The Effect of On‐Pump and Off‐Pump Bypass Operations on Oxidative Damage and Antioxidant Parameters

Abstract

Objective The aim of the study is to determine the oxidative status in on-pump and off-pump coronary artery surgery and contribute to possible surgical choices in clinical practices in accordance with the information obtained as a result of this study. Methods 52 patients undergoing open heart surgery (26 patients in on-pump group and 26 patients in off-pump group) were included in the study. MDA, GPx, GSH, CAT, and SOD were investigated in blood samples. Results In the on-pump group, it was determined that there were a significant increase in MDA level in the peroperative period compared to the preoperative and postoperative periods and a significant increase in GSH level in the postoperative period than in the preoperative period. Additionally, while there was a significant decrease in CAT activity in the postoperative period than in the peroperative period, there was a statistically significant increase in SOD enzyme activity in the postoperative period compared to the preoperative and peroperative periods. A statistically significant increase was observed in SOD enzyme activity in the postoperative period in on-pump compared to off-pump group. Conclusion It is thought that this oxidative damage can be suppressed by administering a suitable antioxidant supplement in the preoperative and peroperative periods among patients undergoing the on-pump operation.

Effect of mechanical ventilation during cardiopulmonary bypass on oxidative stress: a randomized clinical trial

“…An intragroup analysis has indicated that the postoperative CAT level of Group 1 significantly increased compared to the preoperative level. Conforming to a previous study, 27 the postoperative CAT level of Group 2 in our study significantly decreased compared with its preoperative level. In a study in which a continuous mechanical ventilator strategy was used, the thiol and native thiol levels were significantly higher at 24 hours postoperatively than those of patients who were not ventilated.…”

“…However, no significant differences were found in the postoperative period. 27 In groups 1 and 2 of our study, the changes from the preoperative period to the postoperative period were minimal and not significant. Conversely, the intraoperative and postoperative MDA levels of Group 3 were significantly higher than the preoperative levels.…”

“…Regarding the GSH and CAT levels, the on-pump and off-pump groups had no significant differences during the preoperative, intraoperative, and postoperative periods. 27 …”

The Correlation of Lipid Peroxidation and Antioxidant Capacity on Perioperative Outcomes in On-Pump CABG in Adults

“…It has been established that patients with hyperlipidemia have impaired antioxidant defense systems. According to previous studies, superoxide dismutase and glutathione peroxidase activities in hyperlipidemic patients have been demonstrated to be significantly lower than that in normolipidemic patients ( 26 ). Therefore, it is reasonable to attribute the higher MDA levels in hyperlipidemic patients to impaired or weak oxidative stress defense system.…”

Influence of Cardiopulmonary Bypass on Some Antioxidants and Haematological Measurements in Cardiac Patients and Associated Diseases

“…Malondialdehyde (MDA) is considered as one of the most indicators of oxidative stress and damage produced as a result of lipid peroxidation, also the same author recorded an increase in the level of MDA in the early postoperative stage as an indicator of reperfusion damage that occurs immediately after open-heart surgery. According to Dogan and Turker (2017) showed an excessive production of free radicals mainly in open-heart surgery leading to an increase in oxidative stress systemically which is commonly related to the higher production of MDA. Arif et al (2019)…”