The effects of antibiotic-supplemented bone allografts on contaminated, partially avulsive fractures of the canine ulna

Local antibiotic delivery with demineralized bone matrix

“…In 1984, Petri mixed antibiotic infused demineralized allograft with gelatin and implanted into a canine ulna (Petri and Schaberg 1984). All fractures treated by the standard of care method developed acute osteomyelitis and nonunion, whereas the antibiotic treatment group resulted in bone union without infection.…”

Local antibiotic delivery with demineralized bone matrix

“…In 1984, Petri mixed antibiotic infused demineralized allograft with gelatin and implanted into a canine ulna (Petri and Schaberg 1984). All fractures treated by the standard of care method developed acute osteomyelitis and nonunion, whereas the antibiotic treatment group resulted in bone union without infection.…”

Examination of the Quality of Particulate and Filtered Mandibular Bone Chips for Oral Implants: An In Vitro Study

“…The cytotoxic or cytostatic effect of Clindamycin on primary human osteoblasts observed by Duewelhenke and coworkers might be reduced by choosing an alternative antibiotic, e.g., Ciprofloxacin. Beyond this, using antibiotic-supplemented bone grafts or rinsing the bone chips with a solution of antibiotics must be considered carefully [27,28,55,56]. Isefuku and colleagues reported that high concentration of Gentamicin inhibited proliferation of osteoblast-like cells in vitro while Rifampicin was shown to be harmful on osteoblasts and bone tissue [57,58].…”

Local Antibiotic Delivery with Bovine Cancellous Chips

“…There have been several attempts to supplement allografts with antibiotics [42–46]. In an effort to achieve a more sustained release of antibiotics, demineralized allograft mixed with antibiotic powders and gelatin was used to reduce infection in a dog model [47]. The results of the treatment with antibiotic-supplemented bone were compared to the standard of care.…”

Local antibiotic delivery with demineralized bone matrix

“…In 1984, Petri mixed antibiotic infused demineralized allograft with gelatin and implanted into a canine ulna (Petri and Schaberg 1984). All fractures treated by the standard of care method developed acute osteomyelitis and nonunion, whereas the antibiotic treatment group resulted in bone union without infection.…”

Examination of the Quality of Particulate and Filtered Mandibular Bone Chips for Oral Implants: An In Vitro Study

“…The cytotoxic or cytostatic effect of Clindamycin on primary human osteoblasts observed by Duewelhenke and coworkers might be reduced by choosing an alternative antibiotic, e.g., Ciprofloxacin. Beyond this, using antibiotic-supplemented bone grafts or rinsing the bone chips with a solution of antibiotics must be considered carefully [27,28,55,56]. Isefuku and colleagues reported that high concentration of Gentamicin inhibited proliferation of osteoblast-like cells in vitro while Rifampicin was shown to be harmful on osteoblasts and bone tissue [57,58].…”

Local Antibiotic Delivery with Bovine Cancellous Chips

“…There have been several attempts to supplement allografts with antibiotics [42–46]. In an effort to achieve a more sustained release of antibiotics, demineralized allograft mixed with antibiotic powders and gelatin was used to reduce infection in a dog model [47]. The results of the treatment with antibiotic-supplemented bone were compared to the standard of care.…”

Local antibiotic delivery with demineralized bone matrix

“…In 1984, Petri mixed antibiotic infused demineralized allograft with gelatin and implanted into a canine ulna (Petri and Schaberg 1984). All fractures treated by the standard of care method developed acute osteomyelitis and nonunion, whereas the antibiotic treatment group resulted in bone union without infection.…”

Examination of the Quality of Particulate and Filtered Mandibular Bone Chips for Oral Implants: An In Vitro Study

“…The cytotoxic or cytostatic effect of Clindamycin on primary human osteoblasts observed by Duewelhenke and coworkers might be reduced by choosing an alternative antibiotic, e.g., Ciprofloxacin. Beyond this, using antibiotic-supplemented bone grafts or rinsing the bone chips with a solution of antibiotics must be considered carefully [27,28,55,56]. Isefuku and colleagues reported that high concentration of Gentamicin inhibited proliferation of osteoblast-like cells in vitro while Rifampicin was shown to be harmful on osteoblasts and bone tissue [57,58].…”

Local Antibiotic Delivery with Bovine Cancellous Chips

“…There have been several attempts to supplement allografts with antibiotics [42–46]. In an effort to achieve a more sustained release of antibiotics, demineralized allograft mixed with antibiotic powders and gelatin was used to reduce infection in a dog model [47]. The results of the treatment with antibiotic-supplemented bone were compared to the standard of care.…”