The effect of vanillic acid on ligature-induced periodontal disease in Wistar rats

Karataş, Özkan; Yüce, Hatice Balcı; Taşkan, Mehmet Murat; Gevrek, Fıkret; Yarkaç, Fatma Uçan; Keskin, Aslı; Karataş, Şükrüye Firuze Ocak; Toker, Hülya

doi:10.1016/j.archoralbio.2019.05.010

Cited by 20 publications

(18 citation statements)

References 38 publications

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“…In the present study, we have demonstrated that a high RUNX2 expression in MT‐treated rats is correlated to reduced bone loss. RUNX2 is associated with osteoblast differentiation, 38 bone synthesis, and mineralization 39 . Thus, it may be suggested that MT therapeutic effect seems to involve RUNX2 expression and osteoblast activation.…”

Section: Discussionmentioning

confidence: 99%

Leukotriene receptor antagonist reduces inflammation and alveolar bone loss in a rat model of experimental periodontitis

Moro

Oliveira

Santana

et al. 2021

Journal of Periodontology

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Background Leukotrienes (LTs) participate in the process of tissue damage in periodontal disease by leukocyte chemotaxis and osteoclastic activation. The activation of Cysteinyl‐LT receptor is associated with increased expression of proinflammatory molecules and osteoclastogenesis. However, its implications on periodontal disease progression have not been studied. The present study evaluated the effect of the cysteinyl‐LT receptor antagonist (montelukast [MT]) on ligature‐induced experimental periodontitis (EP) in rats. Methods Adult male Wistar rats were subjected to bilateral ligature‐induced periodontitis and orally treated with MT (at doses of 10 or 30 mg/kg/d, MT10, and MT30, respectively). Sham animals had the ligatures immediately removed and received placebo treatment. Sets of animals were euthanized 7, 14, or 21 days after ligature placement and the mandibles were removed for macroscopic evaluation of alveolar bone loss (ABL). In addition, histological analysis of periodontal tissues, myeloperoxidase (MPO) activity of gingival tissues, and periodontal tissue expression of collagen type I, RUNX2, RANK, RANKL, OPG, BLT1, Cys‐LTR1, LTA4H, and LTC4S were also analyzed. Results MT significantly reduced ABL at 14 (MT10 and MT30) and 21 days (MT10) (P < 0.05), gingival MPO at 7 (MT10) and 14 days (MT30) (P < 0.05), LTA4H, BLT1 and LTC4S gene expression on day 14 day (MT30, P < 0.05) and increased RUNX2 expression on day 14 (MT30, P < 0.05). Conclusion Systemic therapy with MT decreases periodontal inflammation and ABL in ligature‐induced periodontitis in rats.

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Section: Discussionmentioning

confidence: 99%

Leukotriene receptor antagonist reduces inflammation and alveolar bone loss in a rat model of experimental periodontitis

Moro

Oliveira

Santana

et al. 2021

Journal of Periodontology

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“…Periodontal destruction was induced using a procedure similar to that used in our previous studies 3,8,17,21 and other experimental rat studies 12,23 . The rats in the Ep and Ep‐Mel groups were anesthetized with xylazine hydrochloride (10 mg/bw) and ketamine hydrochloride (40 mg/bw); and the mandibular right and left first molar teeth were ligated with a 3.0‐silk suture.…”

Section: Methodsmentioning

confidence: 99%

“…Periodontal destruction was induced using a procedure similar to that used in our previous studies 3,8,17,21 and other experimental rat studies. 12,23 The rats in the Ep and Ep-Mel groups were anesthetized with xylazine hydrochloride * (10 mg/bw) and ketamine hydrochloride † (40 mg/bw); and the mandibular right and left first molar teeth were ligated with a 3.0-silk suture. The ligatures were retained in the submarginal position for 5 weeks to provoke the development of plaque accumulation, inflammatory alterations, and finally, periodontitis.…”

Section: Induction Of Periodontitismentioning

confidence: 99%

Melatonin ameliorates periodontitis‐related inflammatory stress at cardiac left ventricular tissues in rats

Köse

Bayrakdar

Akyıldız

et al. 2020

Journal of Periodontology

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Background: The aim of this experimental rat study was to investigate the potential inflammatory effects of periodontitis on cardiac left ventricular tissue and the therapeutic activity of melatonin on these effects. Methods: Twenty-four male Sprague-Dawley rats were randomly divided into three groups: control, experimental periodontitis (Ep), and Ep-melatonin (Ep-Mel). Experimental periodontitis was induced by placing and maintaining 3.0 silk ligatures at a peri marginal position on the left and right mandibular first molars for 5 weeks. Afterward, following the removal of ligatures, melatonin (10 mg/body weight) to Ep-Mel group, and vehicle (saline) to Ep and control groups were administered intraperitoneally for 14 days. On the first day of the eighth week, mandibular and cardiac left ventricular tissue samples were obtained following the euthanasia of the rats in all groups. Alveolar bone loss measurements were made on histological and microcomputed tomographic slices. Cardiac tissue levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), matrix metalloproteinase-9 (MMP-9), and cardiac Troponin-T (cTnT) were evaluated by appropriate biochemical methods. Results: Measurements made on the histological and microcomputed tomographic slices showed that melatonin significantly limits the ligature-induced periodontal tissue destruction (P <0.01). In addition, melatonin was detected to cause a significant decrease of MDA, MMP-9, and cTnT levels which were found to be significantly higher on rats with Ep (P <0.05) while having no significant effect on antioxidant levels (GSH, SOD, and CAT) (P >0.05). Conclusion: Melatonin might be regarded as an important supportive therapeutic agent to reduce the early degenerative changes and possible hypertrophic remodeling at cardiac left ventricular tissues provoked by periodontitis-related bacteria and/or periodontal inflammation.

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“…Noteworthily, we additionally detected gallic, gentisic, and syringic acid after basic hydrolysis, which was not reported by the authors of the cited study. Caffeic and vanillic acids have essential pharmacological effects in the treatment of depression [57] and periodontal diseases [58].…”

Section: Phytochemistrymentioning

confidence: 99%

Phenolic Constituents of Lamium album L. subsp. album Flowers: Anatomical, Histochemical, and Phytochemical Study

et al. 2020

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Flos Lamii albi has a high biological activity and is widely used in herbal medicine. The aim of the study was to characterize the secretory structures present in Lamium album subsp. album corolla and the location of phenolic compounds. Additionally, we carried out qualitative phytochemical analyses of flavonoids and phenolic acids. Light, fluorescence, and scanning electron microscopy were used to analyze the structure of the floral organs. The main classes of phenolic compounds and their localization were determined histochemically. Phytochemical analyses were performed with high-performance thin-layer chromatography (HPTLC) and high-performance liquid chromatography (HPLC). Six types of glandular trichomes were found which contained flavonoids, phenolic acids, and tannins. The phytochemical studies demonstrated the presence of caffeic, chlorogenic, ferulic, gallic, p-coumaric, protocatechuic, syringic, gentisic, and vanillic phenolic acids as well as rutoside, isoquercetin, and quercetin flavonoids. The corolla in L. album subsp. album has antioxidant properties due to the presence of various polyphenols, as shown by the histo- and phytochemical analyses. The distribution and morphology of trichomes and the content of phenolic compounds in the corolla have taxonomic, pharmacognostic, and practical importance, facilitating the identification of the raw material.

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The effect of vanillic acid on ligature-induced periodontal disease in Wistar rats

Cited by 20 publications

References 38 publications

Leukotriene receptor antagonist reduces inflammation and alveolar bone loss in a rat model of experimental periodontitis

Leukotriene receptor antagonist reduces inflammation and alveolar bone loss in a rat model of experimental periodontitis

Melatonin ameliorates periodontitis‐related inflammatory stress at cardiac left ventricular tissues in rats

Phenolic Constituents of Lamium album L. subsp. album Flowers: Anatomical, Histochemical, and Phytochemical Study

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