The Effect of Oral Supplementation of Vitamin D3 on Serum Levels of Vitamin D: A Review

Abstract

and placebo (3 times daily), for 3 months. Anti-ds DNA serum levels were measured by ELISA and urine protein were measured by urine albumin creatinine ratio (UACR). Results After supplementation for 3 months, this study showed that decreased of anti-dsDNA serum levels in the supplementa-tion group was significantly greater than in the placebo group. The decreased of UACR in the supplementation group was also significantly greater than the placebo group. Conclusions Adding curcumin on vitamin D supplementation can decrease anti-dsDNA serum levels and proteinuria greater than vitamin D supplementation plus placebo in SLE patients with hipovitamin D. Background and aims Vitamin D has important roles in the regulation of the immune system in Lupus. Seventy percent of lupus patients in Indonesia are experienced hypovitamin D. Curcumin is a natural VDR ligand and has sinergic effect with vitamin D. This study was aimed to determine the effect of adding curcumin on vitamin D supplementation on IFN-g/ IL-4 ratio and IL-17/TGF-b ratio, in SLE patients with hipovi-tamin D. Methods This was a randomised controlled trial, double blind study. Forty SLE patients with hypovitamin D were studied, that randomised into two groups: 20 patients (supplementation group) received vitamin D (cholecalciferol 1200 IU daily) with curcumin 20 mg (three times daily); and 20 patients (placebo group) was given vitamin D (cholecalciferol 1200 IU daily) and placebo (3 times daily), for 3 months. Cytokines serum levels (IFN-g, IL-4, IL-17, TGF-b,) were measured by ELISA. Results After supplementation for 3 months, this study showed that decreased of IFN-g/IL-4 ratio in the supplementation group was significantly greater than in the placebo group. The decreased of IL-17/TGF-b ratio in the supplementation group was also significantly greater than the placebo group. Conclusions Adding curcumin on vitamin D supplementation can decrease IFN-g/IL-4 ratio and IL-17/TGF-b ratio than vitamin D supplementation plus placebo in SLE patients with hipovitamin D. Background and aims Vitamin D has important role in the regulation of the immune system in Lupus. 71% of lupus patients in Indonesia experienced hypovitamin D. This study was aimed to determine the effect of vitamin D supplementation on the levels of anti ds dna and degree of urine protein in lupus patients with hypovitamin D. Methods Thirty nine SLE patients with hypovitamin D were studied, that randomzed into two groups: 20 patients was given vitamin D and 19 patients received placebo for 3 months. Anti-ds DNA levels were measured by ELISA and urine protein were measured by dipstick method. Results Anti-dsDNA levels in the supplement group before and after giving vitamin D were 226.84±82.11 vs 191±72.55 (p=0.00), and the placebo group were 233.69±66.52 vs 227.72±61.21 (p=0.077). The degrees of urine protein in the supplement group before and after treatment were 24 vs 12 U/ml (p=0.003) and the placebo group were 16 vs 10 U/ ml (p=0.070). Conclusions Vitamin D supplementation plays a role on decreasi...

A vitamin D protocol post‐liver transplantation

“…A regression analysis of all reviewed studies showed a correlation of 61% which supported a consistent doseresponse relationship independent of various confounders (Jarrett et al, 2014). Additionally, the researchers found that healthy and ill individuals did not vary on response to dose, supporting a generalizable dosing schedule (Jarrett et al, 2014). In a meta-analysis of randomized controlled trials of oral vitamin D supplementation, it was found that high-dose VDS (> 800IU/day) was more beneficial in the prevention of hip fracture and any nonvertebral fracture in people 65 years and older (Bischoff-Ferrari et al, 2012).…”

“…A regression analysis of all reviewed studies showed a correlation of 61% which supported a consistent doseresponse relationship independent of various confounders (Jarrett et al, 2014). Additionally, the researchers found that healthy and ill individuals did not vary on response to dose, supporting a generalizable dosing schedule (Jarrett et al, 2014).…”

“…In a meta-analysis of randomized controlled studies, a strong dose-response was found between the amount of supplement and change in serum VD (Jarrett, Ducasa, Buller, & Berwick, 2014). Most important, these results did not change when the review limited the results to studies using healthy individuals (Jarrett et al, 2014).…”

“…In a meta-analysis of randomized controlled studies, a strong dose-response was found between the amount of supplement and change in serum VD (Jarrett, Ducasa, Buller, & Berwick, 2014). Most important, these results did not change when the review limited the results to studies using healthy individuals (Jarrett et al, 2014). Vitamin D insufficiency and deficiency are widespread in close to half the population of healthy individuals in industrialized countries (Iruzubieta, et al, 2014).…”

“…Before patient recruitment began, the SI met with statisticians and discussed an appropriate sample size. It was assumed that approximately 70% of the patients would respond to the dose indicated by Endocrinology as the expectation was that most patients would reach the minimum target level of 30 ng/mL as found in the meta-analysis by Jarrett, Ducasa, Buller &Berwick, 2014 andPilz et al, 2016. Based on this expectation a power analysis was calculated to determine appropriate sample size that would give a confidence interval (CI) of >90%.…”