The effect of salts in aqueous media on the formation of the BSA corona on SiO2 nanoparticles

Givens, Brittany E.; Wilson, Elizabeth; Fiegel, Jennifer

doi:10.1016/j.colsurfb.2019.04.012

Cited by 22 publications

(15 citation statements)

References 70 publications

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“…[25][26][27][28][29][30] Generation of high-affinity discrete NP protein complexes for use at physiological conditions remains challenging. 31,32 Charged cationic gold NPs (AuNPs) can efficiently interact with negatively charged GFP ( pI = 5.9) in solutions of low ionic strength ( pH 7.4) to form discrete nanoscale complexes. These complexes have been effectively utilized as molecular agents for the detection of metastatic mammalian cells as well as disease-relevant levels of biomarker proteins in vitro.…”

Section: Introductionmentioning

confidence: 99%

High affinity protein surface binding through co-engineering of nanoparticles and proteins

et al. 2022

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Section: Introductionmentioning

confidence: 99%

High affinity protein surface binding through co-engineering of nanoparticles and proteins

et al. 2022

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“…This hydrophilic material is tunable in size, has a high surface area, and enables facile surface modifications [ 141 ]. Since silica appears to be required for bone formation [ 142 ], SiO 2 shows potential in bone repair applications if aggregation under physiological conditions [ 143 ] and poor mechanical properties can be overcome.…”

Section: Coating Materials Selectionmentioning

confidence: 99%

Addressing the Needs of the Rapidly Aging Society through the Development of Multifunctional Bioactive Coatings for Orthopedic Applications

Mastnak

Maver

Finšgar

2022

IJMS

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The unprecedented aging of the world’s population will boost the need for orthopedic implants and expose their current limitations to a greater extent due to the medical complexity of elderly patients and longer indwelling times of the implanted materials. Biocompatible metals with multifunctional bioactive coatings promise to provide the means for the controlled and tailorable release of different medications for patient-specific treatment while prolonging the material’s lifespan and thus improving the surgical outcome. The objective of this work is to provide a review of several groups of biocompatible materials that might be utilized as constituents for the development of multifunctional bioactive coatings on metal materials with a focus on antimicrobial, pain-relieving, and anticoagulant properties. Moreover, the review presents a summary of medications used in clinical settings, the disadvantages of the commercially available products, and insight into the latest development strategies. For a more successful translation of such research into clinical practice, extensive knowledge of the chemical interactions between the components and a detailed understanding of the properties and mechanisms of biological matter are required. Moreover, the cost-efficiency of the surface treatment should be considered in the development process.

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“…Nanoparticles agglomerate in a solution depending on the solution's ionic strength and the nanoparticles' superficial charge [54]. Because of this, determining the size of the nanoparticles in suspension is important.…”

Section: Nanoparticle Characterizationmentioning

confidence: 99%

Palladium Nanoparticles Functionalized with PVP-Quercetin Inhibits Cell Proliferation and Activates Apoptosis in Colorectal Cancer Cells

et al. 2021

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Nanotechnology is focused on the development and application of novel nanomaterials with particular physicochemical properties. Palladium nanoparticles (PdNPs) have been used as antimicrobials, antifungals, and photochemicals and for catalytic activity in dye reduction. In the present investigation, we developed and characterized PdNPs as a carrier of quercetin and initiated a study of its effects in colorectal cancer cells. PdNPs were first functionalized with polyvinylpyrrolidone (PVP) and then coupled to quercetin (PdNPs-PVP-Q). Our results showed that quercetin was efficiently incorporated to PdNPs-PVP, as demonstrated using UV/Vis and FT-IR spectroscopy. Using transmission electron microscopy, we demonstrated a reduction in size from 3–14.47 nm of PdNPs alone to 1.8–7.4 nm of PdNPs-PVP and to 2.12–3.14 of PdNPs-PVP-Q, indicating an increase in superficial area in functionalized PdNPs-Q. Moreover, hydrodynamic size studies using dynamic light scattering showed a reduction in size from 2120.33 nm ± 112.53 with PdNPs alone to 129.96 nm ± 6.23 for PdNPs-PVP-Q, suggesting a major reactivity when quercetin is coupled to nanoparticles. X-ray diffraction assays show that the addition of PVP or quercetin to PdNPs does not influence the crystallinity state. Catalytic activity assays of PdNPs-PVP-Q evidenced the chemical reduction of 4-nitrophenol, methyl orange, and methyl blue, thus confirming an electron acceptor capacity of nanoparticles. Finally, biological activity studies using MTT assays showed a significant inhibition (p < 0.05) of cell proliferation of HCT-15 colorectal cancer cells exposed to PdNPs-PVP-Q in comparison to untreated cells. Moreover, treatment with PdNPs-PVP-Q resulted in the apoptosis activation of HCT-15 cells. In conclusion, here we show for the first time the development of PdNPs-PVP-Q and evidence its biological activities through the inhibition of cell proliferation and apoptosis activation in colorectal cancer cells in vitro.

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The effect of salts in aqueous media on the formation of the BSA corona on SiO2 nanoparticles

Cited by 22 publications

References 70 publications

High affinity protein surface binding through co-engineering of nanoparticles and proteins

High affinity protein surface binding through co-engineering of nanoparticles and proteins

Addressing the Needs of the Rapidly Aging Society through the Development of Multifunctional Bioactive Coatings for Orthopedic Applications

Palladium Nanoparticles Functionalized with PVP-Quercetin Inhibits Cell Proliferation and Activates Apoptosis in Colorectal Cancer Cells

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