The effect of some inhibitors on the nucleation and crystal growth of apatite

Bachra, Bernard N.; Fischer, H. R. A.

doi:10.1007/bf02058677

Cited by 82 publications

(22 citation statements)

References 19 publications

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“…Bachra and Fischer [1969] reported that Sr can slow down HAp crystal growth, which was supported by other studies for HAp [Koutsoukos and Nancollas, 1981;Christoffersen et al 1997;Verberckmoes et al, 2004], for ACP [Root, 1990;Hidaka et al, 1991], for ACP to OCP to HAp conversions [Markovic and Brecevic, 1992], and for the α-tricalcium phosphate to HAp conversion [Boanini et al, 2010]. Bigi et al [1988] suggested that Sr does not 'greatly affect' the conversion of OCP and BR into HAp, but stilland to a lesser extent than Mg. Sr can, however, also be seen to stabilize HAp precursor phases [Matsunaga and Murata, 2009] and therefore to increase the number of biological nucleation sites [Drouet et al, 2008].…”

Section: Sr and Capisupporting

confidence: 70%

Strontium and Caries: A Long and Complicated Relationship

Lippert

Hara²

2012

Caries Res

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Investigations into the role of strontium (Sr) in caries prevention have attracted great interest in the research community in the past, with its peak in the 1970-and 80ies. To this date, no clear indication of the relative importance of Sr in caries prevention has been provided. A vast number of animal caries, epidemiological and mechanistic studies have been conducted. Albeit Although a great level ofthere is much discrepancyexists in the literature, the majority of studies suggest that Sr exhibits some cariostatic properties and, predominantly in the presence of fluoride (F). An optimum Sr concentration of 5 to 10 ppm in drinking water has been proposed as a direct result of several epidemiological caries studies. Despite these results, no direct link can be established between Sr and caries prevention as, to date, no relevant, randomized control trials have been reported. The extrapolation of potential cariostatic properties of Sr from epidemiological studies is difficult due to the co-presence of several other trace elements in the water of the study areas, with many of these elements being attributed cariostatic properties in their own right.

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Section: Sr and Capisupporting

confidence: 70%

Strontium and Caries: A Long and Complicated Relationship

Lippert

Hara²

2012

Caries Res

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“…Increased magnesium, if located in the Helmholz double layer, could provide cationic bridging for proteins. This does not exclude the possibility that increased magnesium per se could impair growth [Bachra and Fischer, 1969].…”

Section: Matrix-mineral Interactionsmentioning

confidence: 99%

“…These are often said to be stabilised by carbonate or magnesium. Whatever the nature of this phase, there seems to be general agreement that the presence of fluoride ion during initial deposition can delay formation of an initial apatite precursor, proba-Robinson/Connell/Kirkham/Brookes/ Shore/Smith bly by stabilising very early precursor entities [Bachra and Fischer, 1969]. Work by Bronckers et al [1984b] using hamster tooth germs is consistent with this view and showed that protein matrix formed under an elevated fluoride regime did not mineralise at all unless fluoride was removed, indicating a reversible effect on the matrixassociated initiation process.…”

Section: Initiation Of Precipitation During Secretionmentioning

confidence: 99%

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The Effect of Fluoride on the Developing Tooth

et al. 2004

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This review aims to outline the effects of fluoride on the biological processes involved in the formation of tooth tissues, particularly dental enamel. Attention has been focused on mechanisms which, if compromised, could give rise to dental fluorosis. The literature is extensive and often confusing but a much clearer picture is emerging based on recent more detailed knowledge of odontogenesis. Opacity, characteristic of fluorotic enamel, results from incomplete apatite crystal growth. How this occurs is suggested by other changes brought about by fluoride. Matrix proteins, associated with the mineral phase, normally degraded and removed to permit final crystal growth, are to some extent retained in fluorotic tissue. Fluoride and magnesium concentrations increase while carbonate is reduced. Crystal surface morphology at the nano-scale is altered and functional ameloblast morphology at the maturation stage also changes. Fluoride incorporation into enamel apatite produces more stable crystals. Local supersaturation levels with regard to the fluoridated mineral will also be elevated facilitating crystal growth. Such changes in crystal chemistry and morphology, involving stronger ionic and hydrogen bonds, also lead to greater binding of modulating matrix proteins and proteolytic enzymes. This results in reduced degradation and enhanced retention of protein components in mature tissue. This is most likely responsible for porous fluorotic tissue, since matrix protein removal is necessary for unimpaired crystal growth. To resolve the outstanding problems of the role of cell changes and the precise reasons for protein retention more detailed studies will be required of alterations to cell function, effect on specific protein species and the nano-chemistry of the apatite crystal surfaces.

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“…Dedhiya et al 7) indicated the formation of Ca-Sr apatite surface complex on synthetic hydroxyapatite under conditions resembling cariogenic attacks, and suggested the surface complex could govern the driving force of the dissolution reaction. The other studies reported Sr incorporation can slow down hydroxyapatite crystal growth 8) and stabilize hydroxyapatite precursor phases 9) . Sr, therefore, can increase the number of biological nucleation sites 10) .…”

Section: Introductionmentioning

confidence: 97%

A new technique for analyzing trace element uptake by human enamel

et al. 2015

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Fluorine (F) and strontium (Sr) are key elements in the de-and remineralization of teeth. To quantitatively analyze the distribution of F and Sr, micro-particle-induced gamma/X-ray emission (PIGE/PIXE) technique was used. The cavities were prepared and filled with the fluoride-and Sr-containing restorative materials (FSCMs) in extracted human molars. The single-section enamel specimens were prepared by slicing from the buccal to lingual surface including the FSCMs. After 5 weeks of automatic pH cycling, the demineralization was calculated by integrated mineral loss (ΔIML) from transverse-microradiography. The distributions of F and Sr were analyzed by the PIGE/PIXE technique. The micro-PIGE/PIXE technique indicated a fluorine uptake difference between the enamel surface and enamel cavity wall. ΔIML of FSCMs were significantly lower than intact enamel. The micro-PIGE/PIXE technique enables measurement of F and Sr uptake from FSCMs into enamel, which would be beneficial for research on caries development and prevention.

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The effect of some inhibitors on the nucleation and crystal growth of apatite

Cited by 82 publications

References 19 publications

Strontium and Caries: A Long and Complicated Relationship

Strontium and Caries: A Long and Complicated Relationship

The Effect of Fluoride on the Developing Tooth

A new technique for analyzing trace element uptake by human enamel

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