The Effect of Universal Leukodepletion of Packed Red Blood Cells on Postoperative Infections in High-Risk Patients Undergoing Abdominal Aortic Surgery

Baron, J. F.; Gourdin, Maximilien; Bertrand, Michèle; Mercadier, Anne; Delort, J; Kieffer, Édouard; Coriat, Pierre

doi:10.1097/00000539-200203000-00010

Cited by 50 publications

(58 citation statements)

References 46 publications

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“…In different studies, LR has been shown to have no effect on infection rates in colorectal surgery [32], elective orthopedic surgery [30], elective cardiac surgery [30,33], or elective major aortic surgery [25]. In-house mortality and LOS have also been shown to be equivalent in a general inpatient population receiving LR versus non-LR blood [34].…”

Section: Discussionmentioning

confidence: 99%

Leukoreduction Before Red Blood Cell Transfusion Has No Impact on Mortality in Trauma Patients

Phelan

Sperry

Friese

2007

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Leukoreduction Before Red Blood Cell Transfusion Has No Impact on Mortality in Trauma Patients

Phelan

Sperry

Friese

2007

Journal of Surgical Research

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“…No clear statement can be made whether universal leukoreduction was indeed associated with any clinical advantage with regard of overall mortality rate, infection rate, or cancer recurrence [74], [75], [76], [77], [78].…”

Section: Clinical Studies On Transfusion-related Immunomodulationmentioning

confidence: 99%

Transfusion-transmissible infections and transfusion-related immunomodulation

Buddeberg

Schimmer

Spahn

2008

Best Practice & Research Clinical Anaesthesiology

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Transfusion-transmissible infections and transfusion-related immunomodulation AbstractThe risk of acquiring a transfusion-transmitted infection has declined in recent years. However, after human immunodeficiency virus and hepatitis B and C virus transmission were successfully reduced, new pathogens are threatening the safety of the blood supply, especially in the face of rising numbers of immunocompromised transfusion recipients. Despite new standards in the manufacture and storage of blood products, bacterial contamination still remains a considerable cause of transfusion-related morbidity and mortality. Better allograft survival in kidney transplant patients and higher cancer recurrence rate in surgical oncology patients after allogeneic blood transfusions highlighted a previously underestimated side-effect: transfusion-related immunomodulation (TRIM). The precise pathomechanism still remains uncertain; however, its mostly deleterious effects--such as a higher incidence of postoperative or nosocomial infections--is increasingly accepted. Although transfusion-related immunomodulation is thought to be mediated mainly by donor white blood cells, the benefit of leukoreduction on overall mortality and on infectious complications is highly debatable. Transfusion-transmissible infections and Transfusion-related immunomodulation Transfusion-transmissible infections and Transfusion-related immunomodulation AbstractThe risk of acquiring a transfusion-transmitted infection has declined in recent years.

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“…However, the two Canadian studies 29,30 could not attribute any improved outcomes observed post-universal WBC reduction to the introduction of the intervention per se. 31 In fact, other observational, before-and-after studies that made similar comparisons between patients transfused before or after implementation of universal WBC reduction in France 32 or England 33 reached different conclusions, and the findings of Hébert et al 29 and Fergusson et al 30 contrast sharply with the results of the RCT of Dzik et al 34 that assessed the benefits of universal WBC reduction in a prospective and experimental manner. Thus, the two Canadian studies 29,30 generated evidence of no harm that is valuable for countries that have already implemented universal WBC reduction.…”

Section: Summary and Discussionmentioning

confidence: 97%