The Effect of Platelet-Rich Plasma on Type I Collagen Production, VEGF Expression, and Neovascularization after Femoral Bone Implants: A Study on Rat Models

Rahman, Safrizal; Sutedja, Endang; Ayu, Onarisa; Amirsyah, Mirnasari

doi:10.2147/orr.s359844

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…This is consistent with this case, as our patient reported decreased pain every visit after his injection. Finally, one last mechanism worth mentioning regarding the healing properties of platelet releasate is the stimulation of collagen production from fibroblasts, which can promote the formation of new, stronger tendon tissue [ 11 ]. Platelet releasate contains fibroblast growth factor (FGF), which is responsible for extracellular matrix and collagen synthesis, which is important for the regeneration of tissue.…”

Section: Discussionmentioning

confidence: 99%

Platelet Releasate and Extracorporeal Shock Wave Therapy (ESWT) for Treatment of a Partial Supraspinatus Tear in an Adolescent Baseball Player

Alkhabbaz,

Bibi,

Marikh

et al. 2024

Cureus

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Supraspinatus tears are a common injury, particularly among athletes who engage in sports that include repetitive overhead motions, such as baseball players. Standard conservative therapies include rest and activity modification, physical therapy, non-steroidal anti-inflammatory drugs (NSAIDs), cold/heat therapy, and corticosteroid injections. Ongoing research and anecdotal evidence support using platelet-rich plasma (PRP) for supraspinatus/rotator cuff tears. Platelet releasate is obtained from PRP via the activation of platelets, subsequently releasing bioactive substances. Activation can be achieved through various methods, some of which include the addition of calcium chloride, thrombin, or exposure to low-level lasers. Platelet releasate has the potential to assist in the healing of tears by releasing growth factors that facilitate muscle and tendon repair. This case presentation discusses the outcomes of platelet releasate paired with extracorporeal shock wave therapy (ESWT) for the treatment of a partial-thickness supraspinatus tear in an 18-year-old male baseball athlete. After exploring conservative treatment options, the patient opted for a single platelet releasate injection along with a four-part series with ESWT. Four weeks post-procedure, the patient reported a 25% improvement. He was able to fully return to play for the entire baseball season. Although the effectiveness of platelet releasate is still a topic of debate and further investigation, this case demonstrates how platelet releasate shows promising results in accelerating the treatment recovery for a partial supraspinatus tear. Further investigation and research could support the benefit of this procedure for accelerated recovery of injuries compared to PRP.

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Section: Discussionmentioning

confidence: 99%

Platelet Releasate and Extracorporeal Shock Wave Therapy (ESWT) for Treatment of a Partial Supraspinatus Tear in an Adolescent Baseball Player

Alkhabbaz,

Bibi,

Marikh

et al. 2024

Cureus

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“…While studies have suggested efficacy of PRP and CBT in the treatment of chondral injuries [2, 8, 11, 14], less evidence is available investigating their effects on the healing of acetabular labral repairs. In theory, the increased neovascularization and collagen production associated with PRP usage could stimulate the healing process after a labral repair [16, 42].…”

Section: Discussionmentioning

confidence: 99%

“…In an effort to improve patient outcomes, orthobiologics such as hyaluronic acid (HA), platelet‐rich plasma (PRP), and cell‐based therapies (CBT) have been proposed as an adjunct treatment modality for FAIS [24, 48]. While the evidence regarding their mechanism of action continues to evolve, proposed benefits of these various orthobiologics for musculoskeletal disorders include pain relief, inhibition of the intra‐articular inflammatory cascade, and stimulation of soft‐tissue healing [4, 5, 9, 11, 12, 16, 21, 25, 42].…”

Section: Introductionmentioning

confidence: 99%

Orthobiologics as an adjunct in treatment of femoroacetabular impingement syndrome: cell‐based therapies facilitate improved postoperative outcomes in the setting of acetabular chondral lesions—a systematic review

George,

Curley,

Saeed

et al. 2023

Knee surg. sports traumatol. arthrosc.

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Purpose To evaluate studies utilizing orthobiologics in the management of femoroacetabular impingement syndrome (FAIS) to (1) assess the indications for usage, and (2) analyze patient-reported outcome measures (PROM) following treatment. It was hypothesized that orthobiologics would (1) be utilized for symptomatic FAIS in the setting of labral or chondral pathology, and (2) improve PROM at most recent follow-up. Methods The Pubmed, Ovid Medline, Cochrane, and Web of Science databases were searched for clinical studies evaluating orthobiologics [hyaluronic acid (HA), platelet-rich plasma (PRP), or cell-based therapy (CBT) for treatment of FAIS. Exclusion criteria included orthobiologics used in conjunction with cartilage transfer or scaffolding procedures and a primary indication other than FAIS. Data collection included patient demographics, indications, and baseline and most recent PROM.Results Eleven studies (one level I, four level II, four level III, and two level IV evidence) met inclusion criteria, consisting of 440 patients with mean ages ranging from 32.8 to 47 years. All 11 studies demonstrated an improvement in PROM from baseline to most-recent follow-up. Four studies administered PRP either intraoperatively or the day after surgery as an adjunct to labral repair. CBT was used intraoperatively in the setting of acetabular chondral lesions (three studies) and labral repair (one study). When comparing to a control group at most recent follow-up, three PRP cohorts demonstrated similar PROM (n.s.), while one PRP group exhibited worse visual analog pain scores (2.5 vs. 3.4, p = 0.005) and modified Harris Hip Scores (mHHS) (82.6 vs. 78.7, p = 0.049). The four CBT studies reported favorable results compared to a control group, with a significantly higher mHHS at most recent follow-up or mean improvement from baseline in Hip Outcome Score-Activities of Daily Living (p < 0.05). Three studies reported on HA, which was utilized exclusively in the nonoperative setting. Conclusions Intraoperative PRP and CBT have been commonly reported in the setting of hip arthroscopy for labral repairs and acetabular chondral lesions, respectively. The CBT cohorts demonstrated more favorable PROM at most recent follow-up when compared to a control group, though these results should be interpreted with caution due to heterogeneity of orthobiologic preparations. Level of evidence IV.

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The Effect of Mineralized Plasmatic Matrix and Chitosan on the Healing of Critical-Sized Mandibular Bone Defects in a Rabbit Model

et al. 2022

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Background: In maxillofacial surgery, critical size mandibular defects remain a challenging issue. There have been numerous attempts to improve mandibular defect healing. Recently, bone tissue engineering has provided many benefits in improving bone healing. Herein, we tried to investigate the effect of Mineralized plasmatic matrix (MPM) and Chitosan to enhance tissue healing and regeneration in mandibular bone defect. Methods: A mandibular bone defect of critical size was created in 45 New Zealand rabbits. There were three groups of rabbits: the MPM group, the Chitosan group, and the control group. Radiographical, histological, and immune histochemical evaluations were performed at 4, 8, and 12 post-operative weeks. Results: The MPM group demonstrated the highest degree of bone formation with uniform radio-opacity nearly like that of adjacent healthy parent tissue. While in the chitosan group, most of the defect area was filled with radio-opaque bone with persistent small radiolucent areas. The control group showed less bone formation than the MPM and chitosan group, with more radiolucent areas. Sections stained with (H&E) demonstrated an increase in osseous tissue formation in both the MPM and chitosan groups. Staining with Masson’s trichrome revealed an increase in fibrous connective tissue proliferation in both the MPM and chitosan groups. In both the MPM and chitosan groups, nuclear factor kappa p65 was downregulated, and matrix metalloproteinase-9 was upregulated. Conclusion: According to the current study, MPM and Chitosan may have beneficial effects on the healing of critical-sized mandibular bone defects.

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The Effect of Platelet-Rich Plasma on Type I Collagen Production, VEGF Expression, and Neovascularization after Femoral Bone Implants: A Study on Rat Models

Cited by 4 publications

References 34 publications

Platelet Releasate and Extracorporeal Shock Wave Therapy (ESWT) for Treatment of a Partial Supraspinatus Tear in an Adolescent Baseball Player

Platelet Releasate and Extracorporeal Shock Wave Therapy (ESWT) for Treatment of a Partial Supraspinatus Tear in an Adolescent Baseball Player

Orthobiologics as an adjunct in treatment of femoroacetabular impingement syndrome: cell‐based therapies facilitate improved postoperative outcomes in the setting of acetabular chondral lesions—a systematic review

The Effect of Mineralized Plasmatic Matrix and Chitosan on the Healing of Critical-Sized Mandibular Bone Defects in a Rabbit Model

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