The effect of intravenous magnesium administration on aortic, right atrial and coronary perfusion pressures during CPR in swine

Evidence Suggesting the Beneficial use of Magnesium in Cerebral Ischaemia in an Experimental Model of Cardiac Arrest

“…However, in these studies the quality of chest compressions was not standardized adding a significant bias in their results. The use of magnesium has not been proven to exert any marked effects on diastolic aortic pressure and CPP [40]. This was further confirmed by this experimental model where no significant difference was marked with the addition of magnesium.…”

Evidence Suggesting the Beneficial use of Magnesium in Cerebral Ischaemia in an Experimental Model of Cardiac Arrest

“…However, in these studies the quality of chest compressions was not standardized adding a significant bias in their results. The use of magnesium has not been proven to exert any marked effects on diastolic aortic pressure and CPP [40]. This was further confirmed by this experimental model where no significant difference was marked with the addition of magnesium.…”

Place of magnesium sulfate in cardiopulmonary resuscitation. A systematic review and meta-analysis

“…Magnesium ions, as already mentioned in the introduction, influence the activity of enzymes regulating carbohydrate metabolism and modulate the supply of glucose to nerve cells. Magnesium ions also have a stabilizing effect on the cell membranes of thrombocytes, thus reducing platelet aggregation [24,25].…”

A randomised trial to investigate the efficacy of magnesium sulphate for refractory ventricular fibrillation

“…A higher bolus dose of magnesium may however cause side effects. In a dog model, 26 high dose magnesium of 0.14 g/kg (equivalent to 40 mmol in a 75 kg man) produced a reduction in the aortic diastolic and coronary perfusion pressures. This dosing regimen was probably too high to be clinically applicable.…”

Evidence Suggesting the Beneficial use of Magnesium in Cerebral Ischaemia in an Experimental Model of Cardiac Arrest

“…However, in these studies the quality of chest compressions was not standardized adding a significant bias in their results. The use of magnesium has not been proven to exert any marked effects on diastolic aortic pressure and CPP [40]. This was further confirmed by this experimental model where no significant difference was marked with the addition of magnesium.…”

Place of magnesium sulfate in cardiopulmonary resuscitation. A systematic review and meta-analysis

“…Magnesium ions, as already mentioned in the introduction, influence the activity of enzymes regulating carbohydrate metabolism and modulate the supply of glucose to nerve cells. Magnesium ions also have a stabilizing effect on the cell membranes of thrombocytes, thus reducing platelet aggregation [24,25].…”

A randomised trial to investigate the efficacy of magnesium sulphate for refractory ventricular fibrillation

“…A higher bolus dose of magnesium may however cause side effects. In a dog model, 26 high dose magnesium of 0.14 g/kg (equivalent to 40 mmol in a 75 kg man) produced a reduction in the aortic diastolic and coronary perfusion pressures. This dosing regimen was probably too high to be clinically applicable.…”

Evidence Suggesting the Beneficial use of Magnesium in Cerebral Ischaemia in an Experimental Model of Cardiac Arrest

“…However, in these studies the quality of chest compressions was not standardized adding a significant bias in their results. The use of magnesium has not been proven to exert any marked effects on diastolic aortic pressure and CPP [40]. This was further confirmed by this experimental model where no significant difference was marked with the addition of magnesium.…”

Place of magnesium sulfate in cardiopulmonary resuscitation. A systematic review and meta-analysis

“…Magnesium ions, as already mentioned in the introduction, influence the activity of enzymes regulating carbohydrate metabolism and modulate the supply of glucose to nerve cells. Magnesium ions also have a stabilizing effect on the cell membranes of thrombocytes, thus reducing platelet aggregation [24,25].…”

A randomised trial to investigate the efficacy of magnesium sulphate for refractory ventricular fibrillation

“…A higher bolus dose of magnesium may however cause side effects. In a dog model, 26 high dose magnesium of 0.14 g/kg (equivalent to 40 mmol in a 75 kg man) produced a reduction in the aortic diastolic and coronary perfusion pressures. This dosing regimen was probably too high to be clinically applicable.…”