The effect of recombinant human TSH on 123I thyroid uptake after intravenous iodide contrast agent

Abstract

It was shown that a single dose of 0.1 mg of rhTSH, given 96 h after the exposure to computed tomography iodinated contrast media, enhances the RAIU in nine euthyroid patients 4 h after 123I administration. These results indicate that rhTSH could be useful for avoiding delay in the treatment of patients with 131I.

Proteomic Analysis of Iodinated Contrast Agent-Induced Perturbation of Thyroid Iodide Uptake

“…The effect of ICM on TSH-induced iodide uptake by the thyroid is not well-documented. A clinical study reported that the inhibition of iodide uptake by the thyroid could be reversed by intramuscular administration of recombinant human TSH [38]. However, the ICM stunning reported in this study was relatively low and a large heterogeneity was observed in the nine patients of the cohort [38].…”

“…A clinical study reported that the inhibition of iodide uptake by the thyroid could be reversed by intramuscular administration of recombinant human TSH [38]. However, the ICM stunning reported in this study was relatively low and a large heterogeneity was observed in the nine patients of the cohort [38]. In another study, the anecdotic case of a patient with differentiated thyroid carcinoma and who had previously received ICM was reported.…”

“…Guidelines recommend a delay in the radioactive-iodide treatment of patients with differentiated thyroid carcinoma who have been injected previously with ICM [9,[11][12][13]. As upon ICM injection urinary iodide levels are elevated for several weeks [19][20][21][22] and as free-iodide was considered to be the cause of thyroid stunning by ICM [9,38], urinary iodide content has been proposed as a surrogate marker of recovery of iodide uptake by the thyroid [12,[19][20][21][22]. In the light of our results, the relevance of the measurement of urinary iodide to predict the recovery of iodide uptake by the thyroid is questionable.…”