Arch Pediatr Adolesc Med
 1988
DOI: 10.1001/archpedi.1988.02150010072025
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The Effect of Prophylactic Acetaminophen Administration on Reactions to DTP Vaccination

Karen Lewis
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Cited by 72 publications

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“…The recommendation was based on a study where two doses of acetaminophen were used. A positive effect of acetaminophen was also found in another study where five doses of the drug were used (5). It is quite possible that multiple doses of acetaminophen are effective since antipyretic drugs are effective in reducing fever already present (6).…”
Section: Discussionmentioning
confidence: 75%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The recommendation was based on a study where two doses of acetaminophen were used. A positive effect of acetaminophen was also found in another study where five doses of the drug were used (5). It is quite possible that multiple doses of acetaminophen are effective since antipyretic drugs are effective in reducing fever already present (6).…”
Section: Discussionmentioning
confidence: 75%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The beneficial effect of prophylactic paracetamol on the incidence of fever and common adverse reactions following pediatric immunization has already been demonstrated in clinical trials performed in the 1980s. 4,5 Results from a recent trial in the US also found a significantly lower frequency of temperature ≥38 °C among infants aged between 24 wk and 10 mo given prophylactic paracetamol (13% in the prophylactic paracetamol group vs. 25% in the control group) following routinely recommended vaccinations. 6 In addition, a trial of paracetamol prophylaxis in infants receiving 10-valent pneumococcal non-typeable Hemophilus influenzae protein D-conjugate vaccine (PHiD-CV) co-administered with a combination DTaP-HBV-IPV-Hib vaccine and oral human rotavirus vaccine reported that rectal temperature ≥38 °C within 4 d post-vaccination was significantly less frequent in the group with paracetamol prophylaxis (42%) than the no paracetamol group (66%).…”
Section: Discussionmentioning
confidence: 98%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“……”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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