The effectiveness of vitamin C for patients with severe viral pneumonia in respiratory failure

Lee, Song-I; Lim, Chae‐Man; Koh, Younsuck; Huh, Jae-Wan; Lee, Jae Seung; Hong, Sang‐Bum

doi:10.21037/jtd-20-1306

Cited by 6 publications

(7 citation statements)

References 42 publications

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“…In addition, T cell migration, and thymus and activation-regulated chemokine (TARC) production were reduced. Therefore, the results showed the potential effect of aptamin (a modified form of vitamin C that consists aptamers, DNA fragments) on inflammatory lesions such as atopic dermatitis (AD) (D. Lee et al 2021a , b ).…”

Section: Resultsmentioning

confidence: 99%

“…Treatment of pneumonia patients (35 cases) with a single-dose vitamin C for 28 days indicated that there was no association between the vitamin C treatment alone and prognosis and mortality improvement in individuals with respiratory failure and severe viral pneumonia (Lee et al 2021a , b ). The preventive effect of vitamin C has been studied in patients with COVID-19 and pneumonia.…”

Section: Main Textmentioning

confidence: 99%

“… Improved the symptoms of allergic rhinitis Munjal ( 2020 ) 2000 mg/day, 8 weeks Decreased nasal congestion, sneezing, nasal itching, runny nose, NBF and MDA levels Tongtako et al ( 2018 ) 2 g, 2 days Increased PC15FEV1 Bucca et al ( 1990 ) 7.5 g/50 mL Decreased allergy-related symptoms Vollbracht et al ( 2018 ) Im. D Exp HaCaT human keratinocyte cell line – Gavage Decreased T cell migration and TARC production Lee et al ( 2021a , b ) LPS in guinea pigs 0, 25, or 250 mg Reduced mRNA levels of cytokines Fraser et al ( 1980 ) Guinea pigs 4 g/kg for 14 days Improved T lymphocyte function in cell-mediated cytotoxicity Anthony et al ( 1979 ) Mouse model 5 mg/day Increased levels of TNF-α and IFN-γ and decreased level of IL-4 Noh et al ( 2005 ) Mice model 10 μg/mL Up-regulated IL-17 through Jmjd2 histone demethylase enzymes Song et al ( 2017 ) …”

Section: Main Textmentioning

confidence: 99%

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The effects of vitamin C on respiratory, allergic and immunological diseases: an experimental and clinical-based review

et al. 2023

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Vitamin C is used in modern medicine supplements for treatment of various disorders associated with oxidative stress, inflammation and immune dysregulation. In this review article, experimental and clinical results regarding the effects of vitamin C on respiratory immunologic, and allergic diseases are reviewed. Various databases and appropriate keywords are used to search the effect of vitamin C on respiratory diseases until the end of May 2022. Books, theses and articles were included. These studies assessed the effects of vitamin C on respiratory disorders including asthma, chronic obstructive pulmonary disease (COPD), lung infection and lung cancer. Vitamin C showed relaxant effect on tracheal smooth muscle via various mechanisms. The preventive effects of vitamin C were mediated by antioxidant, immunomodulatory and anti-inflammatory mechanisms in the experimental animal models of different respiratory diseases. Some clinical studies also indicated the effect of vitamin C on lung cancer and lung infections. Therefore, vitamin C could be used a preventive and/or relieving therapy in respiratory diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Main Textmentioning

confidence: 99%

Section: Main Textmentioning

confidence: 99%

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The effects of vitamin C on respiratory, allergic and immunological diseases: an experimental and clinical-based review

et al. 2023

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“…In contrast, a study conducted on a group of patients with severe viral pneumonia with respiratory failure did not show a reduction in their mortality from receiving VC as compared to a control group [ 148 ]. In contrast, the evaluation of the effect of VC on the treatment of patients with herpes zoster has shown a reduction in the incidence of postherpetic neuralgia, as the antioxidant activity may play an essential role in reducing the pain caused by herpes zoster [ 149 ].…”

Section: Vitamin Cmentioning

confidence: 99%

The Variable Nature of Vitamin C—Does It Help When Dealing with Coronavirus?

et al. 2022

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still spreading worldwide. For this reason, new treatment methods are constantly being researched. Consequently, new and already-known preparations are being investigated to potentially reduce the severe course of coronavirus disease 2019 (COVID-19). SARS-CoV-2 infection induces the production of pro-inflammatory cytokines and acute serum biomarkers in the host organism. In addition to antiviral drugs, there are other substances being used in the treatment of COVID-19, e.g., those with antioxidant properties, such as vitamin C (VC). Exciting aspects of the use of VC in antiviral therapy are its antioxidant and pro-oxidative abilities. In this review, we summarized both the positive effects of using VC in treating infections caused by SARS-CoV-2 in the light of the available research. We have tried to answer the question as to whether the use of high doses of VC brings the expected benefits in the treatment of COVID-19 and whether such treatment is the correct therapeutic choice. Each case requires individual assessment to determine whether the positives outweigh the negatives, especially in the light of populational studies concerning the genetic differentiation of genes encoding the solute carriers responsible forVC adsorption. Few data are available on the influence of VC on the course of SARS-CoV-2 infection. Deducing from already-published data, high-dose intravenous vitamin C (HDIVC) does not significantly lower the mortality or length of hospitalization. However, some data prove, among other things, its impact on the serum levels of inflammatory markers. Finally, the non-positive effect of VC administration is mainly neutral, but the negative effect is that it can result in urinary stones or nephropathies.

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“…Scurvy has been frequently correlated with increased susceptibility to infections, predominantly of the respiratory tract, pneumonia, and pulmonary tuberculosis, and remains the primary cause of death. [30][31][32] A classic example is the consumption of vitamin C, which plays a prophylactic role due to its ability to facilitate the favorable immune response required for the growth and repair of body tissues. 33 It also reduces the susceptibility of the lower respiratory tract to infections.…”

Section: Introductionmentioning

confidence: 99%

Fat-Soluble Vitamins and the Current Global Pandemic of COVID-19: Evidence-Based Efficacy from Literature Review

Samad¹,

Dutta²,

Sodunke³

et al. 2021

JIR

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The outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), later named COVID-19 by the World Health Organization (WHO), was initiated at Wuhan, Hubei, China, and there was a rapid spread of novel SARS-CoV-2 and the disease COVID-19 in late 2019. The entire world is now experiencing the challenge of COVID-19 infection. However, still very few evidence-based treatment options are available for the prevention and treatment of COVID-19 disease. The present review aims to summarize the publicly available information to give a comprehensive yet balanced scientific overview of all the fat-soluble vitamins concerning their role in SARS-CoV-2 virus infection. The roles of different fat-soluble vitamins and micronutrients in combating SARS-CoV-2 infection have been recently explored in several studies. There are various hypotheses to suggest their use to minimize the severity of COVID-19 infection. These vitamins are pivotal in the maintenance and modulation of innate and cell-mediated, and antibody-mediated immune responses. The data reported in recent literature demonstrate that deficiency in one or more of these vitamins compromises the patients' immune response and makes them more vulnerable to viral infections and perhaps worse disease prognosis. Vitamins A, D, E, and K boost the body's defense mechanism against COVID-19 infection and specifically prevent its complications such as cytokine storm and other inflammatory processes, leading to increased morbidity and mortality overemphasis. However, more detailed randomized double-blind clinical pieces of evidence are required to define the use of these supplements in preventing or reducing the severity of the COVID-19 infection.

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The effectiveness of vitamin C for patients with severe viral pneumonia in respiratory failure

Cited by 6 publications

References 42 publications

The effects of vitamin C on respiratory, allergic and immunological diseases: an experimental and clinical-based review

The effects of vitamin C on respiratory, allergic and immunological diseases: an experimental and clinical-based review

The Variable Nature of Vitamin C—Does It Help When Dealing with Coronavirus?

Fat-Soluble Vitamins and the Current Global Pandemic of COVID-19: Evidence-Based Efficacy from Literature Review

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