The effect of tocolytic use in the management of symptomatic placenta previa

Besinger, Richard E.; Moniak, Charles W.; Paskiewicz, Linda S.; Fisher, Susan G.; Tomich, Paul G.

doi:10.1016/0002-9378(95)91410-2

Cited by 49 publications

(20 citation statements)

References 8 publications

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“…With the introduction of routine ultrasound scan in the second trimester of pregnancy more cases of placenta praevia are now detected, even before they become symptomatic (Benedetti, 1991;Besinger et al, 1995). Ritzos et al (1979) and Gillieson et al (1982) reported that 5 -6% of placentae were found to be low-lying in the second trimester.…”

Section: Discussionmentioning

confidence: 96%

From low-lying implantation to placenta praevia: a longitudinal ultrasonic assessment

Chama

Wanonyi

Usman

2004

Journal of Obstetrics and Gynaecology

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A study of 895 consecutive pregnant women studied by transabdominal ultrasound scan showed an incidence of 14.6% of low-lying placenta at 12-14 weeks' gestation. Longitudinal follow-up of those with low-lying placenta showed that 85% of them had normally situated placenta at term. However, for those with partial or total placenta praevia at 30 weeks' gestation, 60% and 75%, respectively, persisted as major placenta praevia at term. A total of 45% of those with low-lying placenta at recruitment had threatened abortion while 15.7% had antepartum haemorrhage. The caesarean section rate was as high as 26% among the study population compared with 8.4% among the general population (P < 0.005). It is recommended that all antenatal women should have at least one ultrasound scan in the second or third trimester for placental localisation. Those found to have major placenta praevia in the third trimester should be closely followed-up.

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Section: Discussionmentioning

confidence: 96%

From low-lying implantation to placenta praevia: a longitudinal ultrasonic assessment

Chama

Wanonyi

Usman

2004

Journal of Obstetrics and Gynaecology

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“…Richard E and Besinger et al 17 in 1995 found that tocolytic intervention in cases of symptomatic preterm previa associated with clinically significant prolongation of pregnancy i.e admission to delivery (39.2 vs 26.9 days, p < 0.02) and increased birth weight (2520 vs 2124 gm, p < 0.03). Tocolytic therapy in these cases does not appear to have an impact on frequency or severity of recurrent vaginal bleeding.…”

Section: Resultsmentioning

confidence: 99%

“…[13][14][15] Study related to use of progesterone in expectant management of symptomatic placenta is very limited. 16,17 AIMS AND OBJECTIVES: The objective of our study is to determine the effectiveness of intramuscular 17α hydroxy progesterone caproate therapy versus placebo in conservative management of patients with symptomatic placenta previa before 34 weeks of gestation. Primary outcome measure was prolongation of pregnancy and secondary outcome measures were maternal outcomes i.e.…”

Section: Introductionmentioning

confidence: 99%

Randomised Control Study of Use of Progesterone v / S Placebo for Management of Symptomatic Placenta Previa Before 34 Weeks of Gestation in a Tertiary Care Centre

Chattopadhyay¹,

Roy²,

Mandal³

et al. 2015

jemds

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INTRODUCTION:APH complicates 3-5% of pregnancies and is a leading cause of perinatal and maternal mortality worldwide. Progesterone is essential in maintenance of pregnancy and helps in prolongation of pregnancy. Different trials have been done to show the efficacy and safety of progesterone in prevention of preterm birth but study related to use in expectant management of symptomatic placenta previa is very limited. AIMS AND OBJECTIVE: The objective of our study is to determine the effectiveness of intramascular 17 alpha hydroxy progesterone Caproate therapies vs. placebo in conservative management of patient with symptomatic placenta previa before 34 weeks of gestation. MATERIALS AND METHODS: It is a randomized control study with 100 pregnant women attending Obstetric deptt. at Nilratan Sircar Medical College and Hospital, Kolkata with symptomatic placenta previa having episode of warning haemorrhage before 34 weeks of gestation and fulfilling inclusion criteria were enrolled for the study in a two year period from January 2013 to December 2014. Statistical analysis was performed using student t-test and chaisquare test where appropriate. RESULTS AND ANALYSIS: In our study prolongation of pregnancy in progesterone receiving group is statistically significant (p-value<0.001), significant difference were also found in gestational age at delivery (p value of 0.0288), birth-weight (p-value of 0.0470). CONCLUSION: In this study use of 17 alpha hydroxy progesterone in expectant management of symptomatic placenta previa tends to be beneficial than placebo.

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“…Management options vary from expectant management to urgent cesarean delivery. Some retrospective studies have demonstrated that the use of tocolysis is associated with greater prolongation of pregnancy and higher birth weights [39,40].…”

Section: Placenta Previamentioning

confidence: 99%