The effect of oral omega-3 polyunsaturated fatty acid supplementation on muscle maintenance and quality of life in patients with cancer: A systematic review and meta-analysis

Lam, Chung Nga; Isenring, Elisabeth; Schueren, M.A.E. van Bokhorst-de van der; Meij, Barbara S. van der

doi:10.1016/j.clnesp.2020.09.788

Cited by 3 publications

(3 citation statements)

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“…Ma’s research showed that ω -3 PUFAs downregulated CRP levels and reduced the duration of systemic inflammatory response syndrome (SIRS) [ 78 ]. However, studies by Lam CN and Carvalho TC showed that ω -3 PUFAs had no significant effect on nutritional improvement and inflammation regulation in patients with cancer [ 79 , 80 ]. Some randomized controlled trials have studied the therapeutic effect of ω -3 PUFAs on patients with lung cancer during radiotherapy and chemotherapy, but there is no corresponding meta-analysis study.…”

Section: Clinical Application Of Metabolism and Immunonutrition In Ta...mentioning

confidence: 99%

Immunonutrition, Metabolism, and Programmed Cell Death in Lung Cancer: Translating Bench to Bedside

Fedele,

Santoro,

Pini

et al. 2024

Biology

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Lung cancer presents significant therapeutic challenges, motivating the exploration of novel treatment strategies. Programmed cell death (PCD) mechanisms, encompassing apoptosis, autophagy, and programmed necrosis, are pivotal in lung cancer pathogenesis and the treatment response. Dysregulation of these pathways contributes to tumor progression and therapy resistance. Immunonutrition, employing specific nutrients to modulate immune function, and metabolic reprogramming, a hallmark of cancer cells, offer promising avenues for intervention. Nutritional interventions, such as omega-3 fatty acids, exert modulatory effects on PCD pathways in cancer cells, while targeting metabolic pathways implicated in apoptosis regulation represents a compelling therapeutic approach. Clinical evidence supports the role of immunonutritional interventions, including omega-3 fatty acids, in augmenting PCD and enhancing treatment outcomes in patients with lung cancer. Furthermore, synthetic analogs of natural compounds, such as resveratrol, demonstrate promising anticancer properties by modulating apoptotic signaling pathways. This review underscores the convergence of immunonutrition, metabolism, and PCD pathways in lung cancer biology, emphasizing the potential for therapeutic exploration in this complex disease. Further elucidation of the specific molecular mechanisms governing these interactions is imperative for translating these findings into clinical practice and improving lung cancer management.

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Section: Clinical Application Of Metabolism and Immunonutrition In Ta...mentioning

confidence: 99%

Immunonutrition, Metabolism, and Programmed Cell Death in Lung Cancer: Translating Bench to Bedside

Fedele,

Santoro,

Pini

et al. 2024

Biology

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“…A meta-analysis showed that ω -3 PUFAs could improve the nutritional status of patients after gastrectomy of gastric cancer and downregulate the levels of inflammatory indicators, such as C-reactive protein (CRP) and interleukin 6 (IL-6) [ 7 ]. However, studies by Lam CN and Carvalho TC showed that ω -3 PUFAs had no significant effect on nutritional improvement and inflammation regulation in cancer patients [ 8 , 9 ]. Some randomized controlled trials have studied the therapeutic effect of ω -3 PUFAs on patients with lung cancer during radiotherapy and chemotherapy, but there is no corresponding meta-analysis study.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of ω-3 Polyunsaturated Fatty Acids in Patients with Lung Cancer Undergoing Radiotherapy and Chemotherapy: A Meta-Analysis

Xin

Zhou

Rao

2022

International Journal of Clinical Practice

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Background. Radiotherapy and chemotherapy in patients with lung cancer can lead to a series of problems such as malnutrition and inflammatory reaction. Some studies have shown that ω-3 polyunsaturated fatty acids (PUFAs) could improve malnutrition and regulate inflammatory reaction in these patients, but no relevant meta-analysis exists. Methods. We systematically searched randomized controlled trials of ω-3 PUFAs in the adjuvant treatment of lung cancer in the PubMed, EMBASE, Cochrane Library, Web of Science, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), and Wanfang databases. Relevant outcomes were extracted, and we pooled standardized mean differences (SMDs) using a random or fixed-effects model. The risk of bias was evaluated according to the Cochrane Handbook (version 15.1). The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Results. A total of 7 studies were included. The SMDs (95% CI) of body weight change, albumin change, energy intake, and protein intake at the end of intervention were 1.15 (0.50, 1.80), 0.60 (0.11, 1.09), 0.39 (−0.10, 0.89), and 0.27 (−0.04, 0.58), respectively. The SMDs (95% CI) of CRP change and TNF-α change were −3.44 (−6.15, −0.73) and −1.63 (−2.53, −0.73), respectively. Conclusions. ω-3 PUFAs can improve nutritional status and regulate indicators of inflammation in patients with lung cancer undergoing radiotherapy and chemotherapy. This study was registered in the PROSPERO (registration number: CRD42022307699).

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“…The proliferation and differentiation of SCs can be modulated by nutrients such as dietary carbohydrate, vitamin D, and Vitamin E ( Chapalamadugu et al, 2009 ; Alami-Durante et al, 2011 ; Khor et al, 2016 ; Braga et al, 2017 ); however, their effect varies depending on the origin of muscle type ( Powell et al, 2014 ). Omega-3 polyunsaturated fatty acids (PUFAs) have been shown to increase the functional capacity of the muscle and enable maintenance of muscle mass in aging and chronic disease (reviewed by McGlory et al, 2019 ; Lam et al, 2020 ). Omega-3 PUFAs have the potential to regulate the complex process of skeletal muscle regeneration and differentiation due to their ability to regulate gene expression ( Price et al, 2000 ), mitochondria biogenesis ( Katyare and Mali, 2016 ), and inflammation ( Calder, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Regulation of Skeletal Muscle Satellite Cell Differentiation by Omega-3 Polyunsaturated Fatty Acids: A Critical Review

Isesele

Mazurak

2021

Front. Physiol.

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Skeletal muscle is composed of multinuclear cells called myofibres, which are formed by the fusion of myoblasts during development. The size of the muscle fiber and mass of skeletal muscle are altered in response to several pathological and physiological conditions. Skeletal muscle regeneration is primarily mediated by muscle stem cells called satellite cells (SCs). In response to injury, these SCs replenish myogenic progenitor cells to form new myofibers to repair damaged muscle. During myogenesis, activated SCs proliferate and differentiate to myoblast and then fuse with one another to form muscle fibers. A reduced number of SCs and an inability to undergo myogenesis may contribute to skeletal muscle disorders such as atrophy, cachexia, and sarcopenia. Myogenic regulatory factors (MRF) are transcription factors that regulate myogenesis and determines whether SCs will be in the quiescent, activated, committed, or differentiated state. Mitochondria oxidative phosphorylation and oxidative stress play a role in the determination of the fate of SCs. The potential activation and function of SCs are also affected by inflammation during skeletal muscle regeneration. Omega-3 polyunsaturated fatty acids (PUFAs) show promise to reduce inflammation, maintain muscle mass during aging, and increase the functional capacity of the muscle. The aim of this critical review is to highlight the role of omega-3 PUFAs on the myogenic differentiation of SCs and pathways affected during the differentiation process, including mitochondrial function and inflammation from the current body of literature.

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The effect of oral omega-3 polyunsaturated fatty acid supplementation on muscle maintenance and quality of life in patients with cancer: A systematic review and meta-analysis

Cited by 3 publications

References 0 publications

Immunonutrition, Metabolism, and Programmed Cell Death in Lung Cancer: Translating Bench to Bedside

Immunonutrition, Metabolism, and Programmed Cell Death in Lung Cancer: Translating Bench to Bedside

Efficacy of ω-3 Polyunsaturated Fatty Acids in Patients with Lung Cancer Undergoing Radiotherapy and Chemotherapy: A Meta-Analysis

Regulation of Skeletal Muscle Satellite Cell Differentiation by Omega-3 Polyunsaturated Fatty Acids: A Critical Review

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