The effect of sperm DNA fragmentation on in vitro fertilization outcomes of unexplained infertility

Wang, Qingxin; Gu, Xiuli; Chen, Yannan; Yu, Minyan; Peng, Lingna; Zhong, Shuping; Wang, Xia; Lv, Jinxing

doi:10.1016/j.clinsp.2023.100261

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…70 In agreement with these results, a recent retrospective study involving 176 couples with unexplained infertility undergoing IVF or ICSI showed that SDF levels >25% were significantly correlated with a decrease in the number of day 3 good-quality embryos ( r = −0.347, p < 0.001). 71 In contrast to these findings, previous systematic reviews that gathered evidence from numerous sources did not establish a clear association. For instance, in a 2011 systematic review evaluating a total of 3,226 IVF and ICSI cycles, SDF was linked to poor embryo quality in less than half of the included studies (11/28), 43 a finding corroborated by Simon et al in 2017.…”

Section: Sperm Dna Fragmentation and Assisted Reproductive Technologymentioning

confidence: 71%

Unraveling the Impact of Sperm DNA Fragmentation on Reproductive Outcomes

Nielsen,

Majzoub,

Esteves

et al. 2023

Semin Reprod Med

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In recent years, there has been a growing interest in identifying subcellular causes of male infertility, and sperm DNA fragmentation (SDF) research has been at the forefront of this focus. DNA damage can occur during spermatogenesis due to faulty chromatin compaction or excessive abortive apoptosis. It can also happen as sperm transit through the genital tract, often induced by oxidative stress. There are several methods for SDF testing, with the sperm chromatin structure assay, terminal deoxynucleotidyl transferase d-UTI nick end labeling (TUNEL) assay, comet assay, and sperm chromatin dispersion test being the most commonly used. Numerous studies strongly support the negative impact of SDF on male fertility potential. DNA damage has been linked to various morphological and functional sperm abnormalities, ultimately affecting natural conception and assisted reproductive technology outcomes. This evidence-based review aims to explore how SDF influences male reproduction and provide insights into available therapeutic options to minimize its detrimental impact.

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Section: Sperm Dna Fragmentation and Assisted Reproductive Technologymentioning

confidence: 71%

Unraveling the Impact of Sperm DNA Fragmentation on Reproductive Outcomes

Nielsen,

Majzoub,

Esteves

et al. 2023

Semin Reprod Med

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show abstract

“…Table 2 summarizes the characteristics of a total of 54208 IUI cycles (excluding 32 cycles of lost visits) with 7773 clinical pregnancy outcomes in these 23 studies. Deary 1997 [19] (1992-1995) Hill 2013 [21] ( Monseur 2019 [24] (1999-2017) Guo Yu-rui 2016 [29] ( Yin Ming-na 2014 [30] ( Li Jing 2010 [32] ( Li Si-Chen 2016 [33] ( Li Hong-xia 2020 [34] ( Li Jing 2014 [35] (2012-2013) Wang Gang 2017 [37] ( Guo Jianghua 2007 [39] (…”

Section: Basic Characteristics Of the Included Literaturementioning

confidence: 99%

Correlation between the times of IUI and pregnancy outcome: a systematic review and meta-analysis with trial sequential analysis of cohort study

Yu,

Wei,

Yuan

et al. 2023

Preprint

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Purpose the study aims to evaluate whether increasing the times of IUI per cycle has better pregnancy outcomes for infertile couples. Methods PubMed, Embase, Web of science, Cochrane Library, CNKI, WanFang Data, VIP (VIP Chinese Journal Service Platform), and SinoMed (China Biomedical Literature Service), were systematically retrieved cohort studies about the times of IUI per cycle and pregnancy outcomes published before December 31, 2021. Included studies were assessed by Newcastle-Ottawa Scale (NOS) with two reviewers. The data was processed with RevMan 5.4.1 and the result of the meta-analysis were further examined by TSA 0.9.5.10 Beta version. Results 23 cohort studies with 54208 IUI cycles were included in this study. Meta-analysis of the data reported in these 23 studies showed that the cycle pregnancy rates were higher in the double insemination group (double IUI) than in the single insemination group (single IUI) [RR = 1.14, 95% CI (1.02, 1.27), I2 = 64%, P = 0.02]. Sensitivity analysis showed that the results were stable and reliable. The bias analysis showed that there was a low possibility of publication bias in this study. TSA of 23 trials illustrate that the cumulative z-curve crossed the traditional boundary, the trial sequential monitoring boundary and the required information size(RIS). Conclusion compared with single IUI, double IUI per cycle can increase the cycle pregnancy rates to a small extent without increasing the incidence of biochemical pregnancy, miscarriage, or ectopic pregnancy. The results should be treated with caution and other factors should be taken into consideration when making clinical decisions.

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Integrating artificial intelligence into the modernization of traditional Chinese medicine industry: a review

Zhou,

Shen,

Hou

2024

Front. Pharmacol.

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Traditional Chinese medicine (TCM) is the practical experience and summary of the Chinese nation for thousands of years. It shows great potential in treating various chronic diseases, complex diseases and major infectious diseases, and has gradually attracted the attention of people all over the world. However, due to the complexity of prescription and action mechanism of TCM, the development of TCM industry is still in a relatively conservative stage. With the rise of artificial intelligence technology in various fields, many scholars began to apply artificial intelligence technology to traditional Chinese medicine industry and made remarkable progress. This paper comprehensively summarizes the important role of artificial intelligence in the development of traditional Chinese medicine industry from various aspects, including new drug discovery, data mining, quality standardization and industry technology of traditional Chinese medicine. The limitations of artificial intelligence in these applications are also emphasized, including the lack of pharmacological research, database quality problems and the challenges brought by human-computer interaction. Nevertheless, the development of artificial intelligence has brought new opportunities and innovations to the modernization of traditional Chinese medicine. Integrating artificial intelligence technology into the comprehensive application of Chinese medicine industry is expected to overcome the major problems faced by traditional Chinese medicine industry and further promote the modernization of the whole traditional Chinese medicine industry.

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The effect of sperm DNA fragmentation on in vitro fertilization outcomes of unexplained infertility

Cited by 4 publications

References 27 publications

Unraveling the Impact of Sperm DNA Fragmentation on Reproductive Outcomes

Unraveling the Impact of Sperm DNA Fragmentation on Reproductive Outcomes

Correlation between the times of IUI and pregnancy outcome: a systematic review and meta-analysis with trial sequential analysis of cohort study

Integrating artificial intelligence into the modernization of traditional Chinese medicine industry: a review

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