The Effects of an Adhesive in the Middle Ear

The effects of fibrin tissue adhesive on the middle ear

“…No reaction was found at a later stage, or at any stage in the cochlea. This is in sharp contrast to the inflammatory reaction in the labyrinth found in a third of the cases after the application of enbucrilate (Histoacryl) in the middle ear of rabbits which indicates a toxic effect of enbucrylate on the inner ear (Heumann and Steinbach, 1980). Bone erosion was not found at the site of application of the glue in any of the ears, in contrast to the advanced erosion of bone found by Heumann and Steinbach Figs.…”

Traumatic dislocation of the incudostapedial joint repaired with fibrin tissue adhesive

“…The clot constituted by the fibrin glue is a physiologic component found in tissue repair, and this makes it different from other types of glue such as the cyanoacrylates, which bear high fibrin formation, and is very difficult to use in moist tissue, induce fibrosis, foreign body reaction, and significant inflammatory response 15, 16. Moreover, the polymerization of this family of tissue glue is exothermic and it should be avoided in areas that may be liable to heat damage.…”

“…Moreover, the polymerization of this family of tissue glue is exothermic and it should be avoided in areas that may be liable to heat damage. Thus, they are not recommended for middle ear surgery 15, 16…”

A traumatic ossicular disruption successfully repaired with n-butyl cyanoacrylate tissue adhesive

“…1 More recent compounds have been shown to be neither ototoxic 2 nor to cause signi cant in ammatory response, 3 although some controversy surrounds these assertions as contemporary studies 4 have demonstrated signi cant tissue reaction. It may be that the differences between these and other studies can be explained by the different species of animal utilized.…”

“…Cyanoacrylate-derived adhesives have been used for nearly 40 years in many branches of surgery; however, early enthusiasm for their use in middle-ear surgery was tempered by the in ammatory reaction observed and the ototoxic nature of the early adhesives. 1 More recent compounds have been shown to be neither ototoxic 2 nor to cause signi cant in ammatory response, 3 although some controversy surrounds these assertions as contemporary studies 4 have demonstrated signi cant tissue reaction. It may be that the differences between these and other studies can be explained by the different species of animal utilized.…”