The effect of resveratrol supplementation on serum levels of asymmetric de‐methyl‐arginine and paraoxonase 1 activity in patients with type 2 diabetes: A randomized, double‐blind controlled trial

Tabatabaie, Mahtab; Abdollahi, Shima; Salehi‐Abargouei, Amin; Clark, Cain C. T.; Karimi-Nazari, Elham; Fallahzadeh, Hossein; Rahmanian, Masoud; Mozaffari‐Khosravi, Hassan

doi:10.1002/ptr.6655

Cited by 19 publications

(18 citation statements)

References 71 publications

(79 reference statements)

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“…PON1 is an esterase that is generated in the liver, and it is associated with the HDL-enzyme that hydrolyzes oxidized LDL-cholesterol. It has atheroprotective capabilities [8]. The activity of PON1 is decreased in diabetes mellitus, metabolic syndrome, hypercholesterolemia, and chronic renal failure [9].…”

Section: Redox Balance In Obesitymentioning

confidence: 99%

Oxidative Stress, Plant Natural Antioxidants, and Obesity

Pérez-Torres

Castrejón-Téllez

Soto

et al. 2021

IJMS

211

123

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Oxidative stress is important in the pathophysiology of obesity, altering regulatory factors of mitochondrial activity, modifying the concentration of inflammation mediators associated with a large number and size of adipocytes, promoting lipogenesis, stimulating differentiation of preadipocytes to mature adipocytes, and regulating the energy balance in hypothalamic neurons that control appetite. This review discusses the participation of oxidative stress in obesity and the important groups of compounds found in plants with antioxidant properties, which include (a) polyphenols such as phenolic acids, stilbenes, flavonoids (flavonols, flavanols, anthocyanins, flavanones, flavones, flavanonols, and isoflavones), and curcuminoids (b) carotenoids, (c) capsaicinoids and casinoids, (d) isothiocyanates, (e) catechins, and (f) vitamins. Examples are analyzed, such as resveratrol, quercetin, curcumin, ferulic acid, phloretin, green tea, Hibiscus Sabdariffa, and garlic. The antioxidant activities of these compounds depend on their activities as reactive oxygen species (ROS) scavengers and on their capacity to prevent the activation of NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells), and reduce the expression of target genes, including those participating in inflammation. We conclude that natural compounds have therapeutic potential for diseases mediated by oxidative stress, particularly obesity. Controlled and well-designed clinical trials are still necessary to better know the effects of these compounds.

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Section: Redox Balance In Obesitymentioning

confidence: 99%

Oxidative Stress, Plant Natural Antioxidants, and Obesity

Pérez-Torres

Castrejón-Téllez

Soto

et al. 2021

IJMS

211

123

View full text Add to dashboard Cite

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“…In the present paper, we summarize the evidence on HDL functionality (CEC, CETP activity, and its antioxidant capacity by PON1 activity) as well as its expression and relationship with functional foods (extra virgin olive oil [ 27 , 81 , 83 , 84 , 85 ], whole grains [ 81 ], nuts [ 27 , 81 , 86 , 87 ], legumes [ 81 , 88 ], fresh fish [ 81 , 89 , 90 ], red wine [ 91 ]), fruits and vegetables [ 92 , 93 , 94 , 95 ], ginger [ 80 ], green tea [ 91 , 96 ], cocoa [ 91 , 97 ], and bioactive compounds as curcumin [ 79 , 80 ], resveratrol [ 78 , 98 ], and quercetin [ 75 , 76 , 99 ].…”

Section: Dietary Compounds and Their Effects On The Modulation Of Hdl-c Functionalitymentioning

confidence: 99%

“…Seventy-one patients with type 2 diabetes were randomized to intake 2000 mg of resveratrol or placebo for 8 weeks, and PON1 activity was evaluated in blood. After this period of intervention, PON1 increased its activity significantly compared to the placebo group [ 98 ]. Data are not shown in the tables because the study did not evaluate the food intake.…”

Section: Dietary Compounds and Their Effects On The Modulation Of Hdl-c Functionalitymentioning

confidence: 99%

Functional Food and Bioactive Compounds on the Modulation of the Functionality of HDL-C: A Narrative Review

et al. 2021

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Cardiovascular diseases (CVD) remain a serious public health problem and are the primary cause of death worldwide. High-density lipoprotein cholesterol (HDL-C) has been identified as one of the most important molecules in the prevention of CVD due to its multiple anti-inflammatories, anti-atherogenic, and antioxidant properties. Currently, it has been observed that maintaining healthy levels of HDL-C does not seem to be sufficient if the functionality of this particle is not adequate. Modifications in the structure and composition of HDL-C lead to a pro-inflammatory, pro-oxidant, and dysfunctional version of the molecule. Various assays have evaluated some HDL-C functions on risk populations, but they were not the main objective in some of these. Functional foods and dietary compounds such as extra virgin olive oil, nuts, whole grains, legumes, fresh fish, quercetin, curcumin, ginger, resveratrol, and other polyphenols could increase HDL functionality by improving the cholesterol efflux capacity (CEC), paraoxonase 1 (PON1), and cholesteryl ester transfer protein (CETP) activity. Nevertheless, additional rigorous research basic and applied is required in order to better understand the association between diet and HDL functionality. This will enable the development of nutritional precision management guidelines for healthy HDL to reduce cardiovascular risk in adults. The aim of the study was to increase the understanding of dietary compounds (functional foods and bioactive components) on the functionality of HDL.

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“…A total of 616 articles were retrieved through the database: 590 articles were excluded by reading titles and abstracts, and eight articles were excluded by reading the full text. Finally, 18 articles met the inclusion criteria [15][16][17][18][19][24][25][26][27][28][29][30][31][32][33][34][35][36] (Figure 1). ree studies are by Bo et al [16,29,30], two studies are by Imamura et al [17], and two studies are by Abdollahi et al [33,34], and they were merged.…”

Section: Results Of the Search And Description Of Included Trialsmentioning

confidence: 99%

“…Finally, 18 articles met the inclusion criteria [15][16][17][18][19][24][25][26][27][28][29][30][31][32][33][34][35][36] (Figure 1). ree studies are by Bo et al [16,29,30], two studies are by Imamura et al [17], and two studies are by Abdollahi et al [33,34], and they were merged. Study characteristics are presented in Table 1.…”

Section: Results Of the Search And Description Of Included Trialsmentioning

confidence: 99%

Efficacy and Safety of Resveratrol Supplements on Blood Lipid and Blood Glucose Control in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zhang

Liu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Diabetes is a major public health concern. Resveratrol has shown great beneficial effects on hyperglycemia and insulin resistance and as an antioxidant. Methods. We searched the Chinese and English databases (such as CNKI, PubMed, and Embase) and extracted data from randomized controlled trials (RCTs). Then, RevMan 5.3 was used for bias risk assessment and meta-analysis. The primary outcome indicators include insulin-resistance-related indicators and blood-lipid-related indicators. This systematic review and meta-analysis was registered in PROSPERO (CRD42018089521). Results. Fifteen RCTs involving 896 patients were included. For insulin-resistance-related indicators, the summary results showed that, compared with the control group, homeostasis model assessment for insulin resistance (HOMA-IR) in the resveratrol group is lower (WMD: −0.99; 95% CI −1.61, −0.38; P = 0.002 ). For blood-lipid-related indicators, the total cholesterol (TC) and triglyceride (TG) in the resveratrol group is of no statistical significance (for TC, WMD: −7.11; 95% CI −16.28, 2.06; P = 0.13 ; for TG, WMD: −2.15; 95% CI −5.52, 1.22; P = 0.21 ). For adverse events, the summary results showed that there was no statistical difference in the incidence of adverse events between the resveratrol and control groups (WMD: 2; 95% CI 0.44, 9.03; P = 0.37 ). Conclusion. Based on the current evidence, resveratrol may improve insulin resistance, lower fasting blood glucose and insulin levels, and improve oxidative stress in patients with type 2 diabetes mellitus.

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The effect of resveratrol supplementation on serum levels of asymmetric de‐methyl‐arginine and paraoxonase 1 activity in patients with type 2 diabetes: A randomized, double‐blind controlled trial

Abstract: The effect of resveratrol supplementation on serum levels of asymmetric de-methyl-arginine and paraoxonase 1 activity in patients with type 2 diabetes: A randomized, double-blind controlled trial',

Cited by 19 publications

References 71 publications

Oxidative Stress, Plant Natural Antioxidants, and Obesity

Oxidative Stress, Plant Natural Antioxidants, and Obesity

Functional Food and Bioactive Compounds on the Modulation of the Functionality of HDL-C: A Narrative Review

Efficacy and Safety of Resveratrol Supplements on Blood Lipid and Blood Glucose Control in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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