The effects of crocin (active contstituent of saffron) treatment on brain antioxidant enzyme mRNA levels in diabetic rats / Diyabetik ratlarda safranın aktif içeriği olan krosin tedavisinin beyindeki antioksidan enzimlerin mRNA seviyeleri üzerine etkisi

Altınöz, Eyüp; Ekici, Cemal; Özyazgan, Berna; Çiğremiş, Yılmaz

doi:10.1515/tjb-2016-0018

Cited by 5 publications

(1 citation statement)

References 16 publications

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“…Also, Altınöz et al demonstrated that consumption of crocin at the dose of 20 mg/kg for 21 days could modulate mRNA expression of antioxidant enzymes (CAT, GPX, and SOD). Further consumption of crocin can treat the STZ-induced oxidative stress in the brain of diabetic rats (19). The radical scavenging activity of crocin has also been shown in several in vitro models (20).…”

Section: Discussionmentioning

confidence: 94%

The Effect of Endurance Training with Crocin Consumption on the Levels of AMPK and NRF1 Gene Expression in the Soleus Muscles of Diabetic Rats

Peyravi

Nayeri

Yazdanpanahi

et al. 2021

Ann Mil Health Sci Res

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Background: Exercise training and crocin, as a herbal antioxidant, help improve metabolism and insulin sensitivity in type 2 diabetes mellitus (T2D). AMP-activated protein kinase (AMPK) and nuclear respiratory factor 1 (NRF1) involve in the mitochondrial biogenesis pathway and diabetes control. Objective: This study aimed to investigate the effects of high-intensity interval training (HIIT), and low intensity continued training (LICT) in combination with crocin consumption on AMPK and NRF1 gene expression in the muscle tissue of diabetic rats. Methods: In this experimental study, 56 adult rats were divided into eight groups (n = 7), including diabetic (crocin utilization, HIIT, LICT, HIIT with crocin, LICT with crocin, control, sham groups) and healthy control group. The HIIT and LICT groups performed five sessions of training per week for eight weeks, and the crocin consumption groups received 25 mg/kg of crocin daily for eight weeks. Moreover, AMPK and NRF1 genes expression levels were evaluated in different groups using real-time polymerase chain reaction (RT-PCR). Results: According to our results, while induction of diabetes significantly decreased the levels of NRF1 and AMPK gene expression (P ≤ 0.05), training and crocin consumption significantly increased the levels of AMPK and NRF1 gene expression (P ≤ 0.05). Conclusions: It appears that crocin consumption along with HIIT improves diabetes symptoms through AMPK and NRF1 mechanism in diabetic rats.

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Section: Discussionmentioning

confidence: 94%

The Effect of Endurance Training with Crocin Consumption on the Levels of AMPK and NRF1 Gene Expression in the Soleus Muscles of Diabetic Rats

Peyravi

Nayeri

Yazdanpanahi

et al. 2021

Ann Mil Health Sci Res

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Study the effect of crocin on the expression of PAX2 and WT1 genes in renal tissues and serum levels of NGAL and cystatin C in cadmium-treated rats

Omidali

Korani

2021

Mol. Cell. Toxicol.

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Elucidation of Antioxidant and Neuroprotective Potential of Fucoxanthin Isolated from Brown Seaweed Sargassum oligocystum

Thom

Thu

et al. 2023

Preprint

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Fucoxanthin belonging to the carotenoid family has different bioactive properties as anti-oxidant, anti-obesity, anti-diabetic, and anti-cancer effects. This study presents the results of the extraction and purification of fucoxanthin from Sargassum olygocystum Montagne, 1845 using thin-layer chromatography, column chromatography, and high-performance liquid chromatography. Furthermore, this study demonstrated the antioxidant activities, expression of antioxidant enzymes, and inhibition of acetylcholinesterase (AChE) of fucoxanthin. The chemical structure, molecular formula (C42H58O6), and molecular weight (658) of fucoxanthin were determined by nuclear magnetic resonance spectroscopy. Fucoxanthin isolated from S. olygocystum showed no cytotoxic effects, moreover, it showed potent antioxidant activity as assessed by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method (with an IC50 value of 3.42 ± 0.15 mg mL− 1), and AchE inhibitory activity (with an IC50 value of 130.12 ± 6.65 µg mL− 1). At concentrations of 50 and 100 µg mL− 1, fucoxanthin protected against amyloid β-protein fragment 25–35 - induced neurotoxicity on the C6 neuronal cell line with the survival of C6 cells higher than 81.01 and 80.98%, respectively, compared to the control group (59%). Moreover, antioxidant enzyme activity and quantitative PCR analysis revealed that the neuroprotective effect of fucoxanthin, was possibly due to not only regulation of gene expression of antioxidant enzyme (CAT and GPx), ER pathway (caspase-3 and Bax) but also promoting expression of genes involved in PI3K/Akt signaling (GSK-3β), autophagy (p62 and ATG5) and the biosynthesis of ACh (VAChT and ChAT). Therefore, fucoxanthin extracted from the Sargassum olygocystum is a potential feedstock source for the production of health foods with neuroprotective effects.

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The effects of crocin (active contstituent of saffron) treatment on brain antioxidant enzyme mRNA levels in diabetic rats / Diyabetik ratlarda safranın aktif içeriği olan krosin tedavisinin beyindeki antioksidan enzimlerin mRNA seviyeleri üzerine etkisi

Cited by 5 publications

References 16 publications

The Effect of Endurance Training with Crocin Consumption on the Levels of AMPK and NRF1 Gene Expression in the Soleus Muscles of Diabetic Rats

The Effect of Endurance Training with Crocin Consumption on the Levels of AMPK and NRF1 Gene Expression in the Soleus Muscles of Diabetic Rats

Study the effect of crocin on the expression of PAX2 and WT1 genes in renal tissues and serum levels of NGAL and cystatin C in cadmium-treated rats

Elucidation of Antioxidant and Neuroprotective Potential of Fucoxanthin Isolated from Brown Seaweed Sargassum oligocystum

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