The Effect of Tetrahydroisoxazolopyridinol (THIP) in Tardive Dyskinesia

GABA and Glutamate Receptors as Therapeutic Targets in Neurodegenerative Disorders*

“…of 4-PIOL (Kristiansen et al 1991). The response to 1 mM 4-PIOL was blocked by bicuculline methobromide, which strongly indicates that 4-PIOL is acting at the GABAA receptor.…”

GABA and Glutamate Receptors as Therapeutic Targets in Neurodegenerative Disorders*

“…of 4-PIOL (Kristiansen et al 1991). The response to 1 mM 4-PIOL was blocked by bicuculline methobromide, which strongly indicates that 4-PIOL is acting at the GABAA receptor.…”

Effects of early-life exposure to THIP on phenotype development in a mouse model of Rett syndrome

“…Another preclinical study in humans, rats, and mice shows a rapid and complete absorption of THIP with the peak concentration reached within 0.5 h in several organs include the brain [ 29 ]. A clinical report indicates that therapeutic dosages of THIP by long-term oral administration range from 20 to 120 mg daily in human patients [ 45 ]. Higher doses of THIP may cause adverse side effects, including sedation, confusion, and dizziness [ 14 ].…”

Evaluation of THIP in standard tests for analgesic activity: Occurrence of antinociception and hyperalgesia

“…The occurrence of vomiting and myoclonic jerks in monkeys are further undesirable aspects of THIP. Reports from the clinical trials in which THIP has been studied in patients with anxiety and tardive dyskinesia have noted sedation, confusion, dizziness, vomiting, and myoclonic jerks as side-effects [Korsgaard et al, 1982;Hoehn-Saric, 19821.…”

GABA and Glutamate Receptors as Therapeutic Targets in Neurodegenerative Disorders*

“…of 4-PIOL (Kristiansen et al 1991). The response to 1 mM 4-PIOL was blocked by bicuculline methobromide, which strongly indicates that 4-PIOL is acting at the GABAA receptor.…”

Effects of early-life exposure to THIP on phenotype development in a mouse model of Rett syndrome

“…Another preclinical study in humans, rats, and mice shows a rapid and complete absorption of THIP with the peak concentration reached within 0.5 h in several organs include the brain [ 29 ]. A clinical report indicates that therapeutic dosages of THIP by long-term oral administration range from 20 to 120 mg daily in human patients [ 45 ]. Higher doses of THIP may cause adverse side effects, including sedation, confusion, and dizziness [ 14 ].…”

Evaluation of THIP in standard tests for analgesic activity: Occurrence of antinociception and hyperalgesia

“…The occurrence of vomiting and myoclonic jerks in monkeys are further undesirable aspects of THIP. Reports from the clinical trials in which THIP has been studied in patients with anxiety and tardive dyskinesia have noted sedation, confusion, dizziness, vomiting, and myoclonic jerks as side-effects [Korsgaard et al, 1982;Hoehn-Saric, 19821.…”

GABA and Glutamate Receptors as Therapeutic Targets in Neurodegenerative Disorders*

“…of 4-PIOL (Kristiansen et al 1991). The response to 1 mM 4-PIOL was blocked by bicuculline methobromide, which strongly indicates that 4-PIOL is acting at the GABAA receptor.…”

Effects of early-life exposure to THIP on phenotype development in a mouse model of Rett syndrome

“…Another preclinical study in humans, rats, and mice shows a rapid and complete absorption of THIP with the peak concentration reached within 0.5 h in several organs include the brain [ 29 ]. A clinical report indicates that therapeutic dosages of THIP by long-term oral administration range from 20 to 120 mg daily in human patients [ 45 ]. Higher doses of THIP may cause adverse side effects, including sedation, confusion, and dizziness [ 14 ].…”

Evaluation of THIP in standard tests for analgesic activity: Occurrence of antinociception and hyperalgesia

“…The occurrence of vomiting and myoclonic jerks in monkeys are further undesirable aspects of THIP. Reports from the clinical trials in which THIP has been studied in patients with anxiety and tardive dyskinesia have noted sedation, confusion, dizziness, vomiting, and myoclonic jerks as side-effects [Korsgaard et al, 1982;Hoehn-Saric, 19821.…”