The effect of single or repeated restraint stress on several signal molecules in paraventricular nucleus, arcuate nucleus and locus coeruleus

Kwon, Min-Soo; Seo, Young-Jun; Shim, Eon-Jeong; Choi, Sun-Hye; Lee, J.-Y.; Suh, Hong‐Won

doi:10.1016/j.neuroscience.2006.07.027

Cited by 61 publications

(52 citation statements)

References 74 publications

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“…Given that forebrain GR is of particular importance in limiting CORT responses to psychogenic stressors (Furay et al, 2008), our results suggest that the downregulation of hippocampal GR may cause stressor-specific feedback impairment. However, the reduction of hippocampal GR did not appear to affect fRW-induced facilitation of the HPA axis response in the controls, suggesting that GR in other brain regions or other regulatory mechanisms, such as different circuits or cell populations or metabolic signaling (Dallman et al, 2004;Kwon et al, 2006), are differentially affected by FPI.…”

Section: Molecular Mediators Of Exercise Are Affected By Fpimentioning

confidence: 84%

Differential Effects of Voluntary and Forced Exercise on Stress Responses after Traumatic Brain Injury

Griesbach

Tio

Vincelli

et al. 2012

Journal of Neurotrauma

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Voluntary exercise increases levels of brain-derived neurotrophic factor (BDNF) after traumatic brain injury (TBI) when it occurs during a delayed time window. In contrast, acute post-TBI exercise does not increase BDNF. It is well known that increases in glucocorticoids suppress levels of BDNF. Moreover, recent work from our laboratory showed that there is a heightened stress response after fluid percussion injury (FPI). In order to determine if a heightened stress response is also observed with acute exercise, at post-injury days 0-4 and 7-11, corticosterone (CORT) and adrenocorticotropic hormone (ACTH) release were measured in rats running voluntarily or exposed to two daily 20-min periods of forced running wheel exercise. Forced, but not voluntary exercise, continuously elevated CORT. ACTH levels were initially elevated with forced exercise, but decreased by post-injury day 7 in the control, but not the FPI animals. As previously reported, voluntary exercise did not increase BDNF in the FPI group as it did in the control animals. Forced exercise did not increase levels of BDNF in any group. It did, however, decrease hippocampal glucocorticoid receptors in the control group. The results suggest that exercise regimens with strong stress responses may not be beneficial during the early post-injury period.

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Section: Molecular Mediators Of Exercise Are Affected By Fpimentioning

confidence: 84%

Differential Effects of Voluntary and Forced Exercise on Stress Responses after Traumatic Brain Injury

Griesbach

Tio

Vincelli

et al. 2012

Journal of Neurotrauma

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“…Noise-induced c-Fos mRNA expression in the paraventricular nucleus has been markedly correlated with levels of plasma adrenocorticotropin hormone (43). c-Fos expression in the paraventricular nucleus and locus coeruleus is increased by single restraint and these increments are attenuated by repeated restraint stress (44). Restraint stress enhances c-Fos expression in neurons of the paraventricular nucleus, locus coeruleus, supraoptic nucleus, rostral raphe pallidus, nucleus of the solitary tract and ventrolateral medulla (45).…”

Section: Discussionmentioning

confidence: 99%

Treadmill exercise during pregnancy ameliorates post-traumatic stress disorder-induced anxiety-like responses in maternal rats

Seo

Kim

et al. 2012

Molecular Medicine Reports

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Post‑traumatic stress disorder (PTSD) is an anxiety disorder triggered by life‑threatening events that cause intense fear. Exercise is known to have protective effects on neuropsychiatric diseases. The present study investigated whether treadmill exercise during pregnancy reduced or alleviated symptoms of PTSD in maternal rats. To induce predator stress in pregnant rats, rats were exposed to a hunting dog in an enclosed room. Exposure time was three 10‑min daily sessions separated by 1 h, starting at week 1 of pregnancy until delivery. Pregnant rats in the exercise group were forced to run on a treadmill for 30 min once a day, starting one week following pregnancy until delivery. Rats receiving predator stress during pregnancy exhibited PTSD anxiety‑like behaviors following delivery. Expression of 5‑hydroxytryptamine (5‑HT) and its synthesizing enzyme tryptophan hydroxylase (TPH) in the dorsal raphe was increased compared with unstressed rats. Expression of c‑Fos and neuronal nitric oxide synthases (nNOS) in the hypothalamus and locus coeruleus were higher in the rats receiving stress during pregnancy compared with unstressed rats. By contrast, treadmill exercise during pregnancy ameliorated anxiety‑like behaviors and reduced the expression of 5‑HT, TPH, c‑Fos and nNOS in the PTSD maternal rats. The results of the present study indicate that exercise during pregnancy is suitable for use as a therapeutic strategy to reduce anxiety‑related disorders, including PTSD.

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“…pCREB expression was selected because it is a marker of neuronal activation that is also strongly liked with neuroadaptation and synaptic plasticity [95–97], and our prior work has suggested that sucrose may act, at least in part, via inducing synaptic plasticity [67, 98]. Moreover, it should be noted that unstressed rodents have little pCREB-positive labeling in the PVN, BLA, and cortex [99–102]. This suggests that much of the pCREB labeling that is observed in the present work results from activation by the experimental interventions, with the key research question being whether access to sucrose drink vs. water differentially induces pCREB expression in the brain regions of interest after either novel or familiar exposure.…”

Section: Methodsmentioning

confidence: 99%

Activation of physiological stress responses by a natural reward: Novel vs. repeated sucrose intake

Egan

Ulrich‐Lai

2015

Physiology & Behavior

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Pharmacological rewards, such as drugs of abuse, evoke physiological stress responses, including increased heart rate and blood pressure, and activation of the hypothalamic-pituitary-adrenal (HPA) axis. It is not clear to what extent the natural reward of palatable foods elicits similar physiological responses. In order to address this question, HPA axis hormones, heart rate, blood pressure and brain pCREB immunolabeling were assessed following novel and repeated sucrose exposure. Briefly, adult, male rats with ad libitum food and water were given either a single (day 1) or repeated (twice-daily for 14 days) brief (up to 30 minutes) exposure to a second drink bottle containing 4 ml of 30% sucrose drink vs. water (as a control for bottle presentation). Sucrose-fed rats drank more than water-fed on all days of exposure, as expected. On day 1 of exposure, heart rate, blood pressure, plasma corticosterone, and locomotion were markedly increased by presentation of the second drink bottle regardless of drink type. After repeated exposure (day 14), these responses habituated to similar extents regardless of drink type and pCREB immunolabeling in the hypothalamic paraventricular nucleus (PVN) also did not vary with drink type, whereas basolateral amygdala pCREB was increased by sucrose intake. Taken together, these data suggest that while sucrose is highly palatable, physiological stress responses were evoked principally by the drink presentation itself (e.g., an unfamiliar intervention by the investigators), as opposed to the palatability of the offered drink.

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The effect of single or repeated restraint stress on several signal molecules in paraventricular nucleus, arcuate nucleus and locus coeruleus

Cited by 61 publications

References 74 publications

Differential Effects of Voluntary and Forced Exercise on Stress Responses after Traumatic Brain Injury

Differential Effects of Voluntary and Forced Exercise on Stress Responses after Traumatic Brain Injury

Treadmill exercise during pregnancy ameliorates post-traumatic stress disorder-induced anxiety-like responses in maternal rats

Activation of physiological stress responses by a natural reward: Novel vs. repeated sucrose intake

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