The Effect of Inhalant Organic Dust on Bone Health

Carrington, Joseph; Poole, Jill

doi:10.1007/s11882-018-0773-y

Cited by 6 publications

(5 citation statements)

References 80 publications

(130 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequently, the roles of TLR9 [17], TLR2 [18], NOD2 [19], MyD88 [20], and protein kinase C epsilon (PKC ε) in organic dust-induced airway inflammation have been demonstrated. OD exposure has also been linked to bone loss indicating the systemic effects of exposure [21] (reviewed in [22]). These studies and our previous work (reviewed in [2]) demonstrate that OD is complex in composition and inhaled OD elicits host response through multiple signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling

et al. 2019

View full text Add to dashboard Cite

Background Animal production workers are persistently exposed to organic dust and can suffer from a variety of respiratory disease symptoms and annual decline in lung function. The role of high mobility group box-1 (HMGB1) in inflammatory airway diseases is emerging. Hence, we tested a hypothesis that organic dust exposure of airway epithelial cells induces nucleocytoplasmic translocation of HMGB1 and blocking this translocation dampens organic dust-induced lung inflammation. Methods Rats were exposed to either ambient air or swine barn (8 h/day for either 1, 5, or 20 days) and lung tissues were processed for immunohistochemistry. Swine barn dust was collected and organic dust extract (ODE) was prepared and sterilized. Human airway epithelial cell line (BEAS-2B) was exposed to either media or organic dust extract followed by treatment with media or ethyl pyruvate (EP) or anti-HMGB1 antibody. Immunoblotting, ELISA and other assays were performed at 0 (control), 6, 24 and 48 h. Data (as mean ± SEM) was analyzed using one or two-way ANOVA followed by Bonferroni’s post hoc comparison test. A p value of less than 0.05 was considered significant. Results Compared to controls, barn exposed rats showed an increase in the expression of HMGB1 in the lungs. Compared to controls, ODE exposed BEAS-2B cells showed nucleocytoplasmic translocation of HMGB1, co-localization of HMGB1 and RAGE, reactive species and pro-inflammatory cytokine production. EP treatment reduced the ODE induced nucleocytoplasmic translocation of HMGB1, HMGB1 expression in the cytoplasmic fraction, GM-CSF and IL-1β production and augmented the production of TGF-β1 and IL-10. Anti-HMGB1 treatment reduced ODE-induced NF-κB p65 expression, IL-6, ROS and RNS but augmented TGF-β1 and IL-10 levels. Conclusions HMGB1-RAGE signaling is an attractive target to abrogate OD-induced lung inflammation.

show abstract

Section: Introductionmentioning

confidence: 99%

Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The ozone stimulates TLR4 and inducible nitric oxide synthase, which is related to lung hyperpermeability [122,123]. The organic dust extract-induced lung inflammation, systemic response, and bone loss are associated with LPS and TLR4-signaling [124]. TLR5 has been shown to associate with the TLR4 complex and promote MYD88dependent environmental lung injury [125].…”

Section: Lung Injury and Permeability Through Activation Of Tlr4 By E...mentioning

confidence: 99%

Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury

et al. 2022

View full text Add to dashboard Cite

Lung epithelium is constantly exposed to the environment and is critically important for the orchestration of initial responses to infectious organisms, toxins, and allergic stimuli, and maintenance of normal gaseous exchange and pulmonary function. The integrity of lung epithelium, fluid balance, and transport of molecules is dictated by the tight junctions (TJs). The TJs are formed between adjacent cells. We have focused on the topic of the TJ structure and function in lung epithelial cells. This review includes a summary of the last twenty years of literature reports published on the disrupted TJs and epithelial barrier in various lung conditions and expression and regulation of specific TJ proteins against pathogenic stimuli. We discuss the molecular signaling and crosstalk among signaling pathways that control the TJ structure and function. The Toll-like receptor-4 (TLR4) recognizes the pathogen-and damage-associated molecular patterns released during lung injury and inflammation and coordinates cellular responses. The molecular aspects of TLR4 signaling in the context of TJs or the epithelial barrier are not fully known. We describe the current knowledge and possible networking of the TLR4-signaling with cellular and molecular mechanisms of TJs, lung epithelial barrier function, and resistance to treatment strategies.

show abstract

“…Work accidents of various kinds occur throughout the agricultural sector and range from those occurring on family farms, where the habitual residence is at the farm site and where the infrastructure is deficient [30], to those associated with the handling of organic remains that can cause bone diseases as a result of inhaling organic dust with microbial components [31,32].…”

Section: Introductionmentioning

confidence: 99%

Musculoskeletal Disorders in Agriculture: A Review from Web of Science Core Collection

et al. 2021

View full text Add to dashboard Cite

Agricultural workers suffer from many work-related illnesses. Some of the most common include musculoskeletal disorders (MSDs). These types of disorders are caused by diverse factors. This research study intends to demonstrate the worldwide concern for MSD in agriculture. The objective is to compile and recognize in detail all the available studies on musculoskeletal disorders in agriculture developed in the world and by countries in the last 26 years. The Web of Science database was used for this purpose. Two hundred and fifty-six documents were found, of which 221 were finally selected for inclusion in the study. The studies span a period from 1995 to 2020. Of these, studies that were linked to improving sustainability stood out. Most of the research of this type emanates from developed countries. The conclusions to be drawn are that few countries pay attention to this area and that preventive measures are insufficient. Mechanization and improvement in work methods and organization are methods to reduce risks.

show abstract

The Effect of Inhalant Organic Dust on Bone Health

Cited by 6 publications

References 80 publications

Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling

Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling

Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury

Musculoskeletal Disorders in Agriculture: A Review from Web of Science Core Collection

Contact Info

Product

Resources

About