The Effect of Low Concentrations of Carboxyhemoglobin on the "Altitude Tolerance" of Man

Lilienthal, J. L.; Fugitt, Charles H.

doi:10.1152/ajplegacy.1946.145.3.359

Cited by 33 publications

(7 citation statements)

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“…It is possible that the failure of carbon monoxide to stimulate ventilation may in fact be the result of interference with central integrative mechanisms. Contrary to an often quoted statement that this is unlikely (32) there is considerable evidence that carbon monoxide can substantially disrupt central nervous system function at relatively small concentrations (33)(34)(35). For these reasons there must be some reservation regarding the ultimate significance of the effects of carbon monoxide on ventilation.…”

Section: Methodsmentioning

confidence: 89%

Hypoxic ventilatory drive in normal man

Weil¹,

Byrne-Quinn²,

Sodal³

et al. 1970

J. Clin. Invest.

374

172

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A B S T R A C TFor purposes of quantitation these curves are approximated by a simple hyperbolic function, the parameters of which are evaluated by a least squares fit of the data. The parameter A denotes curve shape such that the higher the value of A, the greater the increase in ventilation for a given decrease in PAO2 and hence the greater the hypoxic drive. Curves are highly reproducible for each subject and curves from different subjects are similar. In 10 normal subjects at resting PAcO2, A = 180.2 +14.5 (SEM). When PACO, is adjusted to levels 5 mm Hg above and below control in six subjects A = 453.4 ±103 and 30.2 ±6.8 respectively. These latter values differed significantly from control (P < 0.05). These changes in curve shape provide a clear graphic description of interaction between hypercapnic and hypoxic ventilatory stimuli. At normal PACo2 the VE-PAO2 curve has an inflection zone located over the same P02 range as the inflection in the oxygenhemoglobin dissociation curve. This indicated that ventilation might be a linear function of arterial oxygen saturation or content. Studies in four subjects have

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Section: Methodsmentioning

confidence: 89%

Hypoxic ventilatory drive in normal man

Weil¹,

Byrne-Quinn²,

Sodal³

et al. 1970

J. Clin. Invest.

374

172

View full text Add to dashboard Cite

show abstract

“…MacFarland, Roughton, Halperin & Niven (1944) demonstrated impairment of visual discrimination for brightness with CO~b levels as low as 4 per cent. Lilienthal and Fugitt (1946) noted lowered flicker fusion at an altitude of 6000 feet with COHb levels between 5 and 10 percent. Decrement in limb coordination has been reported with the same COHb levels at normal atmospheric pressure (Trouton & Eysenck, 1961).…”

Section: Discussionmentioning

confidence: 97%

Effects of short-term low level carbon monoxide exposure on human performance.

O'Donnell¹,

Mikulka²,

Heinig³

et al. 1970

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“…COHb strongly correlated with inhaled CO concentration reaching approximately 20% at 100 ppm and 30% at 200 ppm CO (Peterson, 1970;Peterson and Stewart, 1970). Hosko (1970) found that at COHb more than 20%, visually evoked responses were altered in human volunteers; at high altitudes, even a much smaller increase in COHb (5-10%) can exert similar effects (Lilienthal and Fugitt, 1945).…”

Section: Acute Toxicitymentioning

confidence: 99%

“…For example, two healthy men died at a height of approximately 6,000 m in Alaska from exposure to CO generated just by a cooking stove in their tent (Foutch and Henrichs, 1988). Even a 5-10% increase in COHb can cause appreciable deterioration in flicker fusion frequency at high altitudes (Lilienthal and Fugitt, 1945). Also, altitude exaggerates CO toxicity in subjects with coronary artery disease (McGrath, 2006).…”

Section: Acute Toxicitymentioning

confidence: 99%