2020
DOI: 10.3390/ijms21114016
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Abstract: Acrylic bone cement is widely used in orthopedic surgery for treating various conditions of the bone and joints. Bone cement consists of methyl methacrylate (MMA), polymethyl methacrylate (PMMA), and benzoyl peroxide (BPO), functioning as a liquid monomer, solid phase, and polymerization initiator, respectively. However, cell and tissue toxicity caused by bone cement has been a concern. This study aimed to determine the effect of tri-n-butyl borane (TBB) as an initiator on the biocompatibility of bone cement. … Show more

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Cited by 19 publications
(29 citation statements)
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“…This study also assessed the polymerizing behavior of the materials using an established ESR to measure free radical production [ 20 , 30 ], with the results firmly supporting other cell culture experiments. It was surprising that PMMA-BPO maintained some cytotoxicity even on seven-day-old specimens, considering that the culture medium was replaced every three days.…”
Section: Discussionsupporting
confidence: 62%
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“…This study also assessed the polymerizing behavior of the materials using an established ESR to measure free radical production [ 20 , 30 ], with the results firmly supporting other cell culture experiments. It was surprising that PMMA-BPO maintained some cytotoxicity even on seven-day-old specimens, considering that the culture medium was replaced every three days.…”
Section: Discussionsupporting
confidence: 62%
“…This explains why toxicity remains even after changing culture media every three days on PMMA-BPO cements. Hypothetical chemical structures have been proposed for PMMA-BPO and PMMA-TBB cements, but the exact mechanism during polymerization is unknown for both materials [ 19 , 20 , 30 , 46 ]. Further studies are required to identify the mechanism behind the remarkably reduced production of radicals in PMMA-TBB.…”
Section: Discussionmentioning
confidence: 99%
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“…The number of osteoblasts attached to the zirconia surfaces during the initial stage of culture was evaluated using a tetrazolium salt (WST-1)-based colorimetric assay (WST-1; Roche Applied Science, Mannheim, Germany) on day 2 of culture as described elsewhere [16,34,45,60]. To evaluate the proliferative activity of osteoblasts, the density of propagated cells was also quantified using a WST-1 assay on day 5.…”
Section: Osteoblast Attachment and Proliferation Assaysmentioning
confidence: 99%