The effect of isovitexin on lipopolysaccharide-induced renal injury and inflammation by induction of protective autophagy

Tseng, Chiao-Yun; Yu, Peirong; Hsu, Cheng‐Chin; Lin, Hui-Hsuan; Chen, Jing-Hsien

doi:10.1016/j.fct.2022.113581

Cited by 7 publications

(2 citation statements)

References 67 publications

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“…Isovitexin (also known as homovitexin or saponaretin) is a naturally occurring bioactive glycosyl flavonoid constituent of many medicinal plants (16). Isovitexin and its parent compound vitexin are both derivatives of apigenin, a wellknown flavone with antimalarial properties that have been reported in several studies.…”

Section: Resultsmentioning

confidence: 99%

Isovitexin, the main phytoconstituent of Anthocleista djalonensis, may be responsible for the plant's antimalarial properties

Chika C. Abba,

Mildred C. Egwuatu,

Onyekachi Johnson

et al. 2024

Magna Sci. Adv. Biol. Pharm.

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Several studies have reported on the antimalarial properties of Anthoclestia djalonensis. This study was therefore conducted to validate this report and identify the phytocomponents of the plant that might be responsible for its antimalarial activity. The crude methanol extract of the plant was fractionated into ethyl acetate and n-butanol fractions using the liquid-liquid fractionation method. After a 5-day curative study, the plant's crude extract and fractions at 200 mg/kg showed varying levels of antimalarial properties, with the n-butanol fraction showing the highest parasite clearance (86.8%), followed by the crude extract (77.3%), and the ethyl acetate fraction (49.32%). HPLC analysis of the ethyl acetate and n-butanol fractions revealed isovitexin and its derivative as the plant's major phytoconstituents, and these compounds may be responsible for the plant's antimalarial property.

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Section: Resultsmentioning

confidence: 99%

Isovitexin, the main phytoconstituent of Anthocleista djalonensis, may be responsible for the plant's antimalarial properties

Chika C. Abba,

Mildred C. Egwuatu,

Onyekachi Johnson

et al. 2024

Magna Sci. Adv. Biol. Pharm.

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“…Selenium treatment differentially influenced vitexin metabolism among germplasms, which increased vitexin accumulation by 1.43, 2.67, 1.79, and 1.76 folds respectively in Bailv 9, 122-225, 1009-2-5 and Weilv 12 but decreased it in Pinlv2011-12 and Jilv 0816 (p < 0.05). The isovitexin content was Vitexin and isovitexin have important pharmacological activities against various disorders, including diabetes [34], endometrial cancer [35], and renal injury [36]. However, vitexin and isovitexin, the major flavonoids of mungbean [37,38], decrease during germination [16,39].…”

Section: Selenium Treatment Increases Mungbean Flavonoidsmentioning

confidence: 99%

Selenium Differentially Regulates Flavonoid Accumulation and Antioxidant Capacities in Sprouts of Twenty Diverse Mungbean ( (L.) Wilczek) Genotypes

Zhao,

Jin,

Yang

et al. 2024

Phyton

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Seed germination with selenium (Se) is promising for producing Se-biofortified foods. Mungbean (Vigna radiata (L.) Wilczek) sprout is freshly eaten as a salad dressed with sauce, making it superior for Se biofortification. Since the Se safety range for the human body is extremely narrow, it is imperative to evaluate the genotypic responses of mungbean sprouts to Se. This study evaluated the Se enrichment capacity and interaction with flavonoids and antioxidant systems in sprouts of 20 mungbean germplasms. Selenium treatment was done by immersing mungbean seeds in 20 μM sodium selenite solution for 8 h. Afterward, the biomass, Se amounts, flavonoid (particularly vitexin and isovitexin) contents, antioxidant capacity, and key biosynthetic gene expressions were measured. Sprout Se content was 2.0-7.0 μg g −1 DW among the 20 mungbean germplasms. Selenium treatment differentially affected the biomass, total flavonoid, vitexin, isovitexin, antioxidant enzyme activities, and antioxidant capacities of the mungbean germplasms. Eight germplasms showed increased biomass (p < 0.05), the highest increasing by 127%, but 13 did not phenotypically respond to Se treatment. Seven and six germplasms showed varied levels of vitexin and isovitexin increment after Se treatment, the highest measuring 2.67-and 2.87-folds for vitexin and isovitexin, respectively. Two mungbean flavonoid biosynthesis genes, chalcone synthase (VrCHS) and chalcone isomerase (VrCHI) were significantly up-regulated in the germplasms with increased vitexin and isovitexin levels (p < 0.05). Moreover, Se enrichment capacity was significantly correlated with the vitexin, isovitexin, and antioxidant capacities. In conclusion, mungbean sprouts could be a useful Se-biofortified food, but the Se enrichment capacity and nutritional response must be determined for each germplasm before commercialization.

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Maclura tinctoria (L.) D. Don ex Steud. (Moraceae): a review of the advances in ethnobotanical knowledge, phytochemical composition, and pharmacological potential

Quintero-Rincón,

Pájaro-González,

Diaz-Castillo

2024

ADV TRADIT MED (ADTM)

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Maclura tinctoria (Moraceae), commonly known as dinde, is a lactescent tree of significant economic importance with extensive ethnomedicinal and ethnobotanical applications. Among native populations in the Neotropics, dinde is used to address diverse forms of inflammatory arthritis, along with ailments stemming from viral, bacterial, or fungal origins. Its efficacy stands out notably in the treatment of conditions affecting the buccal cavity, respiratory tract, and venereal infections. These medicinal attributes have spurred investigations into their potential for developing nutraceuticals and pharmacological agents. Also, dinde has a commercial appeal intertwined with the remarkable qualities of its wood, which include the resistance to moisture and termites. This review consolidates information encompassing peer-reviewed articles from major scientific databases such as Science Direct, Scopus, Springer, PubMed, and Google Scholar. The review spans fifty-four phytocompounds, characterized by remarkable structural complexity and identified from the year 2000 onward. These compounds are categorized into flavones, isoflavones, flavonols, flavanols, flavanones, chalcones, and xanthones, where a significant portion exhibiting glycosylation or prenylation. Additionally, phenolic acids and condensed tannins contribute to the chemical diversity of this species. This comprehensive review offers updated insights into the potential bioactivity of chemical constituents identified in this plant, elucidating findings derived from different studies employing both in vitro and in vivo assays. Graphical abstract

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The effect of isovitexin on lipopolysaccharide-induced renal injury and inflammation by induction of protective autophagy

Cited by 7 publications

References 67 publications

Isovitexin, the main phytoconstituent of Anthocleista djalonensis, may be responsible for the plant's antimalarial properties

Isovitexin, the main phytoconstituent of Anthocleista djalonensis, may be responsible for the plant's antimalarial properties

Selenium Differentially Regulates Flavonoid Accumulation and Antioxidant Capacities in Sprouts of Twenty Diverse Mungbean ( (L.) Wilczek) Genotypes

Maclura tinctoria (L.) D. Don ex Steud. (Moraceae): a review of the advances in ethnobotanical knowledge, phytochemical composition, and pharmacological potential

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