“…S6). Frequency shifts originating from susceptibility changes can affect not only BOLD fMRI 27,49 but also CEST-fMRI data, as evidenced by our simulations and hyperoxia experiments. By using the water frequency and linewidth changes between oxy- and deoxygenated blood, Song et al .…”
Section: Discussionsupporting
confidence: 53%
“…4a). While the susceptibility change caused by the saturation of the hemoglobin with oxygen is expected to induce a negative frequency shift 27 , during these hyperoxia experiments we observe a positive shift due to the presence of molecular oxygen (paramagnetic). Changes in the levels of brain glucose have been reported upon hyperoxia 28 ; it is clear, however, that the I ratio (1.2 ppm) increase we observe upon hyperoxia is dominated by susceptibility effects that overpower such changes.Figure 5Results of glucoCEST-MRI and fMRS experiments upon hyperoxia.…”
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…S6). Frequency shifts originating from susceptibility changes can affect not only BOLD fMRI 27,49 but also CEST-fMRI data, as evidenced by our simulations and hyperoxia experiments. By using the water frequency and linewidth changes between oxy- and deoxygenated blood, Song et al .…”
Section: Discussionsupporting
confidence: 53%
“…4a). While the susceptibility change caused by the saturation of the hemoglobin with oxygen is expected to induce a negative frequency shift 27 , during these hyperoxia experiments we observe a positive shift due to the presence of molecular oxygen (paramagnetic). Changes in the levels of brain glucose have been reported upon hyperoxia 28 ; it is clear, however, that the I ratio (1.2 ppm) increase we observe upon hyperoxia is dominated by susceptibility effects that overpower such changes.Figure 5Results of glucoCEST-MRI and fMRS experiments upon hyperoxia.…”
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…As a result, the concomitant RF irradiation effects can be fully compensated by correcting the experimentally obtained CEST/APT contrast with the derived labeling coefficient and spillover factor. In addition, there can be some concern that fast repetition of excitation and refocusing RF pulses may induce accidental MT effects, as reported previously (20). Given the short duration of imaging RF and the long repetition time, however, such accidental MT effects are expected to be minimal.…”
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…It has been reported that tissue MTR decreases with neuronal depolarization (36, 37). This MTR decrease has been attributed largely to a change in direct water saturation caused by the alteration in tissue T 2 during neuronal activation, as recently shown for pure water saturation by (38).…”
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).
Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.
The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).
Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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