The effects of carbon disulfide on the reproductive system of the male rat

The effects of carbon disulfide on male sexual function and semen quality

“…Similar results were obtained in the study, a significant effect of CS 2 exposure on libido and potency by investigating the sexual function and reproductive outcome of 160 male viscose rayon workers exposed to CS 2 and 79 other workers who were not exposed to any toxic agent in working environment (Vanhoorne et al, 1994). Meanwhile, one analysis of animal experiments revealed that CS 2 exposure produced significant alterations in sexual behavior in rats (Tepe and Zenick, 1984;Zenick et al, 1984). In the present study, sexual dysfunction was significantly higher in the exposed group when compared to the control.…”

The effects of carbon disulfide on male sexual function and semen quality

“…Similar results were obtained in the study, a significant effect of CS 2 exposure on libido and potency by investigating the sexual function and reproductive outcome of 160 male viscose rayon workers exposed to CS 2 and 79 other workers who were not exposed to any toxic agent in working environment (Vanhoorne et al, 1994). Meanwhile, one analysis of animal experiments revealed that CS 2 exposure produced significant alterations in sexual behavior in rats (Tepe and Zenick, 1984;Zenick et al, 1984). In the present study, sexual dysfunction was significantly higher in the exposed group when compared to the control.…”

How to Differentiate General Toxicity-Related Endocrine Effects from Endocrine Disruption: Systematic Review of Carbon Disulfide Data

“…The effect was accompanied by neurofilamentous accumulation [ 58 , 59 , 68 , 69 ] and myelin thinning [ 65 ]. In addition, an adverse effect on mating behavior (increased latency to mount and to ejaculation) was described in rats exposed for 10 weeks to CS 2 at 1896 mg/m 3 [ 70 , 71 ].…”

A Review of Developmental and Reproductive Toxicity of CS2and H2S Generated by the Pesticide Sodium Tetrathiocarbonate

“…Tepe and Zenick ( ): CS 2 was administered in air to adult male Long‐Evans Hooded rats at 0 ( n = 29), 350, and 600ppm ( n = 15/dose) for 10 weeks (5 hr/day, 5 days/week). Experiment #1 : After 10 weeks of exposure, the rats were terminated and LH, FSH, and T levels were assessed; testes were examined for histopathology and sperm count.…”

“…Other developmental or reproductive effects were observed at higher doses in rat and rabbit inhalation studies where neurobehavioral assessments were not performed (Table ; Tabacova etal., , ,; Tepe and Zenick, ; Zenick etal., ; Denny, ; Holson, ). In general, dams had indications of toxicity (increases in: clinical signs, preimplantation loss, gestation length, total litter loss, and number of stillborn per litter; decreases in: body weight/weight gain during gestation and lactation, food intake during gestation).…”

“…CS 2 was highly toxic to the male rat reproductive system (changes in copulatory behavior, ↓semen sperm counts, ↓body weight, ↓epididymal sperm counts, ↓T levels) after inhalation exposure (Tepe and Zenick, ; Zenick etal., ). However, the NOEL of 350ppm was higher than was observed in dams or fetuses/pups showing that male rats are less sensitive to CS 2 via inhalation for the limited parameters tested.…”

The effects of carbon disulfide on male sexual function and semen quality

“…Similar results were obtained in the study, a significant effect of CS 2 exposure on libido and potency by investigating the sexual function and reproductive outcome of 160 male viscose rayon workers exposed to CS 2 and 79 other workers who were not exposed to any toxic agent in working environment (Vanhoorne et al, 1994). Meanwhile, one analysis of animal experiments revealed that CS 2 exposure produced significant alterations in sexual behavior in rats (Tepe and Zenick, 1984;Zenick et al, 1984). In the present study, sexual dysfunction was significantly higher in the exposed group when compared to the control.…”

How to Differentiate General Toxicity-Related Endocrine Effects from Endocrine Disruption: Systematic Review of Carbon Disulfide Data

“…The effect was accompanied by neurofilamentous accumulation [ 58 , 59 , 68 , 69 ] and myelin thinning [ 65 ]. In addition, an adverse effect on mating behavior (increased latency to mount and to ejaculation) was described in rats exposed for 10 weeks to CS 2 at 1896 mg/m 3 [ 70 , 71 ].…”

A Review of Developmental and Reproductive Toxicity of CS2and H2S Generated by the Pesticide Sodium Tetrathiocarbonate

“…Tepe and Zenick ( ): CS 2 was administered in air to adult male Long‐Evans Hooded rats at 0 ( n = 29), 350, and 600ppm ( n = 15/dose) for 10 weeks (5 hr/day, 5 days/week). Experiment #1 : After 10 weeks of exposure, the rats were terminated and LH, FSH, and T levels were assessed; testes were examined for histopathology and sperm count.…”

“…Other developmental or reproductive effects were observed at higher doses in rat and rabbit inhalation studies where neurobehavioral assessments were not performed (Table ; Tabacova etal., , ,; Tepe and Zenick, ; Zenick etal., ; Denny, ; Holson, ). In general, dams had indications of toxicity (increases in: clinical signs, preimplantation loss, gestation length, total litter loss, and number of stillborn per litter; decreases in: body weight/weight gain during gestation and lactation, food intake during gestation).…”

“…CS 2 was highly toxic to the male rat reproductive system (changes in copulatory behavior, ↓semen sperm counts, ↓body weight, ↓epididymal sperm counts, ↓T levels) after inhalation exposure (Tepe and Zenick, ; Zenick etal., ). However, the NOEL of 350ppm was higher than was observed in dams or fetuses/pups showing that male rats are less sensitive to CS 2 via inhalation for the limited parameters tested.…”

The effects of carbon disulfide on male sexual function and semen quality

“…Similar results were obtained in the study, a significant effect of CS 2 exposure on libido and potency by investigating the sexual function and reproductive outcome of 160 male viscose rayon workers exposed to CS 2 and 79 other workers who were not exposed to any toxic agent in working environment (Vanhoorne et al, 1994). Meanwhile, one analysis of animal experiments revealed that CS 2 exposure produced significant alterations in sexual behavior in rats (Tepe and Zenick, 1984;Zenick et al, 1984). In the present study, sexual dysfunction was significantly higher in the exposed group when compared to the control.…”

How to Differentiate General Toxicity-Related Endocrine Effects from Endocrine Disruption: Systematic Review of Carbon Disulfide Data

“…The effect was accompanied by neurofilamentous accumulation [ 58 , 59 , 68 , 69 ] and myelin thinning [ 65 ]. In addition, an adverse effect on mating behavior (increased latency to mount and to ejaculation) was described in rats exposed for 10 weeks to CS 2 at 1896 mg/m 3 [ 70 , 71 ].…”

A Review of Developmental and Reproductive Toxicity of CS2and H2S Generated by the Pesticide Sodium Tetrathiocarbonate

“…Tepe and Zenick ( ): CS 2 was administered in air to adult male Long‐Evans Hooded rats at 0 ( n = 29), 350, and 600ppm ( n = 15/dose) for 10 weeks (5 hr/day, 5 days/week). Experiment #1 : After 10 weeks of exposure, the rats were terminated and LH, FSH, and T levels were assessed; testes were examined for histopathology and sperm count.…”

“…Other developmental or reproductive effects were observed at higher doses in rat and rabbit inhalation studies where neurobehavioral assessments were not performed (Table ; Tabacova etal., , ,; Tepe and Zenick, ; Zenick etal., ; Denny, ; Holson, ). In general, dams had indications of toxicity (increases in: clinical signs, preimplantation loss, gestation length, total litter loss, and number of stillborn per litter; decreases in: body weight/weight gain during gestation and lactation, food intake during gestation).…”

“…CS 2 was highly toxic to the male rat reproductive system (changes in copulatory behavior, ↓semen sperm counts, ↓body weight, ↓epididymal sperm counts, ↓T levels) after inhalation exposure (Tepe and Zenick, ; Zenick etal., ). However, the NOEL of 350ppm was higher than was observed in dams or fetuses/pups showing that male rats are less sensitive to CS 2 via inhalation for the limited parameters tested.…”