The effect of non‐thermal atmospheric pressure plasma application on wound healing after gingivectomy

Abstract

Recent studies have indicated the potential benefits of Non‐thermal atmospheric pressure plasma (NTAPP) as a novel therapeutic approach. The purpose of the current study was thus to assess the effect of NTAPP on gingival wound healing. Fifteen patients with bilaterally symmetrical gingival hyperplasia were included in the study. After gingivectomy and gingivoplasty, the left‐hand side of the symmetrical surgical area was irradiated with NTAPP (plasma jet kINPen 11). Digital photographs of the gingival wounds were taken at baseline and days 3, 7, and 14. Wound epithelialisation was evaluated. Landry Wound Healing Index (WHI) scores and visual analogue scale (VAS) scores were also recorded. There were significant differences between the epithelialisation of the NTAPP‐treated sites and the control sites after the surgical procedures. The NTAPP‐treated sites had significantly smaller stained surface areas compared with the control sites on the 3rd, 7th, and 14th days (P < .05). The NTAPP‐treated sites had better WHI scores than the control sites throughout the follow‐up period (P < .05). It can be concluded that NTAPP enhances epithelialisation and stimulates wound healing after gingivectomy and gingivoplasty. However, further clinical studies with larger sample sizes are needed to determine the exact benefits of NTAPP for gingival wound healing.

Efficacy of hyaluronic acid gel and photobiomodulation therapy on wound healing after surgical gingivectomy: a randomized controlled clinical trial

“…Many studies showed that PBMT was an effective adjunctive treatment that appeared to promote healing following gingivectomy [ 37 – 39 ]. Besides PBMT, the use of many other topical therapeutic agents have been reported in the literature to improve the wound healing after gingivectomy procedure such as: hyaluronic acid (HA) gel, herbal gel, non-thermal atmospheric pressure plasma application and vitrocure ® gel [ 2 , 40 , 41 ].…”

The therapeutic perspective of cold atmospheric plasma in periodontal disease

“…The gingival wounds of 15 patients after gingivectomy and gingivoplasty were subjected to CAP. The author observed that wound epithelialization was enhanced and wound areas were decreased on the 3rd, 7th, and 14th days after CAP (Kusakci‐Seker & Demirayak‐Akdemir, 2020). In addition, a randomized control clinical trial with 40 patients first evaluated the influence of CAP on postoperative morbidities in the palatal donor area using a free gingival graft (Pekbağrıyanık et al, 2021).…”

“…Meanwhile, recent clinical studies have demonstrated the benefits of CAP on gingival wound healing (Kusakci‐Seker & Demirayak‐Akdemir, 2020; Pekbağrıyanık et al, 2021). The gingival wounds of 15 patients after gingivectomy and gingivoplasty were subjected to CAP.…”

The effects of injectable platelet-rich fibrin application on wound healing following gingivectomy and gingivoplasty operations: single-blind, randomized controlled, prospective clinical study

“…A gingivectomy operation contributes to periodontal tissue health by removing excess gingival tissues. It improves aesthetics by providing normal physiological contours [ 2 ]. Wound healing after a gingivectomy and gingivoplasty is in the form of secondary wound healing [ 3 ].…”

“…The maturation of the connective tissue occurs in 7 weeks [ 1 , 4 ]. Various products, such as low-dose laser applications, herbal products, hemostatic agents, ozone, antiseptic/antibacterial agents with bioactive material, and platelet concentrates, have been tested to accelerate wound healing after a gingivectomy and gingivoplasty [ 2 , 5 ].…”