The effect of non‐surgical periodontal treatment on gingival crevicular fluid periostin levels in patients with gingivitis and periodontitis

Arslan, Rana; Hendek, Meltem Karşıyaka; Kısa, Üçler; Olgun, Ebru

doi:10.1111/odi.13664

Cited by 7 publications

(8 citation statements)

References 50 publications

(55 reference statements)

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“…These results may support the idea that periodontal inflammation can cause of periostin downregulation. However, in agreement with the present study, Arslan and co-workers found that periostin GCF levels decreased from the periodontitis group to the gingivitis and to the healthy control group [ 16 ]. As in the present study, samples had been taken from bleeding sites (GI = 2 and BOP positive).…”

Section: Discussionsupporting

confidence: 93%

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Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis

et al. 2022

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Objectives IL-23p19/Ebi3 (IL-39) was described as a new IL-12 family member. The aim of this study is to evaluate the gingival crevicular fluid (GCF) IL-39 levels in periodontal diseases and health and to correlate them to GCF levels of IL-1β and periostin. Materials and methods Sixty-six adult patients were included in the study. The study design was comprised of three groups, each containing 22 individuals: the periodontally healthy (PH), gingivitis (G), and periodontitis (P) groups. The clinical periodontal parameters were recorded and GCF samples were collected from the participants. GCF interleukin (IL)-39, IL-1β, and periostin levels were examined using the enzyme-linked immunosorbent assay. Results GCF IL‑1β, periostin, and IL-39 levels were higher in the P and G groups than in the PH group (p < 0.001). Positive correlations were detected between all GCF biochemical parameters and clinical periodontal parameters (p < 0.05). In the multivariate generalized linear regression analysis, the P (β = 37.6, 95% CI = 22.9–52.4) and G (β = 28.4, 95% CI = 15.8–41) groups were associated with GCF IL-39 levels (p < 0.001). Conclusion IL-39 levels were elevated in the presence of periodontal disease paralleling the increase in IL‑1β and periostin levels. IL-39 may have a role in the periodontal inflammation process. Statement of clinical relevance IL-39, a new cytokine from the IL-12 family, can be a possible predictor marker of periodontal diseases.

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Section: Discussionsupporting

confidence: 93%

“…Periostin expression in the periodontal ligament is regulated by TGF-β, mechanical stress such as during mastication and tooth movement [ 11 ]. A study stated that periostin values increased in the presence of periodontitis in gingival crevicular fluid (GCF) [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis

et al. 2022

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“…PDLFs transfected with GFP-tagged periostin or an empty lentiviral expression vector were pretreated with 30 μM ML385 for 3 h, followed by 5 μg/ml LPS for 24 h. than that of the healthy group (Akman et al, 2018). Another study revealed the opposite result (Arslan et al, 2021). Our results indicated that increasing concentrations of LPS decreased the protein and mRNA expression levels of periostin.…”

Section: Discussionmentioning

confidence: 59%

“…Moreover, the level of periostin was also lower in peri‐implant sulcular fluid of peri‐implantitis than that of the healthy group(Akman et al, 2018). Another study revealed the opposite result (Arslan et al, 2021). Our results indicated that increasing concentrations of LPS decreased the protein and mRNA expression levels of periostin.…”

Section: Discussionmentioning

confidence: 90%

Periostin regulates LPS‐induced apoptosis via Nrf2/HO‐1 pathway in periodontal ligament fibroblasts

Jiang

Yang

et al. 2022

Oral Diseases

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Objective: Periostin is important for the maintenance of periodontal tissue, but its role in periodontitis is controversial. This research investigated the effect of periostin in periodontitis and the underlying mechanism. Design: Mouse periodontitis models in vivo and inflammation model in vitro which were induced by Porphyromonas gingivalis lipopolysaccharide were established to evaluate periostin expression. Human periodontal ligament fibroblasts (PDLFs) were treated with lipopolysaccharide and N-acetylcysteine, fluorescence staining, flow cytometry, Western blot, and qRT-PCR were used to detect reactive oxygen species (ROS), periostin expression, and apoptosis-related makers. The periostin gene was successfully transfected into PDLFs to verify the effect of periostin on apoptosis. Then, the Nrf2 inhibitor was added to clarify the mechanism. Results: Periostin expression decreased in the periodontal ligaments of mouse periodontitis models and lipopolysaccharide-induced PDLFs. Lipopolysaccharide promoted the activation of ROS and apoptosis in PDLFs, whereas N-acetylcysteine reversed this condition. Overexpression of periostin suppressed apoptosis of PDLFs and reversed the inhibitory effect of lipopolysaccharide on nuclear Nrf2 expression. Moreover, the Nrf2 inhibitor attenuated the protective effect of periostin on lipopolysaccharideinduced apoptosis. Conclusions: Lipopolysaccharide induced apoptosis in PDLFs by inhibiting periostin expression and thus Nrf2/HO-1 pathway, indicating that periostin could be a potential therapeutic target for periodontitis.

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“…In the study conducted by Arslan R et al [ 27 ], the authors reported that the level of periostin in the GCF is significantly higher in people with periodontitis. Also, the level of periostin in the GCF of people with gingivitis was lower than the periodontitis group, but significantly higher than that of healthy people.…”

Section: Discussionmentioning

confidence: 99%

Periostin level in gingival crevicular fluid in periodontal disease: a systematic review and meta-analysis

et al. 2023

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Background Periostin, a secreted adhesion molecule, is a matricellular protein secreted most in periodontal ligament and periosteum. Periostin is also needed for integrity and maturation of periodontal tissue. This meta-analysis was conducted to compare the gingival crevicular fluid (GCF) periostin levels in subjects having periodontal disease and healthy periodontium. Methods In this meta-analysis, three international database including PubMed, Scopus and Web of Science were searched and 207 studies retrieved. Also, the Google Scholar was searched to find more related studies (two studies were found). To assess the risk of bias of included studies, the Newcastle–Ottawa assessment scale adapted for case–control was used. Finally, required data was extracted and included into analysis. All statistical analysis were done using Stata software. Results Eight studies were included in this meta-analysis. Results showed that GCF periostin level is significant lower in chronic periodontitis group compare to healthy people (the standardized mean difference (SMD) = -3.15, 95% CI = -4.45, -1.85, p < 0.001). The syntheses of studies shown a significant decrease in the periostin level of chronic periodontitis patients compared to the gingivitis patients (SMD = -1.50, 95%CI = -2.52, -0.49, P = 0.003), while the mean level of periostin between the gingivitis patients and healthy group has no significant difference (SMD = -0.88, 95%CI = -2.14, 0.38, P = 0.173). Conclusion The mean concentration of GCF periostin in people with chronic periodontitis significantly decreased compared to people with gingivitis and also compared to healthy people, while no significant difference was observed between the two groups with gingivitis and healthy people. Therefore, this marker may be used as a diagnostic criterion for the disease, which requires further studies.

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The effect of non‐surgical periodontal treatment on gingival crevicular fluid periostin levels in patients with gingivitis and periodontitis

Cited by 7 publications

References 50 publications

Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis

Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis

Periostin regulates LPS‐induced apoptosis via Nrf2/HO‐1 pathway in periodontal ligament fibroblasts

Periostin level in gingival crevicular fluid in periodontal disease: a systematic review and meta-analysis

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