The Effect of Short-Toothed and Dalmatian Sage Extracts on Platelet Aggregation

Antolić, Andrea; Maleš, Željan; Tomičić, Maja; Bojić, Mirza

doi:10.17113/ftb.56.02.18.5474

Cited by 5 publications

(7 citation statements)

References 11 publications

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“…Furthermore, a recent study has reported that the antiinflammatory effect on COX-2 gene suppression could be attributed to the extracts of the coffee leaves, which contain CGA, CF, mangiferin, rutin, and other bioactive molecules [57]. Synergistically inhibitory effect of agonists-induced platelet aggregation, which is related to antioxidant activity and reported in extracts of plants (such as Salvia species), is possibly caused by the interaction of persisting phenolic compounds [58][59][60]. Taken together, our findings suggest the potential inhibition of platelet aggregation and COXs activities in the following order: Drip coffee > espresso coffee > boiled coffee > instant coffee > CF, CGA, suggesting that the degree of inhibition may not be influenced by the anti-oxidative compounds and caffeine present in the coffee extracts.…”

Section: Discussionmentioning

confidence: 99%

Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts (Coffea arabica)

et al. 2020

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Coffee is rich in caffeine (CF), chlorogenic acid (CGA) and phenolics. Differing types of coffee beverages and brewing procedures may result in differences in total phenolic contents (TPC) and biological activities. Inflammation and increases of platelet activation and aggregation can lead to thrombosis. We focused on determining the chemical composition, antioxidant activity and inhibitory effects on agonist-induced platelet aggregation and cyclooxygenase (COX) of coffee beverages in relation to their preparation method. We prepared instant coffee and brewed coffee beverages using drip, espresso, and boiling techniques. Coffee extracts were assayed for their CF and CGA contents using HPLC, TPC using colorimetry, platelet aggregation with an aggregometer, and COX activity using ELISA. The findings have shown all coffee extracts, except the decaffeinated types, contained nearly equal amounts of CF, CGA, and TPC. Inhibitory effects of coffee extracts on platelet aggregation differed depending on the activation pathways induced by different agonists. All espresso, drip and boiled coffee extracts caused dose dependent inhibition of platelet aggregation induced by ADP, collagen, epinephrine, and arachidonic acid (ARA). The most marked inhibition was seen at low doses of collagen or ARA. Espresso and drip extracts inhibited collagen-induced platelet aggregation more than purified caffeine or CGA. Espresso, boiled and drip coffee extracts were also a more potent inhibitors of COX-1 and COX-2 than purified caffeine or CGA. We conclude that inhibition of platelet aggregation and COX-1 and COX-2 may contribute to anti-platelet and anti-inflammatory effects of espresso and drip coffee extracts.

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Section: Discussionmentioning

confidence: 99%

Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts (Coffea arabica)

et al. 2020

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“…Salvia officinalis L. and Salvia brachyodon Vand. leaves extracts showed antiplatelet activity in concentrations of 21 nmol L -1 (40). Analysis of constituents did not show relation with neither flavonoid nor polyphenolic acids content.…”

Section: Mechanisms Of Antiplatelet Action Of Individual Flavonoids Hmentioning

confidence: 73%

Antithrombotic activity of flavonoids and polyphenols rich plant species

et al. 2019

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Cardiovascular diseases represent one of the most notable health problems of the modern civilization. Stroke and heart attack often lead to lethal outcome; essential problem underneath being thrombus formation. Prophylactic approaches include acetylsalicylic acid and clopidogrel therapy on the level of primary hemostasis, i.e., primary clot formation. In the last five years, in the USA, health care expenses related to cardiovascular diseases have increased 50 %, to over 350 billion dollars. Thus, application of plant species and medicinal plants rich in polyphenols in prevention of thrombus formation are of interest. This is supported by the fact that the number of publications on antiaggregatory effect of polyphenols has doubled in the last decade. In this review we focus on antiaggregatory effect of most abundant polyphenols – flavonoids, the effect of plant extracts rich in polyphenols (propolis, species Salvia sp., Calamintha nepeta L., Lavandula angustifolia Mill., Melissa officinalis L, Mentha x piperita L., Ocimum basilicum L., Origanum vulgare L., Rosmarinus officinalis L.) on platelet aggregation, association of chemical composition and antioxidant properties with the observed biological effect, and possible clinical significance of the published results.

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“…Furthermore, a recent study has reported that the anti-inflammatory effect on COX-2 gene suppression could be attributed to the extracts of the coffee leaves, which contain CGA, CF, mangiferin, rutin and other bioactive molecules [57]. Synergistically inhibitory effect of agonists-induced platelet aggregation, which is related to antioxidant activity and reported in extracts of plants (such as Salvia species), is possibly caused by the interaction of persisting phenolic compounds [58][59][60]. Taken together, our findings suggest the potential inhibition of platelet aggregation and COXs activities in the following order; drip coffee > espresso coffee > boiled coffee > instant coffee > CF, CGA, suggesting that the degree of inhibition may not be influenced by the anti-oxidative compounds and caffeine present in the coffee extracts.…”

Section: Discussionmentioning

confidence: 99%

Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts (<em>Coffea arabica</em>)

Hutachok¹,

Angkasith²,

Chumpun³

et al. 2020

Preprint

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Coffee is rich in caffeine (CF), chlorogenic acid (CGA) and phenolics. Differing types of coffee beverages and brewing procedures may result in differences in total phenolic contents (TPC) and biological activities. Inflammation and increases of platelet activation and aggregation can lead to thrombosis. We focused on determining the chemical composition, antioxidant activity and inhibitory effects on agonist-induced platelet aggregation and cyclooxygenase (COX) of coffee beverages in relation to their preparation method. We prepared instant coffee and brewed coffee beverages using drip, espresso and boiling techniques. Coffee extracts were assayed for their CF and CGA contents using HPLC, TPC using colourimetry, platelet aggregation with an aggregometer and COX activity using ELISA. The findings have shown all coffee extracts, except the decaffeinated types, contained nearly equal amounts of CF, CGA and TPC. Inhibitory effects of coffee extracts on platelet aggregation differed depending on the activation pathways induced by different agonists. All espresso, drip and boiled coffee extracts caused dose dependent inhibition of platelet aggregation induced by ADP, collagen, epinephrine, and arachidonic acid (ARA). The most marked inhibition was seen at low doses of collagen or ARA. Espresso and drip extracts inhibited collagen-induced platelet aggregation more than purified caffeine or CGA. Espresso, boiled and drip coffee extracts were also a more potent inhibitors of COX-1 and COX-2 than purified caffeine or CGA. We conclude that inhibition of platelet aggregation and COX-1 and COX-2 may contribute to anti-platelet and anti-inflammatory effects of espresso and drip coffee extracts.

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The Effect of Short-Toothed and Dalmatian Sage Extracts on Platelet Aggregation

Cited by 5 publications

References 11 publications

Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts (Coffea arabica)

Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts (Coffea arabica)

Antithrombotic activity of flavonoids and polyphenols rich plant species

Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts (<em>Coffea arabica</em>)

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