The Effect of Metronidazole on the Viability of Cal-27 Tongue Cancer Cells.

Abstract

Metronidazole (2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol) is one of the most commonly prescribed antibacterial and antiprotozoal medications worldwide. For over 50 years it has been widely utilised in the treatment of numerous diseases such as anaerobic bacterial infections (Bacteroides, Fusobacterium, Clostridium, Peptostreptococcus or Prevotella species), trichomoniasis, bacterial vagi-nosis, enteritis infectious, Crohnís disease, endocarditis, aspiration pneumonia, periodontitis, amoebic dysentery, Helicobacter pylori or Giardia lamblia infections. It has been included in perioperative prevention protocols for bowel or head and neck surgeries as well (1, 2, 3). Moreover, it has been used is cancer treatment, with both radiotherapy and chemotherapy, making both treatment modalities PHARMACOLOGY