Eggs

Myers¹,

Ruxton²

2023

Nutrients

View full text Add to dashboard Cite

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“…Our results also exhibited that higher OBS was related to lower MetS severity. The degree of oxidative stress depends on the severity of MetS (51). Previous studies have shown that participants with higher MetS severity scores tended to have less physical activity, a pro-inflammatory dietary pattern, and lower adherence to the Mediterranean diet (52).…”

Section: Discussionmentioning

confidence: 99%

Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome

Xu,

Lei,

Chu

et al. 2024

Front. Endocrinol.

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BackgroundThe oxidative balance score (OBS), an encompassing scoring mechanism for assessing oxidative stress, is formulated based on nutritional and lifestyle components. The emergence of metabolic syndrome (MetS) is intricately linked to oxidative stress. Nonetheless, the correlation between OBS and MetS displays variability within distinct cohorts.ObjectiveWe worked on the relationships between OBS and the risk of MetS, MetS severity, and all-cause mortality of MetS patients.MethodsA total of 11,171 adult participants were collected from the U.S. National Health Examination Survey (NHANES) 2007-2018. Employing survey-weighted logistic models, we evaluated the relationship between OBS and MetS risk. Furthermore, survey-weighted linear models were utilized to investigate the connection between OBS and MetS severity. Among the participants, 3,621 individuals had their survival status recorded, allowing us to employ Cox proportional hazards regression models in order to ascertain the association between OBS and the all-cause mortality within the subset of individuals with MetS. The OBS (where a higher OBS signified an increased prevalence of anti- or pro-oxidant exposures) weighed the 20 factors, while the MetS severity score weighed the five factors.ResultsAfter multivariable adjustment, individuals with elevated OBS were found to exhibit a decreased susceptibility to MetS [odds ratio (OR) 0.95; 95% CI 0.94-0.96]. The adjusted OR was 0.42 (95% CI 0.33-0.53) for MetS risk in the fourth OBS quartile compared with those in the first OBS quartile (P for trend < 0.001). A one-unit increase in OBS was linked to a 3% reduction in MetS severity score by 3% (mean difference, -0.03; 95% CI, -0.04 to -0.03). Moreover, increased OBS correlated with decreased hazard of all-cause mortality risk among MetS subjects (adjusted hazard ratio, 0.95; 95% CI, 0.93-0.98). These associations retained their strength even subsequent to the introduction of sensitivity analyses. There existed a statistically significant negative correlation between diet/lifestyle OBS and both MetS risk as well as MetS severity.ConclusionsAn inverse correlation was observed between OBS and the susceptibility to MetS, MetS severity, and all-cause mortality of MetS patients. Health outcomes for MetS patients were positively related to antioxidant diets and lifestyles.

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“…Dietary intervention studies in people with MetS indicate the potential therapeutic potential of carotenoids and polyphenols [59][60][61][62][63][64]; however, the results of clinical trials have been inconsistent [65][66][67]. Consuming a balanced and bioactive-rich diet low in carbohydrates and saturated fat is critical to managing metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Plasma Carotenoids and Polyphenols and Their Association with MetS: The Need for Nutritional Interventions

et al. 2023

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Metabolic syndrome (MetS) is characterized by increased pro-oxidative stress and a chronic inflammation state and their consequent alterations. Several studies have highlighted the protective effect of carotenoids and polyphenols in MetS patients. This study aimed to evaluate the plasma level of selected carotenoids and polyphenols and to determine their relationship with MetS severity, MetS components, and inflammatory markers in Polish adults with metabolic disorders. It was designed as a cross-sectional study. The final study group comprised 275 adults, including 158 women and 117 men. Data were collected on the frequency of consumption of selected food groups. Anthropometric measurements and blood samples were taken to determine the concentration of carotenoids, polyphenols, and indicators (parameters) of metabolic disorders. Plasma concentrations of selected carotenoids and polyphenols were low in adults with MetS. The highest concentrations of carotenoids and polyphenols in the blood were observed for lutein and phenolic acids (including gallic and p-coumaric acids). Nevertheless, a correlation was found between the individual bioactive compounds and MetS components. In terms of the lipid profile, our study showed that the plasma of the selected carotenoids and polyphenols positively correlated with HDL cholesterol (zeaxanthin; total carotenoids), LDL cholesterol (chlorogenic acid), triglycerides (lycopene), and the total cholesterol (kaempferol). We found that the level of CRP as a marker of inflammation negatively correlated with the concentration of zeaxanthin. In our study group, no relationship was found between the dietary antioxidant intensity and the variables studied, which may be attributed to the low frequency of consumption of the sources of bioactive compounds, such as carotenoids and polyphenols, but also to the metabolic disorders. Further research is needed to determine whether these associations are causally related to the metabolic syndrome or are a result of the pathologies of the syndrome or improper diet with a low intake of vegetables and fruit.

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The Effects of Eggs in a Plant-Based Diet on Oxidative Stress and Inflammation in Metabolic Syndrome

Cited by 8 publications

References 44 publications

Eggs: Healthy or Risky? A Review of Evidence from High Quality Studies on Hen’s Eggs

Eggs: Healthy or Risky? A Review of Evidence from High Quality Studies on Hen’s Eggs

Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome

Plasma Carotenoids and Polyphenols and Their Association with MetS: The Need for Nutritional Interventions

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