The effect of whole-body X-irradiation of guinea pigs on liver ribonucleic acid synthesis

Hidvégi, Egon J.; Bölöni, Erzsébet; Holland, John J.; Antoni, Ferenc András; Varteresz, V.

doi:10.1042/bj1160503

Cited by 23 publications

(3 citation statements)

References 36 publications

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“…RER showed early reversal of these tnorphologic changes, and free ribosomes, the predominant form of cytoplasmic RNA in the basal cells, rctnained essentially unaltered. Although free ribosomes have been reported decreased iti some studies (Quastler & Hampton 1962, Hampton 1966) and increased in others (Hidvegi et al 1968, 1970, Unger & Hidvegi 1971, their apparent changes in concentration in our tnaterial merely seemed to reflect the changes in cytoplasmic volume. It is possible that similar fluctuations in cell volume contributed to the variable findings in other tissues.…”

Section: Cotnparison With Other Tissuesmentioning

confidence: 50%

An ultrastructural study of the effects of x‐irradiation on the oral epithelium of the rat: Qualitative aspects

Liu

Meyer

Waterhouse

1976

J Oral Pathology Medicine

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Adult male rats of Simonsen strain were given a dose of 5000 r at 50 peak KV of x-irradiation directed at the lower lip, which was everted through a hole in a lead rubber cylinder shielding the head and body of the animal. Light and electron microscopic observations were made on specimens of lip oral mueosa from animals killed at 2, 6, 26 and 50 h and at 12 days after irradiation. The experimental model met the aim of permitting the study of the sequential effects of a high dose of irradiation without causing ulceration of the mueosa.Widespread degenerative changes were noted in the basal cells as early as 2 h after x-irradiation, increasing in degree up to 50 h. They included inflation of the outer nuclear envelope and rough endoplasmie retieulum (RER) with loss of ribosomes, swelling of mitoehondria and disarrangement of cristae evident at 2 h, followed at 6 h by swelling of nucleus and cytoplasm and 26 h by frank membrane breaks. Irreversible degrees of damage were noted in a small though growing minority of cells. Immediate mobilization of the Golgi-lysosomal system was evident as an increase in size of the zone, maximal at 2 h, and subsequent autophagic activity. Signs of recovery, beginning at 26 h, were noted in nuclear envelope, RER, intercellular space, and in mitotie activity by 50 h. Virtually complete recovery was seen at 12 days.It is held that the successful eonfinement of irradiation to a small tissue volume, the effective activity of the lysosomal system and the short epithelial turnover time were important factors in limiting the damage and in permitting recovery.

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Section: Cotnparison With Other Tissuesmentioning

confidence: 50%

An ultrastructural study of the effects of x‐irradiation on the oral epithelium of the rat: Qualitative aspects

Liu

Meyer

Waterhouse

1976

J Oral Pathology Medicine

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“…This increase of oxidative metabolism following X-irradiation may be the result of increased enzyme synthesis and/or of decreased degradation of the enzyme. Several reports of stimulation of hepatic R N A (1,9,17,22)-and protein (1,4, 9,2I)synthesis suggest that an increased enzyme formation may be implicated.…”

Section: Discussionmentioning

confidence: 99%

Induction by Phenobarbital of Aniline‐p‐hydroxylase in Mouse Liver under the Influence of X‐Irradiation and 2,4,6‐Triethyleneimino‐1,3,5‐triazine

Erber

Hollatz

Tempel

1977

Zentralblatt für Veterinärmedizin Reihe A

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Summary The phenobarbital‐induced activity of aniline‐p‐hydroxylase in livers of mice was enhanced additionally when the animals were X‐irradiated 4–16 hours before the administration of the inducer. The same effect could be demonstrated after repeated irradiation with low doses. 2,4,6‐triethyleneimino‐1,3,5‐triazine (tretamine) inhibited the induction of aniline‐p‐hydroxylase only when administered in extremely high doses. Lower doses resulted in “superinduction”. Zusammenfassung Zur Wirkung von Röntgenbestrahlung und 2,4,6‐Triäthylenimino‐1,3,5‐triazin auf die Induktion der Anilin‐p‐hydroxylase der Mäuseleber Die durch Phenobarbital induzierte Aktivität der Anilin‐p‐hydroxylase der Mäuseleber wurde durch Röntgenbestrahlung der Tiere 4–16 Stunden vor Applikation des Barbiturats zusätzlich erhöht. Auch die mehrmalige Behandlung mit kleinen Strahlendosen bewirkte einen Aktivitätsanstieg. Das Zytostatikum 2,4,6‐Triäthylenimino‐1,3,5‐triazin hemmte nur in extrem hoher Dosierung die Induktion der Anilin‐p‐hydroxylase, während niedrigere Dosen zu „Superinduktion” führten. Résumé Action d'une radiation et de la 2,4,6‐triéthylèneimino‐1,3,5‐triazine sur l'induction de l'aniline‐p‐hydroxylase du foie de souris L'activité de l'aniline‐p‐hydroxylase du foie de souris induite par du phénobarbital a été augmentée par une radiation aux rayons x des animaux 4–16 heures avant l'application du barbiturate. Une application en plusieurs temps de petites doses de radiation a également provoqué une augmentation de l'activiteé. Le cytostatique 2,4,6‐triéthylèneimino‐1,2,5‐triazine n'a inhibé l'induction de l'aniline‐p‐hydroxylase qu'à des doses extrêmement élevées, alors que des doses plus faibles oit provoqué une »superinduction«. Resumen Inducción de anilina‐p‐hidroxilasa por fenobarbital en el hígado de ratón bajo el influjo de la irradiación X y de la 2,4,6‐trietileneimino‐1,3,5‐triazina La actividad inducida por fenobarbital de la anilina‐p‐hidroxilasa en hígados de ratones fué aumentada adicionalmente cuando los animales habían sido irradiados con rayos × 4–16 horas antes de administrar el inductor. El mismo efecto se pudo demostrar después de irradiaciones repetidas con dosis menores. 2,4,6‐trietileneimino‐1,3,5‐triazina (tretamina) inhibía solo la induccíon de anilina‐p‐hidroxilasa cuando era administrada en dosis elevadas. Dosis menores redundaban en un «superinducción».

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“…It has been established that liver rRNA synthesis is enhanced after whole-body X-irradiation of animals (Hidvegi et al, 1965(Hidvegi et al, , 1966a(Hidvegi et al, , 1970Cammarano etal., 1969;Popov etal., 1971) and RNA polymerase activity is also increased (Omata et al, 1968;Hidv6gi et al, 1970;Yatvin, 1970). These were followed by a rise in the rRNA and mRNA contents (Hidvegi et al, 1970).…”

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confidence: 95%

Increased synthesis of low-molecular-weight nuclear ribonucleic acids of rat liver after γ irradiation and hepatectomy

Fónagy

Hidvégi

1975

Biochemical Journal

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Incorporation of [3H]orotic acid into low-molecular-weight nRNA of rat liver, fractionated on polyacrylamide gels, increased 6-12h after partial hepatectomy and 6h after gamma-irridation at 2000 R. The incorporation of orotic acid was particularly increased into the 4.5S, 5S and approx. 10S nRNA fractions. If the irradiation was given after 6h of regeneration and RNA was isolated from the nucleus 12h after hepatectomy then the incorporation of orotic acid into these low-molecular-weight nRNA components was greater than after hepatectomy or irradiation alone.

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The effect of whole-body X-irradiation of guinea pigs on liver ribonucleic acid synthesis

Cited by 23 publications

References 36 publications

An ultrastructural study of the effects of x‐irradiation on the oral epithelium of the rat: Qualitative aspects

An ultrastructural study of the effects of x‐irradiation on the oral epithelium of the rat: Qualitative aspects

Induction by Phenobarbital of Aniline‐p‐hydroxylase in Mouse Liver under the Influence of X‐Irradiation and 2,4,6‐Triethyleneimino‐1,3,5‐triazine

Increased synthesis of low-molecular-weight nuclear ribonucleic acids of rat liver after γ irradiation and hepatectomy

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