The effect of reserpine, a modulator of multidrug efflux pumps, on the in vitro activity of tetracycline against clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) possessing the tet(K) determinant

The Combination of Catechin and Epicatechin Gallate from Fructus Crataegi Potentiates β-Lactam Antibiotics Against Methicillin-Resistant Staphylococcus aureus (MRSA) in Vitro and in Vivo

“…The results showed that reserpine as a positive control could downregulate mRNA expressions of norA and norC not abcA , which was in accordance with previous reports [23,24]. C or ECg alone did not influence efflux pump gene expression, but C in combination with ECg could downregulate mRNA expressions of norA , norC and abcA among eight efflux pumps of MRSA (Figure 3), thus suggesting that increased daunorubicin accumulation was related to the inhibition of three efflux pumps’ gene expressions.…”

P-type ATPase zinc transporter Rv3270 of Mycobacterium tuberculosis enhances multi-drug efflux activity

“…Furthermore, to confirm the role of Rv3270 in influencing multi-drug efflux and biofilm formation, an efflux pump blocker, reserpine, was used. As reported previously, reserpine directly interacts with the efflux pump proteins by acting as a promising inhibitor [52, 53]. Reserpine not only had an inhibitory effect on antibiotic efflux but also affects the biofilm-forming ability of the cells harbouring rv3270 .…”

ChemInform Abstract: Structure and Antibacterial Activity of Brominated Diterpenes from the Red Alga Sphaerococcus coronopifolius.

“…The strong NOE correlations of Me(17)/H a ÀC(10), Me(17)/H a ÀC(6), Me(20)/H a ÀC(6), HÀC(14)/Me (20), and HÀC(14)/Me(17) determined the configuration at C(4), C(8), and C (14). The NOE correlations of Me(16)/HÀC(1) and Me(16)/Me(21) confirmed the equatorial configuration of Me (16). The large couplingconstant values of the H-atom pairs H a ÀC(6)/H b ÀC (7), HÀC(9)/H a ÀC(10), and HÀC(13)/HÀC (14) supported their trans-diaxial configuration, establishing the chair conformation of the rings B and C. In view of the above-mentioned data, metabolite 1 was assigned as (1S*)-1-methoxybromotetrasphaerol.…”