The Effect of Interferon on the Synthesis of RNA in Chick Cells Infected with Semliki Forest Virus

Semliki Forest virus strongly reduces mosquito host defence signaling

“…5, bacterial stimulation reduced viral genome copy number by 40–60% (compared to non‐stimulated cells), similar to the reduction in viral gene expression, demonstrating that bacterial activation of cellular defences interferes with virus RNA replication. The magnitude of this effect is similar to the effect of type I interferon on SFV RNA synthesis in vertebrate cells (Mecs et al ., 1967).…”

Mechanisms of persistent infections by cytopathic viruses in tissue culture

“…While the most important effect of interferon on vaeeinia virus infected mouse and chick cells is to inhibit a step between virus-directed transcription and translation, SV40 early RNA synthesis was greatly inhibited by interferon treatment of BSC cells (9). Semliki forest virus replication, on the other hand, was inhibited by interferon at the level of early viral protein synthesis (38). In cell-free systems, extracts from interferon-treated cells do not translate virus genetic information as well as do extracts from untreated cells.…”

Effect of Interferon on the Replication of Sendai Virus

“…Interferon inhibits the synthesis both of infectious virus RNA (Wagner, I96I;De Somer et al 1962;Lockart, Sreevalsan & Horn, i962;Gordon et al, ~966;M~cs et al I967) and of species of virus-specific RNA detected by labelling with radioactive RNA precursors (Friedman & Sonnabend, 1965;Gordon et al I966;M~cs et al 1967) in cells infected with several small RNA viruses. It also prevents the appearance not only of the virus RNA polymerase in cells infected with Mengo virus (Miner,Ray & Simon,I966) or Semliki Forest virus (Sonnabend et al I967) but also other virus-specific proteins in Semliki Forest virus infection (Friedman, 2968).…”