The effect of periodontal therapy on oxidative stress biomarkers: A systematic review

Silva, Júlia Christ da; Muniz, Francisco Wilker Mustafa Gomes; Oballe, Harry Juan Rivera; Andrades, Michael Éverton; Rösing, Cassiano Kuchenbecker; Cavagni, Juliano

doi:10.1111/jcpe.12993

Cited by 26 publications

(17 citation statements)

References 65 publications

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“…The results of our meta‐analysis revealed that TOS in the saliva and GCF was significantly higher in CP patients compared to PH individuals, which was consistent with previous findings (Akalin et al., ; Wei et al., ). Moreover, a latest systematic review revealed that periodontal therapy was effective in reducing TOS in GCF, saliva, and serum in CP patients (da Silva et al., ), which further confirmed our recent results. However, no significant difference in the salivary TOS between CP patients and PH controls was reported (Zhang et al., ).…”

Section: Discussionsupporting

confidence: 89%

Oxidative stress‐related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta‐analysis

Chen

Cai

Zhao

et al. 2019

J Clinic Periodontology

153

118

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Aim:Oxidative stress (OS) biomarkers have been detected in saliva and gingival crevicular fluid (GCF) during chronic periodontitis (CP) progression; however, the relationship between OS biomarkers and CP progression remains elusive. The purpose of this meta-analysis is to investigate the relationship between local OS biomarkers and CP.Methods: This review was conducted through a systematic search from three databases. Studies on CP participants were included as an experimental group, and studies on periodontally healthy (PH) participants were included as a control. Mean effects were expressed as standardized mean difference with their associated 95% confidence intervals.Results: From a total of 2,972 articles, 32 articles fulfilled the inclusion criteria. We found a significant decrease of total antioxidant capacity and a significant increase of malondialdehyde (MDA), nitric oxide, total oxidant status (TOS), and 8-hydroxy-deoxyguanosine levels in the saliva of CP patients. Moreover, we also found an elevation of MDA level in GCF of CP group when compared with the PH group. There were no significant differences of salivary and GCF superoxide dismutase levels, salivary glutathione peroxidase level, and GCF TOS level between two groups. However, a high heterogeneity was observed among evaluated studies. Conclusions:Despite the limitations of this study, the result of our meta-analysis supported the rationale that there was a direct link between CP and OS-related biomarkers' levels in the local site, indicating the important role of OS in the onset and development of CP. K E Y W O R D S biomarker, chronic periodontitis, gingival crevicular fluid, oxidative stress, saliva | 609 CHEN Et al.

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Section: Discussionsupporting

confidence: 89%

Oxidative stress‐related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta‐analysis

Chen

Cai

Zhao

et al. 2019

J Clinic Periodontology

153

118

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“…The relationship between oxidative stress and periodontal disease is quite strong and can be a two-way path. On one hand, the presence of periodontal inflammation increases the number of oxidative stress markers, and on the other hand, it tends to potentiate aspects of periodontal destruction [35].…”

Section: Discussionmentioning

confidence: 99%

Antioxidants as Adjuvants in Periodontitis Treatment: A Systematic Review and Meta-Analysis

Castro

Duarte

Nascimento

et al. 2019

Oxidative Medicine and Cellular Longevity

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This systematic review with meta-analysis aimed to evaluate the effect of antioxidants as an adjuvant in periodontitis treatment. The following databases were consulted: PubMed, Scopus, Web of Science, Cochrane, Lilacs, OpenGrey, and Google Scholar. Based on the PICO strategy, the inclusion criteria comprised interventional studies including periodontitis patients (participants) treated with conventional therapy and antioxidants (intervention) compared to patients treated only with conventional therapy (control) where the periodontal response (outcome) was evaluated. The risk of bias was evaluated using the Cochrane RoB tool (for randomized studies) and ROBINS-I tool (for nonrandomized studies). Quantitative data were analyzed in five random effects meta-analyses considering the following periodontal parameters: clinical attachment loss (CAL), plaque index (PI), gingival index (GI), bleeding on probing (BOP), and probing depth (PD). After all, the level of certainty was measured with the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) tool. Among the 1884 studies identified, only 15 interventional studies were according to the eligibility criteria and they were included in our review. From them, 4 articles presented a high risk of bias. The meta-analysis showed a statistically significant difference for CAL (SMD 0.29 (0.04, 0.55), p=0.03, I2=13%), PI (SMD 0.41 (0.18, 0.64), p=0.0005, I2=47%), and BOP (SMD 0.55 (0.27, 0.83), p=0.0001, I2=0%). The GRADE tool showed a moderate to high certainty in the quality of evidence depending on the clinical parameter and antioxidants used. These results suggest that the use of antioxidants is an adjunct approach to nonsurgical periodontal therapy which may be helpful in controlling the periodontal status.

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“…Currently, there are numerous substances produced during periodontal tissue remodeling as reported in basic research in periodontal diseases; these substances best reflect the condition of the periodontal tissue and are so-called proximal fluids near lesion areas, also referred to as gingival crevicular fluid (GCF) that are widely used as samples [ 76 , 77 , 78 ]. The gingival sulcus is the furrow between the teeth and the gums, and the gingival sulcus exists around the teeth in a V-shaped space.…”

Section: Proteome Analysis Of Molecular Events In Oral Pathogenesimentioning

confidence: 99%

Proteome Analysis of Molecular Events in Oral Pathogenesis and Virus: A Review with a Particular Focus on Periodontitis

Tsuchida

2020

IJMS

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Some systemic diseases are unquestionably related to periodontal health, as periodontal disease can be an extension or manifestation of the primary disease process. One example is spontaneous gingival bleeding, resulting from anticoagulant treatment for cardiac diseases. One important aspect of periodontal therapy is the care of patients with poorly controlled disease who require surgery, such as patients with uncontrolled diabetes. We reviewed research on biomarkers and molecular events for various diseases, as well as candidate markers of periodontal disease. Content of this review: (1) Introduction, (2) Periodontal disease, (3) Bacterial and viral pathogens associated with periodontal disease, (4) Stem cells in periodontal tissue, (5) Clinical applications of mass spectrometry using MALDI-TOF-MS and LC-MS/MS-based proteomic analyses, (6) Proteome analysis of molecular events in oral pathogenesis of virus in GCF, saliva, and other oral Components in periodontal disease, (7) Outlook for the future and (8) Conclusions. This review discusses proteome analysis of molecular events in the pathogenesis of oral diseases and viruses, and has a particular focus on periodontitis.

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The effect of periodontal therapy on oxidative stress biomarkers: A systematic review

Abstract: Periodontal therapy reduces the levels of OxS biomarkers, even to values similar to those found in periodontally healthy individuals. Additional RCTs are warranted, as the information is mainly based on nonrandomized studies.

Cited by 26 publications

References 65 publications

Oxidative stress‐related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta‐analysis

Oxidative stress‐related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta‐analysis

Antioxidants as Adjuvants in Periodontitis Treatment: A Systematic Review and Meta-Analysis

Proteome Analysis of Molecular Events in Oral Pathogenesis and Virus: A Review with a Particular Focus on Periodontitis

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