The effects of aqueous extracts prepared from the leaves of Pistacia lentiscus in experimental liver disease

Ljubuncic, Predrag; Song, Hui; Cogan, Uri; Azaizeh, Hassan; Bomzon, Arieh

doi:10.1016/j.jep.2005.03.006

Cited by 68 publications

(49 citation statements)

References 15 publications

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“…Chios mastic has been previously shown to exert various biological properties in vitro [12] , in experimental animal models [18] and in humans [14] . In the current study, we demonstrated that mastic was effective in the regulation of inflammation, evaluated by CRP, IL-6, TNF-α and MCP-1 in plasma, as well as in the regulation of oxidative stress, evaluated by TAP.…”

Section: Discussionmentioning

confidence: 99%

“…With reference to gastrointestinal disorders, the effectiveness of the resin against peptic ulcers is evident [14] in most studies, while only in two reports there is no effect on H pylori eradication in vivo [15,16] . Furthermore, regarding gastric mucosa, the plant has been shown to be hepatoprotective in tetrachloride-intoxicated rats [17] and to suppress the extent of iron-induced lipid peroxidation in rat liver homogenates [18] , without any toxic effect. A major constituent of mastic, namely oleanolic acid, is among the best-known triterpenes with biological properties against chemically induced liver injury in laboratory animals, exerting anti-inflammatory and antitumor-promotion effects [19] .…”

Section: Introductionmentioning

confidence: 99%

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Chios mastic treatment of patients with active Crohn’s disease

Kaliora

Stathopoulou²,

Triantafillidis³

et al. 2007

WJG

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AIM:To evaluate the effectiveness of mastic administration on the clinical course and plasma inflammatory mediators of patients with active Crohn's disease (CD). METHODS:This pilot study was conducted in patients with established mild to moderately active CD, attending the outpatient clinics of the hospital, and in healthy controls. Ten patients and 8 controls were recruited for a 4-wk treatment with mastic caps (6 caps/d, 0.37 g/cap). All patients successfully completed the protocol. CD Activity Index (CDAI), Nutritional Risk Index (NRI), C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemotactic protein-1 (MCP-1), and total antioxidant potential (TAP) were evaluated in the plasma at baseline and at the end of the treatment period. Results were expressed as mean values ± SE and P < 0.05 was considered to indicate statistical significance. RESULTS:Patients exhibited significant reduction of CDAI (222.9 ± 18.7 vs 136.3 ± 12.3, P = 0.05) as compared to pretreament values. Plasma IL-6 was significantly decreased (21.2 ± 9.3 pg/mL vs 7.2 ± 2.8 pg/ mL, P = 0.027), and so did CRP (40.3 ± 13.1 mg/mL vs 19.7 ± 5.5, P = 0.028). TAP was significantly increased (0.15 ± 0.09 vs 0.57 ± 0.15 mmol/L uric acid, P = 0.036). No patient or control exhibited any kind of side effects. CONCLUSION:The results suggest that mastic significantly decreased the activity index and the plasma levels of IL-6 and CRP in patients with mildly to moderately active CD. Further double-blind, placebo-controlled studies in a larger number of patients are required to clarify the role of this natural product in the treatment of patients with CD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chios mastic treatment of patients with active Crohn’s disease

Kaliora

Stathopoulou²,

Triantafillidis³

et al. 2007

WJG

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“…The extractions were carried from the aerial part plants by methanol and distilled water according to the method of [7][8] .…”

Section: Methods 221 Preparation Of Extractmentioning

confidence: 99%

Free radicals scavenging activity and reducing power of two Algerian Sahara medicinal plants extracts

Benslama¹,

Harrar²

2016

Int. J. Herb. Med.

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The aim of this study is to evaluate antioxidant activity of aqueous (Aq.E) and methanolic (Met.E) extracts of Zygophyllum album L. (Zygophyllaceae) and Arthrophytum scoparium (Chenpodiacea), two medicinal plant from Algerian Sahara used in traditional pharmacopoeia. The results showed that Aq.E have the heights yields 24% and 22.3% for Z. album and A. scoparium respectively. Qualitative analysis of showed that the Met.E of Z. album of had the highest amount of polyphenols (202.26±4.73 µg GAE/mg E) and flavonoids (15.77±0.94 µg QE/mg E). The antioxidant activity of extracts was evaluated by 2, 2'-diphenyl-1-picrylhydrazyl (DPPH) and reducing power assay. Results showed that the extracts of A. scoparium. Have the highest free radical scavenger activity in DPPH test (EC50=0.096±0.001 and 0.108±0.002 mg/ml for Met.E and Aq.E respectively). In addition, the results of reducing power assay demonstrated that Met.E of Z. album had the highest effect with 2399.65±12.31 µg ascorbic acid equivalent/mg E.Our results showed that the methanolic extract reported a considerable free radicals scavenging activity and reducing effect, may be due to their richness on polyphenols and flavonoids.

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“…This was carried out as previous demonstrated, with slight modifications, by Predrag et al (2005). The freshly collected stem bark was cut into pieces and shade dried at room temperature for 10 days and milled using an electric blender.…”

Section: Preparation Of Croton Macrostachyus Stem Bark Extractsmentioning

confidence: 99%