The Effect of Platelet-Rich Fibrin Matrix on Skin Rejuvenation: A Split-Face Comparison

Abstract

Background Despite the increasingly popular use of platelet-rich fibrin matrix (PRFM) for facial rejuvenation, no studies have evaluated its effects on skin. Objectives To determine the effect of PRFM on skin quality using the Canfield VISIA Complexion Analysis System. Methods This was a 12-week randomized, placebo-controlled trial conducted at a single center comparing two groups. Thirty patients received a PRFM injection in the mid-cheek region and nasolabial fold on one side of the face and saline on the contralateral side. The primary outcome measure was the difference between pre- and post-treatment total VISIA skin scores for each group at 6 weeks and 12 weeks. The change in sub-scores for each skin parameter was also calculated. Results There were thirty participants, with a mean (SD) age of 49.9 (13.9) years. At 6 weeks, the median decrease in total VISIA score (IQR) was -1.77 (2.36) in the PRFM group and -0.73 (2.09) in the saline group (p=0.003). The only skin parameter that had a significantly different change in score between the groups was texture (p=0.004). At 12 weeks, median score improvement was -1.31 (3.26) in the PRFM cohort and -0.76 (2.21) in the saline cohort (p=0.34). There was no statistical significance in the change in score for any of the individual skin parameters. Conclusions PRFM can objectively improve skin quality compared to placebo. Texture was the only skin parameter that significantly improved, which is consistent with PRFM's role as a filler agent. The results appear to persist for at least 6 weeks.

Uso da fibrina rica em plaquetas na estética e rejuvenescimento facial: Revisão integrativa

“…Dentre os trabalhos que avaliaram o uso do PRF como adjuvante no rejuvenescimento facial (Quadro 2), dois estudos demonstraram melhoria significante de parâmetros da pele ( (Liang et al, 2018;Hassan, Quinlan & Ghanem, 2020), dois estudos não informaram sobre os valores de significância (P<0,05) (Nacopoulos & Vesala, 2020;Karimi & Rockwell, 2019), e dois estudos não observaram mudanças significativas em nenhum dos parâmetros de pele avaliados (Wei et al, 2017;Hu, Bassiri-Tehrani & Abraham, 2020). Em todos os estudos o uso do material apresentou-se tolerável e não ocasionou efeitos adversos graves.…”

Aesthetic Rehabilitation Medicine: Enhancing Wellbeing beyond Functional Recovery

“…An RCT by Hu et al [81] analysed the effects of injections of PRP in the mid-cheek region and nasolabial fold on one side of the face and of saline on the contralateral side and reported a significant between-group difference in skin texture (p-value = 0.004) [81].…”

Evidence-Based Efficacy of Platelet-Rich Plasma in Facial Rejuvenation

“…Three very recently reported studies with high level of evidence are very informative and are worth reviewing carefully 5,6,7 . A randomized split-face clinical trial comparing a single PRP injection to saline in 27 patients with cheek rhytids of Glogau class II or greater was conducted by Alam et al 5 conducted.…”

“…4 Three very recently reported studies with high level of evidence are very informative and are worth reviewing carefully. 5,6,7 A randomized split-face clinical trial comparing a single PRP injection to saline in 27 patients with cheek rhytids of Glogau class II or greater was conducted by Alam et al 5 conducted. With blinding both participants and raters, a single PRP injection without activation was performed to 1 cheek with an equivalent volume of sterile normal saline injected to the contralateral cheek.…”

“…In another split-face randomized, placebo-controlled trial conducted by Hu et al 6 at a single center comparing platelet-rich plasma matrix injection in the mid-cheek region and nasolabial fold on 1 side and saline on the contralateral side. In this particular study outcome endpoints were well defined and were objectively measured with Canfield VISIA Complexion Analysis System (Canfield Imaging Systems, Fairfield, NJ, USA) .…”