The effect of prophylactic migraine treatment on arterial stiffness

Doğan, Ali; Örsçelik, Özcan; Kocyigit, Merva; Elçik, Deniz; Baran, Oğuzhan; Cerit, Nebi; İnanç, Mehmet Tuğrul; Kalay, Nihat; İsmailoğulları, Sevda; Saka, Tolga; Özdoğru, İbrahіm; Oğuzhan, Abdurrahman; Eryol, Namık Kemal

doi:10.3109/08037051.2015.1030902

Cited by 8 publications

(18 citation statements)

References 48 publications

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“…24 Hence, we cannot rule out the interference of specified treatments in PWV measurements or other parameters, as we did not include these data in the analysis. One study showed that prophylactic migraine drugs improve PWV.…”

Section: Discussionmentioning

confidence: 99%

“…One study showed that prophylactic migraine drugs improve PWV. 24 Hence, we cannot rule out the interference of specified treatments in PWV measurements or other parameters, as we did not include these data in the analysis.…”

Section: Discussionmentioning

confidence: 99%

“…10,13 Any sign of carotid artery damage is an independent predictor of overall vascular or specified cerebrovascular events. 6,18 However, the relationship between migraine and arterial stiffening [20][21][22][23][24] or carotid artery disease 20,23-35 is controversial. 14,17 Moreover, PWV measurement is the most appropriate method to assess arterial stiffness, 18,19 and the identification of increased PWV improves risk discrimination of the first cardiovascular event.…”

Section: Introductionmentioning

confidence: 99%

“…14,17 Moreover, PWV measurement is the most appropriate method to assess arterial stiffness, 18,19 and the identification of increased PWV improves risk discrimination of the first cardiovascular event. 6,18 However, the relationship between migraine and arterial stiffening [20][21][22][23][24] or carotid artery disease 20,[23][24][25][26][27][28][29][30][31][32][33][34][35] is controversial. Hence, this study aimed to evaluate the association between migraine and the markers of vascular damage, namely carotid thickening, carotid plaques, and arterial stiffening, in middle-aged women.…”

Section: Introductionmentioning

confidence: 99%

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Migraine and Markers of Carotid Atherosclerosis in Middle‐Aged Women: A Cross‐Sectional Study

et al. 2018

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Objective This study evaluated the association between migraine and the markers of carotid artery disease. Background Migraine increases the risk of cardiovascular events, but its relationship with vascular dysfunction is unclear. Methods In this cross‐sectional study, middle‐aged women with no known cardiovascular diseases underwent clinical, neurological, and laboratory evaluations; pulse wave velocity (PWV) assessment; and carotid artery ultrasonography. We divided the participants based on the presence of migraine and, further, based on the type of migraine. Associations between migraine and carotid thickening (intima‐media thickness >0.9 mm), carotid plaques, or arterial stiffening (PWV >10 m/s) were evaluated using a multiple regression analysis. Results The study comprised 112/277 (40%) women with migraine, of whom 46/277 (17%) reported having an aura. Compared to the non‐migraineurs, the migraine with aura group had an increased risk of diffuse carotid thickening (3/46 [6.8%] vs 2/165 [1.3%], adjusted OR = 7.12, 95% CI 1.05–48.49). Migraine without aura was associated with a low risk of carotid plaques (3/66 [4.7%] vs 26/165 [16.7%], adjusted OR = 0.28, 95% CI 0.08–0.99) and arterial stiffening (21/66 [34.4%] vs 82/165 [51.2%], adjusted OR = 0.39, 95% CI 0.19–0.79). There were no correlations between migraine characteristics and arterial stiffness or carotid thickness measurements. Conclusion Migraine with aura is associated with an increased risk of carotid thickening, and migraine without aura is associated with a low risk of carotid plaques and arterial stiffening.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Migraine and Markers of Carotid Atherosclerosis in Middle‐Aged Women: A Cross‐Sectional Study

et al. 2018

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“…According to that study it can be said that migraine patients with aura have a higher cardiovascular risk. Dogan et al compared migraine patients without cardiovascular risk factors with a control group and found higher CFPWV in the migraine patients 30 . In the current study, no difference was determined between patients with and without aura.…”

Section: Discussionmentioning

confidence: 99%

Premenapozal migren hastalarında aort sertliği parametrelerinin değerlendirilmesi

Güntürk

Dogan

Topuz

2020

Cukurova Medical Journal

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Öz Purpose: Migraine is an episodic primary headache disorder, which affects approximately 10% of the adult population, predominantly females. Based on the changes detected in migraine and previous findings, arterial stiffness can be considered to be an important contributor to vascular events in patients with migraine. The aim of this study was to investigate the associations between atherosclerosis and migraine through the evaluation of aortic stiffness in premenopausal migraine patients. Materials and Methods: The study included 68 female patients with migraine, and a control group of 39 healthy females. To reveal the association between migraine and arterial stiffness, echocardiography was applied and aortic stiffness was evaluated. Blood pressure measurements, basic biochemical tests and the 12 derivation-ECG recordings of each patient were taken simultaneously. Results: Basic echocardiographic findings were similar in patients and the control group. Systolic and diastolic diameters of the aorta, and the change in aortic diameter were also similar in both groups. Aortic distensibility, aortic strain and beta indices were also similar in both groups. No significant differences were determined between patients with and without aura migraine and the control group in respect of systolic blood pressure, diastolic blood pressure and pulse pressure. Conclusion: As a marker of atherosclerosis, the aortic stiffness parameters didn't differ between migraine and control group.

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Adjuvant Migraine Medications in the Treatment of Sudden Sensorineural Hearing Loss

et al. 2020

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Objectives/Hypothesis: To examine the hearing outcomes of patients with sudden sensorineural hearing loss (SSNHL) treated with oral and intratympanic (IT) steroid only or a combination of steroid and migraine treatment. Our hypothesis was that adjuvant migraine medications may improve outcomes in SSNHL. Methods: A retrospective chart review at a tertiary otology center was conducted to identify patients with SSNHL who received oral steroid and IT dexamethasone injection(s) with or without migraine medications (a combination of nortriptyline and topiramate). Results: A total of 47 patients received oral steroid and IT dexamethasone injection(s) only, and 46 patients received oral steroid and IT dexamethasone injection(s) as well as migraine lifestyle changes plus a combination of nortriptyline and topiramate. There were no significant differences in demographics and baseline audiometric data between the two groups. Both groups demonstrated improvements in pure tone average (PTA) and hearing thresholds at 250 Hz and 8000 Hz posttreatment. However, compared to steroid-only group, the adjuvant migraine medications group had significantly greater improvements in hearing thresholds at the lower frequencies (250 Hz, 500 Hz, 1000 Hz). Patients in the latter cohort also had greater improvement in PTA (P = .01) and received fewer IT injections (P = .04) PTA improvement of ≥ 10 dB was observed in 36 patients (78%) in the adjuvant migraine medications group and 22 patients (46%) in the control group (P < .001). Conclusion: In multimodal treatment of SSNHL, supplementing oral and IT steroid with migraine medications may result in greater improvements in lower frequency hearing thresholds and PTA. Furthermore, adjuvant migraine treatment can lead to decrease in number of IT injections, thus reducing procedure-related risks and complications.

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The effect of prophylactic migraine treatment on arterial stiffness

Cited by 8 publications

References 48 publications

Migraine and Markers of Carotid Atherosclerosis in Middle‐Aged Women: A Cross‐Sectional Study

Migraine and Markers of Carotid Atherosclerosis in Middle‐Aged Women: A Cross‐Sectional Study

Premenapozal migren hastalarında aort sertliği parametrelerinin değerlendirilmesi

Adjuvant Migraine Medications in the Treatment of Sudden Sensorineural Hearing Loss

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