The effects of caloric restriction on <scp>F</scp>etuin‐<scp>A</scp> and cardiovascular risk factors in rats and humans: a randomized controlled trial

Choi, Kyung Mook; Han, Kyung Ah; Ahn, Hee Jung; Lee, So Young; Hwang, Soon Young; Kim, Baek-hui; Hong, Ho Cheol; Choi, Hee Youn; Yang, Sae Jeong; Yoo, Hye Jin; Baik, Sei Hyun; Choi, Dong Seop; Min, Kyung Up

doi:10.1111/cen.12076

Cited by 57 publications

(47 citation statements)

References 30 publications

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“…Consistent with these findings, many epidemiologic studies have observed elevated levels of circulating fetuin-A in obesity and related metabolic diseases including type 2 DM, metabolic syndrome, and NAFLD [31,32,33]. Our previous study showed a significant decrease in circulating fetuin-A levels after 12 weeks of caloric restriction that was accompanied by improvements in visceral fat area, blood pressure, lipid profiles, and glucose levels [34]. In the European Prospective Investigation into Cancer and Nutrition-Potsdam study, plasma fetuin-A levels were positively associated with the incidence of diabetes after adjustment for sex, body mass index, waist circumference, and lifestyle risk factors during 7 years of follow-up [35].…”

Section: Fetuin-asupporting

confidence: 76%

Hepatokines as a Link between Obesity and Cardiovascular Diseases

Yoo

Choi

2015

Diabetes Metab J

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Non-alcoholic fatty liver disease, which is considered a hepatic manifestation of metabolic syndrome, independently increases the risks of developing cardiovascular disease (CVD) and type 2 diabetes mellitus. Recent emerging evidence suggests that a group of predominantly liver-derived proteins called hepatokines directly affect the progression of atherosclerosis by modulating endothelial dysfunction and infiltration of inflammatory cells into vessel walls. Here, we summarize the role of the representative hepatokines fibroblast growth factor 21, fetuin-A, and selenoprotein P in the progression of CVD.

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Section: Fetuin-asupporting

confidence: 76%

Hepatokines as a Link between Obesity and Cardiovascular Diseases

Yoo

Choi

2015

Diabetes Metab J

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“…Previously, we showed a significant decrease in circulating fetuin-A level, which was the first hepatokine discovered, after 12 weeks of caloric restriction. This decrease in fetuin-A was accompanied by improvements in visceral fat area, blood pressure, lipid profiles, and glucose levels [19]. These results suggest that the changes in circulating hepatokines might be associated with the beneficial effects of caloric restriction.…”

Section: Discussionmentioning

confidence: 99%

Association of leukocyte cell-derived chemotaxin 2 (LECT2) with NAFLD, metabolic syndrome, and atherosclerosis

et al. 2017

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ObjectivePrevious studies have shown that leukocyte cell-derived chemotaxin 2 (LECT2), a recently discovered hepatokine, is associated with the inflammatory response and insulin resistance. We examined circulating plasma LECT2 levels in the subjects with non-alcoholic fatty liver disease (NAFLD) or metabolic syndrome.MethodsWe analyzed plasma LECT2 levels from the subjects of age- and sex-matched 320 adults with or without NAFLD who completed a health check-up at the Health Promotion Center of Korea University Guro Hospital.ResultsIndividuals with NAFLD showed significantly higher LECT2 levels (31.2 [20.9, 41.5] vs. 24.5[16.3, 32.7] ng/ml, P <0.001) as well as components of MetS compared to those without NAFLD. Furthermore, circulating LECT2 concentrations were greater in subjects with MetS (32.6 [17.8, 45.0] vs. 27.0 [18.7, 33.7] ng/ml, P = 0.016) and were associated with anthropometric measures of obesity, lipid profiles, high sensitivity C-reactive protein (hsCRP) and liver aminotransferase levels. However, there was no significant relationship between LECT2 levels and indicators of subclinical atherosclerosis, such as carotid intima-media thickness (CIMT) and brachial ankle pulse wave velocity (baPWV). Multivariate analysis demonstrated a progressively increasing trend of odds ratios for NAFLD according to quartiles of LECT2 levels after adjusting for risk factors, although the relationship was attenuated after further adjustment for waist circumference and lipid levels.ConclusionCirculating LECT2 concentrations were increased in individuals with NAFLD and those with MetS, but not in those with atherosclerosis. The relationship between LECT2 and both NAFLD and MetS might be mediated by its association with abdominal obesity and lipid metabolism.Trial registrationClinicaltrials.gov NCT01594710

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“…In humans, numerous studies have shown that higher fetuin-A levels are predictive of type 2 DM [4–7]. Furthermore, one recent study found that fetuin-A levels decreased significantly following 12 weeks of caloric restriction in overweight women with type 2 DM [8]. …”

Section: Introductionmentioning

confidence: 99%

Circulating fetuin-A levels are not affected by short and long-term energy deprivation and/or by leptin administration

et al. 2014

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Objective Fetuin-A may mediate cross-talk between the liver and adipose tissue. We studied the physiologic regulation of fetuin-A and explored its potential regulation by leptin. Design and Methods Fetuin-A levels were measured in three interventional studies as well as in in vitro experiments. Study 1: 15 lean subjects received placebo or physiologic replacement-dose recombinant human leptin (metreleptin) following short term complete caloric deprivation to induce severe hypoleptinemia; Study 2: 7 women with relative leptin deficiency due to strenuous exercise or low weight received 3 months of metreleptin; Study 3: 17 women with relative leptin deficiency were randomized to receive metreleptin or placebo over 9 months. In study 4 human hepatoma Hep G2 cells were treated with leptin. Fetuin-A mRNA expression and secretion were measured. Results Complete caloric deprivation significantly decreased leptin but had no effect on fetuin-A levels. Normalizing leptin levels with metreleptin in hypoleptinemic subjects had no effect on circulating fetuin-A levels. Leptin treatment had no effect on fetuin-A mRNA expression and secretion in vitro. Conclusions Circulating fetuin-A levels are not affected by short and long-term energy deprivation. Furthermore, both in vivo and in vitro experiments confirm that fetuin-A is not regulated by leptin.

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The effects of caloric restriction on Fetuin‐A and cardiovascular risk factors in rats and humans: a randomized controlled trial

Abstract: Caloric restriction significantly reduced the hepatic expression of fetuin-A and its circulating levels and improved several cardiovascular risk factors in obese rats and humans with type 2 diabetes.

Cited by 57 publications

References 30 publications

Hepatokines as a Link between Obesity and Cardiovascular Diseases

Hepatokines as a Link between Obesity and Cardiovascular Diseases

Association of leukocyte cell-derived chemotaxin 2 (LECT2) with NAFLD, metabolic syndrome, and atherosclerosis

Circulating fetuin-A levels are not affected by short and long-term energy deprivation and/or by leptin administration

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