The effect of platelet-rich plasma on reducing blood loss after total knee arthroplasty

Ma, Jinhui; Sun, Jiale; Guo, Wanshou; Li, Zirong; Wang, Bailiang; Wang, Weiguo

doi:10.1097/md.0000000000007262

Cited by 17 publications

(16 citation statements)

References 27 publications

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“…However, there is low to very low quality evidence regarding the effectiveness of most of these topical agents, except for cadexomer iodine . Autologous platelet‐rich plasma (PRP) has been used for 30 years in a variety of surgical situations, including blood loss reduction and promotion of tissue regeneration . Although individual small‐scale studies reported an effective use of PRP in VLU management, strong evidence for its effectiveness from high‐quality randomized controlled trials (RCTs) is lacking.…”

Section: Introductionmentioning

confidence: 99%

Adjuvant therapies in venous leg ulcer management: A scoping review

Team

Chandler

Weller

2019

Wound Repair Regeneration

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Compression therapy is the current evidence-based approach to manage venous leg ulcers (VLU); however, adherence is a major barrier to successful treatment. Combination approaches may relieve the burden of treatment by shortening the time to ulcer healing. This scoping review conducted by Australian researchers aimed to establish the evidence of effectiveness of various adjuvant methods on wound healing and recurrence. Randomized Controlled Trials (RCTs), and Systematic Reviews (SR) and Meta-Analyses (MA) on VLU management approaches published from January 2015 to December 2018 were included in this review. The articles included in the scoping review were grouped according to the management approaches, including (1) pharmaceutical interventions, (2) surgical interventions, (3) topical agents, (4) the use of devices, and (5) other, such as physiotherapy and psychological interventions. Results of this scoping review indicate that there is a limited high-quality evidence of effectiveness in most adjuvant therapies on wound healing and recurrence. Given the lowquality evidence observed in this scoping review for adjuvant treatments, the implication for practice is that current management guidelines be followed. Further rigorous studies have the potential to produce better quality evidence. Quality of evidence can be improved by ensuring large sample sizes of a single etiology wounds, standardizing reporting outcomes, and maintaining detailed and evidence-based protocols in physiological or psychological interventions.

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Section: Introductionmentioning

confidence: 99%

Adjuvant therapies in venous leg ulcer management: A scoping review

Team

Chandler

Weller

2019

Wound Repair Regeneration

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“…In the first stage of screening titles and abstracts, 79 references were selected. Full texts were scrutinised against the inclusion and exclusion criteria, with a final inclusion of 29 SRs (Figure ) . Reasons for exclusion of studies at the second stage are presented by topic and clinical indication in Files …”

Section: Resultsmentioning

confidence: 99%

“…One SR focusing on clinical efficacy of the intraoperative use of PRP during total knee arthroplasty was identified . This SR was deemed of moderate methodological quality (AMSTAR score 10/16).…”

Section: Resultsmentioning

confidence: 99%

Efficacy of platelet‐rich plasma for non‐transfusion use: Overview of systematic reviews

2019

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Platelet-rich plasma (PRP) is a blood component with a supraphysiologic concentration of platelets, usually obtained from the processing of autologous blood by different techniques, such as centrifugation and filtering. Despite the fact that strict recommendations on the most adequate techniques that should be employed for the production of PRP are still lacking, it is logical to assume that the type of method used for blood processing may determine the resulting concentration of platelet and other components, possibly impacting on its therapeutic potential. 1 The physiological rationale of the non-transfusion use of PRP relies on the high concentration of growth factors contained in platelets, such as the platelet derived-growth factor, the vascular endothelial growth factor and the fibroblast growth factor. 2 Several biological functions are attributed to these growth factors, including the proliferation of epithelial and mesenchymal cells, the stimulation of myoblasts and fibroblasts and angiogenesis. 3-5 Abstract Introduction: Platelet-rich plasma (PRP) is a blood component therapy with a supraphysiological concentration of platelets derived from allogenic or, more commonly, autologous blood. PRP has been used in different non-transfusion indications because of its role in the promotion of tissue repair and healing, in fields such as Traumatology, Dermatology and Dentistry.Objective: To provide a synthesis of the efficacy of PRP for different clinical situations. Methods: Systematic searches were carried out in MEDLINE, Embase, CochraneLibrary and LILACS in July 2018 to identify systematic reviews (SRs) of randomized clinical trials (RCTs) focusing on PRP for non-transfusion use. Two authors independently screened all retrieved references in two stages (titles and abstracts at a first stage and full texts at a second stage). The methodological quality of SRs that met the eligibility criteria was appraised by AMSTAR 2. Conclusions were based on the most recent SRs with highest quality. Results:One thousand two hundred and forty references were retrieved. After checking the inclusion criteria, 29 SRs of RCTs related to three different fields (wound care, Orthopedics and Dentistry) were included. The results suggest the benefit of PRP for different clinical situations, such as diabetic wounds, acute lesions of musculoskeletal system, rotator cuff lesions, tendinopathies, knee and hip osteoarthritis, total knee arthroplasty, allogenic bone graft for dental implants and periodontal intrabony defects. Conclusion:There is low to moderate quality evidence supporting the efficacy of PRP for specific clinical situations. The low quality of the evidence limits the certainty of these findings. Well-planned and well-conducted RCTs are still needed to further assess the efficacy of PRP.

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“…37 Despite mixed evidence, several studies have indicated that PRP reduces pain and blood loss and improves shortterm outcomes of arthroplasty. [38][39][40][41] Although the use of PRP injections during TSA has not been well studied, the relative safety and the evidence of PRP's positive effect on soft-tissue healing make the use of PRP a prudent decision to optimize TSA outcomes.…”

Section: Discussionmentioning

confidence: 99%

Stemless Total Shoulder Arthroplasty With Orthobiologic Augmentation

Nash¹,

Trang²,

Bryant³

et al. 2021

Arthroscopy Techniques

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Total shoulder arthroplasty (TSA) has evolved over the years and is used for a variety of indications, with arthritis being the most common. Stemless TSA is a unique bone-preserving design that can eliminate rotational malalignment. Additionally, recent literature has found utility in the use of biological mesh and a platelet-rich plasma injection to improve healing. The purpose of this article is to outline the process of TSA using a stemless system and how to incorporate the use of amnion matrix and platelet-rich plasma into the surgical technique.

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The effect of platelet-rich plasma on reducing blood loss after total knee arthroplasty

Cited by 17 publications

References 27 publications

Adjuvant therapies in venous leg ulcer management: A scoping review

Adjuvant therapies in venous leg ulcer management: A scoping review

Efficacy of platelet‐rich plasma for non‐transfusion use: Overview of systematic reviews

Stemless Total Shoulder Arthroplasty With Orthobiologic Augmentation

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