The effects of allium sativum on immunity within the scope of COVID-19 infection

Donma, Mustafa Metın; Donma, Orkide

doi:10.1016/j.mehy.2020.109934

Cited by 115 publications

(84 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The trial showed that garlic can upregulate immune response genes and activate apoptosis and the xenobiotic metabolism in people who regularly consume garlic containing meals ( Charron et al, 2015 ). The anti-inflammatory and immunomodulatory potential of garlic was also subject to a most recent publication indicating that garlic may be beneficial as a preventive measure in the current COVID-19 pandemic ( Donma & Donma, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data

Rouf

Uddin

Sarker

et al. 2020

Trends in Food Science & Technology

195

140

View full text Add to dashboard Cite

Background Garlic ( Allium sativum L.) is a common herb consumed worldwide as functional food and traditional remedy for the prevention of infectious diseases since ancient time. Garlic and its active organosulfur compounds (OSCs) have been reported to alleviate a number of viral infections in pre-clinical and clinical investigations. However, so far no systematic review on its antiviral effects and the underlying molecular mechanisms exists. Scope and approach The aim of this review is to systematically summarize pre-clinical and clinical investigations on antiviral effects of garlic and its OSCs as well as to further analyse recent findings on the mechanisms that underpin these antiviral actions. PubMed, Cochrane library, Google Scholar and Science Direct databases were searched and articles up to June 2020 were included in this review. Key findings and conclusions Pre-clinical data demonstrated that garlic and its OSCs have potential antiviral activity against different human, animal and plant pathogenic viruses through blocking viral entry into host cells, inhibiting viral RNA polymerase, reverse transcriptase, DNA synthesis and immediate-early gene 1(IEG1) transcription, as well as through downregulating the extracellular-signal-regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signaling pathway. The alleviation of viral infection was also shown to link with immunomodulatory effects of garlic and its OSCs. Clinical studies further demonstrated a prophylactic effect of garlic in the prevention of widespread viral infections in humans through enhancing the immune response. This review highlights that garlic possesses significant antiviral activity and can be used prophylactically in the prevention of viral infections.

show abstract

Section: Resultsmentioning

confidence: 99%

Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data

Rouf

Uddin

Sarker

et al. 2020

Trends in Food Science & Technology

195

140

View full text Add to dashboard Cite

show abstract

“…4,[127][128][129][130][131][132][133][134][135] These include Withania somnifera (Indian ginseng, Ashwagandha), [136][137][138] Curcuma longa (curcuma/turmeric), 130,138 Allium sativum (garlic), 132 Camellia sinensis (green tea), 139 Glycyrrhiza glabra (licorice), 130,133,140 Tinospora cordifolia (guduchi), 141 and others. 4,131,135 Some of the active constituents include phenolics, 139 flavonoids, 142 alkaloids, 143 saponins and steroids 144 and many more. 135 Glycyrrhizin, 145 glycyrrhizic acid, 130 catechin and curcumin 146 are some of the important active principles in few medicinal plants (Licorice, turmeric) believed to be effective against SARS-CoV-2.…”

Section: Immune Modulatorsmentioning

confidence: 99%

Immunotherapies and immunomodulatory approaches in clinical trials - a mini review

Yatoo

Hamid

Rather

et al. 2021

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

The coronavirus disease (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created havoc worldwide. Due to the non-availability of any vaccine or drugs against COVID-19, immunotherapies involving convalescent plasma, immunoglobulins, antibodies (monoclonal or polyclonal), and the use of immunomodulatory agents to enhance immunity are valuable alternative options. Cell-based therapies including natural killer cells, T cells, stem cells along with cytokines and toll-like receptors (TLRs) based therapies are also being exploited potentially against COVID-19. Future research need to strengthen the field of developing effective immunotherapeutics and immunomodulators with a thrust of providing appropriate, affordable, convenient, and cost-effective prophylactic and treatment regimens to combat global COVID-19 crisis that has led to a state of medical emergency enforcing entire countries of the world to devote their research infrastructure and manpower in tackling this pandemic.

show abstract

“…In einer neueren Studie aus 2016 mit einem "Aged Garlic"-Extrakt konnte an 120 Teilnehmern (ebenfalls über 3 Monate) keine Reduzierung der Inzidenz von Infekten beobachtet werden, allerdings wurden in der Interventionsgruppe deutlich weniger Symptome berichtet und auch hier war die Dauer der Erkrankung im Schnitt geringer [21]. Vorgeschlagen werden hinsichtlich Covid-19 günstige Wirkungen auf das Immunsystem [6]. Die Große Kapuzinerkresse (T. majus L.) ist erst in den 1680er-Jahren in Europa greifbar, erstmals 1687 beschrieben von Paul Hermann, Professor für Botanik in Leiden.…”

Section: Knoblauch Und Zwiebelnunclassified

„Sämmtlich sind sie aber beissend und blähend…“

Niedenthal¹

2020

Zeitschrift für Phytotherapie

View full text Add to dashboard Cite

show abstract

The effects of allium sativum on immunity within the scope of COVID-19 infection

Cited by 115 publications

References 30 publications

Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data

Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data

Immunotherapies and immunomodulatory approaches in clinical trials - a mini review

„Sämmtlich sind sie aber beissend und blähend…“

Contact Info

Product

Resources

About