The Effect of Tissue Plasminogen Activator on Retinal Bleeding

Subconjunctival High Dose Plasminogen Activator in Rabbit Filtration Surgery

“…These findings correlate well with our morphometric demonstration of decreased episcleral fibrosis in treated animals though our technique is much less precise than histo-chemical analysis would be. Of interest is the fact that intraocular hemorrhage was not associated with the dose of t-PA used in our study though other investigators have reported an increase in intraocular hemorrhage associated with the administration of lower doses of t-PA than those used in our study (29,30).…”

Subconjunctival High Dose Plasminogen Activator in Rabbit Filtration Surgery

“…These findings correlate well with our morphometric demonstration of decreased episcleral fibrosis in treated animals though our technique is much less precise than histo-chemical analysis would be. Of interest is the fact that intraocular hemorrhage was not associated with the dose of t-PA used in our study though other investigators have reported an increase in intraocular hemorrhage associated with the administration of lower doses of t-PA than those used in our study (29,30).…”

New treatments in age‐related macular degeneration

“…Although less traumatic than surgical evacuation of submacular haemorrhage, retinal breaks and detachment, vitreous haemorrhage and endophthalmitis have been reported 125,136 . In addition, dose‐related pigmentary retinopathy secondary to tPA arginine buffer toxicity has occurred 138,140−142 , and tPA‐induced re‐bleeding may occur if it is injected within 72 h of the original haemorrhage 136,143 .…”

Subconjunctival High Dose Plasminogen Activator in Rabbit Filtration Surgery

“…These findings correlate well with our morphometric demonstration of decreased episcleral fibrosis in treated animals though our technique is much less precise than histo-chemical analysis would be. Of interest is the fact that intraocular hemorrhage was not associated with the dose of t-PA used in our study though other investigators have reported an increase in intraocular hemorrhage associated with the administration of lower doses of t-PA than those used in our study (29,30).…”

New treatments in age‐related macular degeneration

“…Although less traumatic than surgical evacuation of submacular haemorrhage, retinal breaks and detachment, vitreous haemorrhage and endophthalmitis have been reported 125,136 . In addition, dose‐related pigmentary retinopathy secondary to tPA arginine buffer toxicity has occurred 138,140−142 , and tPA‐induced re‐bleeding may occur if it is injected within 72 h of the original haemorrhage 136,143 .…”

Subconjunctival High Dose Plasminogen Activator in Rabbit Filtration Surgery

“…These findings correlate well with our morphometric demonstration of decreased episcleral fibrosis in treated animals though our technique is much less precise than histo-chemical analysis would be. Of interest is the fact that intraocular hemorrhage was not associated with the dose of t-PA used in our study though other investigators have reported an increase in intraocular hemorrhage associated with the administration of lower doses of t-PA than those used in our study (29,30).…”

New treatments in age‐related macular degeneration

“…Although less traumatic than surgical evacuation of submacular haemorrhage, retinal breaks and detachment, vitreous haemorrhage and endophthalmitis have been reported 125,136 . In addition, dose‐related pigmentary retinopathy secondary to tPA arginine buffer toxicity has occurred 138,140−142 , and tPA‐induced re‐bleeding may occur if it is injected within 72 h of the original haemorrhage 136,143 .…”