The Effect of Nasal Passage Characteristics on Particle Deposition

Kesavanathan, Jana; Bascom, Rebecca; Swift, David L.

doi:10.1089/jam.1998.11.27

Cited by 40 publications

(27 citation statements)

References 13 publications

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“…We speculate that the increased PDE relates to increased turbulent flow that occurs with decreased A,,,,. These results agree with our previous study (Kesavanathan et al, 1998).…”

Section: Empirical Equationssupporting

confidence: 94%

“…Nasal resistance was not measured in this study because our previous study showed that not all subjects were able to perform the nasal panting maneuver required to measure nasal resistance (Kesavanathan et al, 1998). Since many factors influence the impaction of particles in the nasal passage (Hounam and Morgan, 1977), combining the factors as an equation may be a good way of explaining PDE.…”

Section: Empirical Equationsmentioning

confidence: 99%

“…Our previous study evaluated the effect of nostril shape (ellipticity, E) and minimum nasal cross-sectional area (A,,,,) on nasal particle deposition at a 30 llmin constant passive flow rate, and developed an empirical nasal particle deposition efficiency (PDE) equation (Kesavanathan et al, 1998) 1998 where PDE = particle deposition efficiency, d = particle diameter (pm), AnIl1, = minimum nasal cross sectional area (crn2), and E = nostril length to width ratio (ellipticity). Forty male and female human subjects from different ethnic groups participated in the abovc study.…”

mentioning

confidence: 99%

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Human Nasal Passage Particle Deposition: The Effect of Particle Size, Flow Rate, and Anatomical Factors

Kesavanathan

Swift

1998

Aerosol Science and Technology

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“…We speculate that the increased PDE relates to increased turbulent flow that occurs with decreased A,,,,. These results agree with our previous study (Kesavanathan et al, 1998).…”

Section: Empirical Equationssupporting

confidence: 94%

Section: Empirical Equationsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Human Nasal Passage Particle Deposition: The Effect of Particle Size, Flow Rate, and Anatomical Factors

Kesavanathan

Swift

1998

Aerosol Science and Technology

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“…Some recent studies suggest that this may in fact be the case for inhaled particles. Kesavanathan et al (16,17) attempted to link specific nasal characteristics with total and regional particle deposition in the adult nose. They showed that nasal particle deposition efficiency for 2-6 m was increased with decreased minimal cross-sectional area of the nasal passages and increasing ellipticity of the nostrils, with the latter being significantly greater in Caucasians than in African-Americans.…”

mentioning

confidence: 99%

Nasal contribution to breathing with exercise: effect of race and gender

Bennett

Zeman²,

Jarabek³

2003

Journal of Applied Physiology

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Because the nose acts as a filter to prevent penetration of toxic particles and gases to the lower respiratory tract, the route of breathing, oral vs. nasal, may be an important determinant of toxicant dose to the lungs. Using respiratory inductance plethysmography and a nasal mask fitted with flowmeter, we measured the nasal contribution to breathing at rest and during exercise (to 60% maximum workload) in healthy young adults (men/women = 11/11 and Caucasian/African-American = 11/11). We found that the nasal contribution to breathing is less during submaximal exercise in the Caucasians vs. African-Americans (e.g., at 60% maximum workload, mean nasal-to-total ventilation ratio = 0.40 ± 0.21 and 0.65 ± 0.24, respectively, P < 0.05). This difference is likely due to the African-Americans' ability to achieve higher maximal inspiratory flows through their nose than the Caucasians. Men also had a lesser nasal contribution to breathing during exercise compared with women. This is likely due to greater minute ventilations at any given percentage of maximum workload in men vs. women.

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“…(An earlier study by Cheng et al (1993) did measure local deposition patterns of Thoron progeny in a segmented airway, but the data were not correlated with geometrical airway parameters.) Kesavanathan et al (1998) investigated the effect of nostril geometry on particle deposition in the anterior part of the nasal airway in 40 human volunteers. A radioactively labeled polydisperse di-ethyhexyl sebacate aerosol detected with a scintillating detector was used in their experiment.…”

mentioning

confidence: 99%