The Effect of Transcutaneous Electrical Acupoint Stimulation on Inflammatory Response in Patients Undergoing Limb Ischemia-Reperfusion

Mo, Yunchang; Chen, Si-Jia; Yang, Lili; Huang, Ledan; Jin, Dan; Yu, Zhi Ling; Wang, Leilei; Wang, Liangrong; Luo, Shuai; Wang, Junlu

doi:10.1155/2017/8369737

Cited by 21 publications

(16 citation statements)

References 37 publications

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“…Our result is in line with previous studies showing that transcutaneous electrical acupoint stimulation (TEAS) diminished the upregulation of pro-inflammatory factors in response to lower limb ischemiareperfusion in patients undergoing limb ischemia-reperfusion [29]. Moreover, in animal experimental studies it has been shown that acupuncture intervention have positive roles in relieving inflammatory reaction in rheumatoid arthritis by suppressing myocardial inflammatory cytokines (suppressing TNFα, IL-8, etc.…”

Section: Safetysupporting

confidence: 92%

Effect of Electro-acupuncture (EA) and Manual Acupuncture (MA) on Markers of Inflammation in knee osteoarthritis

Shi

Wang

Yang

et al. 2019

Preprint

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Background Inflammation plays a significant role in the pathogenesis of knee osteoarthritis (KOA). Although both Electro-acupuncture (EA) and Manual Acupuncture (MA) are known to influence systemic inflammation, little is known about the potential changes in inflammation as a working mechanism of EA and MA in KOA.Methods Data from the Acupuncture for Knee Osteoarthritis Trial (ATKOA) were used. Serum concentrations of inflammatory factors (tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-8, IL-18, IL-4, IL-10,IL-13,IL-15, IL-17, monocyte chemotactic protein-1 (MCP-1), CCchemokine ligand 5 (CCL5), and cartilage degradation biomarkers (matrix metalloproteinase-1 MMP-1, MMP-3, MMP-13 and cartilage oligomeric matrix protein COMP) were measured at baseline and after 8 weeks of treatment. Clinical outcomes were valid and reliable self-reported pain and function measures for osteoarthritis using the Western Ontario and McMasters osteoarthritis index questionnaire (WOMAC) and Visual Analogue Scale (VAS) at baseline and post-treatment.Results Both 8-weeks EA and MA significantly reduced pro-inflammatory cytokines (TNFα, IL-1β) and cartilage degradation biomarkers (MMP-3, MMP-13), significantly increased the anti-inflammatory cytokine IL-13 compared with pre-treatment (p<0.05). Further, the reduction of TNF-α were more significant in EA when compared to MA (p=0.046). While, there was no significant difference between groups in cytokines IL-1β (p=0.102), MMP-3(p=0.113), MMP-13(p=0.623) or IL-13(p=0.935). Moreover, in both EA and MA the effect of acupuncture on the VAS and WOMAC function scale after 8 weeks is clinically important, although no significant differences were found between groups.Conclusions 8 weeks of both EA and MA seem to provide improvement in pain relief and function among individuals with mild to moderate knee OA. This benefit is partly mediated by changes of major inflammatory factors TNF-α, IL-1β and IL-13.

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Section: Safetysupporting

confidence: 92%

Effect of Electro-acupuncture (EA) and Manual Acupuncture (MA) on Markers of Inflammation in knee osteoarthritis

Shi

Wang

Yang

et al. 2019

Preprint

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“…ST36 and SP6 are two main anti-inflammatory EA points. Our previous clinical studies demonstrated that transcutaneous electrical acupoint stimulation at the ST36 and SP6 acupoints could inhibit the inflammatory response in the patients undergoing limb ischemia-reperfusion (33). Torres-rosas et al (34) also revealed that EA pre-treatment at these acupoints could inhibit inflammation in a murine model of sepsis established by cecal ligation and puncture or lipopolysaccharide.…”

Section: Discussionmentioning

confidence: 95%

Electroacupuncture pre‑conditioning protects from lung injury induced by limb ischemia/reperfusion through TLR4 and NF‑κB in rats

Lou

et al. 2020

Mol Med Rep

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limb ischemia/reperfusion (i/r) can induce inflammation, causing acute lung injury. The Toll-like receptor 4 (Tlr4)/nF-κB pathway plays an important role in acute and chronic inflammatory disorders. Several studies have demonstrated the efficacy of acupuncture in lung inflammatory injury. The aim of the present study was to elucidate the mechanism underlying the protective effect of electroacupuncture (ea) against lung injury induced by limb i/r. ea applied at the Zusanli and Sanyinjiao acupoints attenuated lung injury and decreased the secretion of inf lammatory factors such as tumor necrosis factor-α, interleukin (il)-1, il-6 and myeloperoxidase. Moreover, the expression levels of TLR4 and NF-κB were suppressed by EA. Thus, the present findings suggested that EA can reduce pulmonary inflammation induced by limb I/R injury, possibly via the inhibition of the TLR4/NF-κB pathway.

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“…Our result is in line with previous studies showing that transcutaneous electrical acupoint stimulation (TEAS) diminished the upregulation of pro-inflammatory factors in response to lower limb ischemia-reperfusion in patients undergoing limb ischemia-reperfusion. 29 Moreover, in animal experimental studies it has been shown that acupuncture intervention has positive roles in relieving inflammatory reaction in rheumatoid arthritis by suppressing myocardial inflammatory cytokines (suppressing TNF-α, IL-8, etc. ), adjusting inflammatory reaction pathway.…”

Section: Discussionmentioning

confidence: 99%

<p>Effect of Electro-Acupuncture (EA) and Manual Acupuncture (MA) on Markers of Inflammation in Knee Osteoarthritis</p>

Shi¹,

Tu²,

Wang³

et al. 2020

JPR

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Background: Inflammation plays a significant role in the pathogenesis of knee osteoarthritis (KOA). Although both electro-acupuncture (EA) and manual acupuncture (MA) are known to influence systemic inflammation, little is known about the potential changes in inflammation as a working mechanism of EA and MA in KOA. Methods: Data from the Acupuncture for Knee Osteoarthritis Trial (ATKOA) were used. Serum concentrations of inflammatory factors (tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-8, IL-18, IL-4, IL-10, IL-13, IL-15, IL-17, monocyte chemotactic protein-1 (MCP-1), CC-chemokine ligand 5 (CCL5), and cartilage degradation biomarkers (matrix metalloproteinase-1 MMP-1, MMP-3, MMP-13 and cartilage oligomeric matrix protein COMP)) were measured at baseline and after 8 weeks of treatment. Clinical outcomes were valid and reliable self-reported pain and function measures for osteoarthritis using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and visual analogue scale (VAS) at baseline and post-treatment. Results: Both 8-weeks EA and MA significantly reduced pro-inflammatory cytokines (TNFα, IL-1β), and cartilage degradation biomarkers (MMP-3, MMP-13) significantly increased the anti-inflammatory cytokine IL-13 compared with pre-treatment (p<0.05). Further, the reduction of TNF-α was more significant in EA when compared to MA (p=0.046). While there was no significant difference between groups in cytokines IL-1β (p=0.102), MMP-3 (p=0.113), MMP-13 (p=0.623) or IL-13 (p=0.935). Moreover, in both EA and MA, the effect of acupuncture on the VAS and WOMAC function scale after 8 weeks is clinically important, although no significant differences were found between groups. Conclusion: Eight weeks of both EA and MA seem to provide improvement in pain relief and function among individuals with mild to moderate knee OA. This benefit is partly mediated by changes of major inflammatory factors TNF-α, IL-1β and IL-13. Trial Registration: Controlled-Trials.com Identifier: NCT03274713.

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The Effect of Transcutaneous Electrical Acupoint Stimulation on Inflammatory Response in Patients Undergoing Limb Ischemia-Reperfusion

Cited by 21 publications

References 37 publications

Effect of Electro-acupuncture (EA) and Manual Acupuncture (MA) on Markers of Inflammation in knee osteoarthritis

Effect of Electro-acupuncture (EA) and Manual Acupuncture (MA) on Markers of Inflammation in knee osteoarthritis

Electroacupuncture pre‑conditioning protects from lung injury induced by limb ischemia/reperfusion through TLR4 and NF‑κB in rats

<p>Effect of Electro-Acupuncture (EA) and Manual Acupuncture (MA) on Markers of Inflammation in Knee Osteoarthritis</p>

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