The effect of smoking on inflammatory cell infiltrate subtypes in gingival tissue of patients with chronic periodontitis

Radvar, Mehrdad; Shafaee, Hooman; Mohtasham, Nooshin; Shiezadeh, Farid; Zamanpour, Mona

doi:10.19082/4961

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…O tabagismo demonstra estar relacionado ao desiquilíbrio microbiano subgengival (Moon et al, 2015;Coretti et al, 2017) e à resposta imunológica inflamatória do indivíduo (Moon et al, 2015;Munz et al, 2017;Radvar et al, 2017). A partir da revisão sistemática realizada por Leite, Nascimento, Scheutz e Lopez (2018), evidencia-se o importante papel do tabagismo na incidência e progressão da doença periodontal, atuando, também, na perda óssea e nível de inserção.…”

Section: Discussionunclassified

Condição periodontal associada à prática de higiene bucal e ao hábito de fumar de pacientes do serviço de periodontia da Universidade Estadual da Paraíba

Santos

Brito²,

Monteiro³

et al. 2022

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O objetivo deste trabalho é avaliar a condição periodontal de pacientes atendidos na clínica escola de Odontologia da Universidade Estadual da Paraíba – UEPB, campus I, Campina Grande, Paraíba, investigando sua associação com as características comportamentais e hábitos da população estudada. Trata-se de um estudo transversal, quantitativo e analítico a partir de prontuários odontológicos. Utilizou-se como critérios de exclusão a incompletude de dados ou a falta de assinatura do TCLE pelo paciente. As análises foram realizadas pelo SPSS 20.0. Para caracterizar a população, distribuiu-se as frequências dos dados. Para associar a condição periodontal (gengivite/periodontite) e as demais variáveis empregou-se o teste qui-quadrado de Pearson (ou teste exato de Fisher quando apropriado), com p < 0,05. Do total de 426 prontuários, 42,5% foram excluídos, restando 245 prontuários. A frequência de tabagistas foi de 10,6% e de ex-tabagistas de 22,0%. Em relação à queixa principal, 68,6% procuraram atendimento por motivos não relacionados à doença periodontal. Sobre a prática de higiene bucal, 121 (49,4%) afirmaram escovar os dentes 3 vezes ao dia e 124 (50,6%), usar fio dental. Porém, a avaliação do índice de placa visível refletiu uma higiene bucal ruim (58,4%). A condição mais prevalente foi de cálculo dentário (63,7%), predominando no sextante 5 (72,7%). A associação entre a condição periodontal e demais variáveis foi estatisticamente significante entre periodontite e tabagismo (p = 0,003). Conclui-se que o relato de prática de higienização bucal adequada não reflete na condição periodontal presente. Observa-se a importância de intensificar ações de orientação em saúde bucal.

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Section: Discussionunclassified

Condição periodontal associada à prática de higiene bucal e ao hábito de fumar de pacientes do serviço de periodontia da Universidade Estadual da Paraíba

Santos

Brito²,

Monteiro³

et al. 2022

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“…According to these results, we may infer that ADRB3 genotype among smokers is a more important factor involved in periodontal disease progression. Previous reports indicated a significant association between smoking and periodontal disease progression (Duque et al, ; Johnson, ; Radvar, Shafaee, Mohtasham, Shiezadeh, & Zamanpour, ). Nicotine is a major harmful substance found in tobacco, and nicotine derivatives are vasoconstrictive on peripheral, coronary, placental and gingival blood vessels.…”

Section: Discussionmentioning

confidence: 92%

Interaction between beta‐3 adrenergic receptor genotype and environmental factors on periodontal progression

Yoshihara

Kaneko

Nohno

et al. 2019

J Clinic Periodontology

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Objectives The purpose of this longitudinal study was to evaluate the relationship between beta‐3 adrenergic receptor polymorphism and environmental factors such as smoking on periodontal disease by considering effect modification. Materials and Methods A total of 294 subjects who participated in all follow‐up surveys over the 6‐year study period were analysed. After dividing subjects into tertiles according to the number of years exposed to smoking, we conducted Poisson regression analysis to compare the incidence rate ratio (IRR) for periodontal disease events during the 6‐year study period with beta‐3 adrenergic receptor genotype (1: Arg allele carriers, 2: Arg allele non‐carriers) for each tertile adjusted for other four variables. Results The number of years exposed to smoking (mean ± standard deviation) for the 1st, 2nd and 3rd tertiles was 0 ± 0, 20.1 ± 9.1 and 45.3 ± 7.7 years, respectively. The IRRs ± SE were 0.89 ± 0.08 (p = 0.218) for the 1st tertile, 1.93 ± 0.36 (p < 0.001) for the 2nd tertile and 2.56 ± 0.23 (p < 0.001) for the 3rd tertile. Conclusion There was a clear dose–response relationship between beta‐3 adrenergic receptor genotype and periodontal disease progression based on the number of years exposed to smoking.

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“…Несмотря на отсутствие зуба и, соответственно, пародонта, общий характер выявленных гистопатологических изменений в мягких тканях соответствует описанной в литературе морфологической картине хронического пародонтита. В частности, выявленное в рамках данного исследования преобладание в воспалительном инфильтрате Т-лимфоцитов (CD3+ клеток) согласуется с данными других исследователей [14,15]. Полученные результаты также согласуются с данными, свидетельствующими о существенной роли Т-лимфоцитов, в частности Т-хелперов (CD4+), в реализации местного иммунного ответа в тканях дес-ны [16,17].…”

Section: результатыunclassified

Immunohistochemical profile of gingiva biopsy samples from the edentulous alveolar ridge in the jaw

Kulikov,

Zhad’ko,

Romanenko

et al. 2024

Parodontologiâ

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Relevance. Despite the high success rate of dental implantation in restoring anatomical occlusion and achieving desired aesthetic effects, complications, often mediated by peri-implantitis, remain an area requiring further study. This study aimed to morphologically assess gingiva biopsy samples from the edentulous alveolar ridge of the jaw, using immunohistochemical markers for immunophenotyping different subpopulations of inflammatory cells, inter alia.Material and methods. Gingiva biopsy specimens from 25 patients underwent descriptive histological and immunohistochemical analyses, employing markers such as CD3, CD20, TBX21, GATA3, Foxp3, CD68, CD80, CD163, CD1a, and CD83. The study includes clinical-anamnestic data analysis, descriptive histological and immunohistochemical observations, and a quantitative analysis of the abundance of various immunopositive cell subpopulations.Results. The data indicated that approximately one third of the gum tissues exhibited signs of a chronic inflammatory response, predominantly characterized by the primary T-cell subpopulation of T-helper 1 cells, a minimal presence of regulatory T-cells, and an almost complete absence of T-helper 2 cells. Additionally, an inflammatory cell mix was observed, comprising a significant proportion of B-cells, monocyte-macrophage cells (mainly M2 macrophage subpopulation), and mature CD83+ dendritic cells. These changes reflect a pro-inflammatory local immune response, crucial to consider in future implantation planning.Conclusion. The analysis of this pilot clinical case series enhances our understanding of the gingiva condition in the edentulous alveolar ridge before dental implantation and opens avenues for further research in this field.

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The effect of smoking on inflammatory cell infiltrate subtypes in gingival tissue of patients with chronic periodontitis

Cited by 6 publications

References 33 publications

Condição periodontal associada à prática de higiene bucal e ao hábito de fumar de pacientes do serviço de periodontia da Universidade Estadual da Paraíba

Condição periodontal associada à prática de higiene bucal e ao hábito de fumar de pacientes do serviço de periodontia da Universidade Estadual da Paraíba

Interaction between beta‐3 adrenergic receptor genotype and environmental factors on periodontal progression

Immunohistochemical profile of gingiva biopsy samples from the edentulous alveolar ridge in the jaw

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