The effect of homocysteine thiolactone and its α-alkylated derivative on the survival of irradiated E. coli AB1157

Mao, Yulu; Lübec, Gert; Getoff, N.; Solar, Sonja; Quint, Ruth

doi:10.1016/0969-806x(94)90043-4

Radiation Physics and Chemistry

1994

DOI: 10.1016/0969-806x(94)90043-4

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The effect of homocysteine thiolactone and its α-alkylated derivative on the survival of irradiated E. coli AB1157

Yulu Mao

Gert Lübec

N. Getoff

et al.

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Cited by 8 publications

References 14 publications

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Growth promotion by homocysteine thiolactone and its alpha-alkylated derivative ? A role for excess growth in homocystinurias?

Lubec¹,

Szekeres

1994

Amino Acids

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It is controversial whether homocysteic acid or other homocysteine derivatives show growth promoting effects. In a clonogenic assay we could show that homocysteine thiolactone and its alpha alkylated derivative increased colony formation significantly. Our work favorizes previous observations showing growth promoting activity of homocysteine derivatives and encourages further studies on that subject with implications for growth in physioogy and under pathological conditions.

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Growth promotion by homocysteine thiolactone and its alpha-alkylated derivative ? A role for excess growth in homocystinurias?

Lubec¹,

Szekeres

1994

Amino Acids

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Saving animal lives by tests on bacteria

Lubec

Getoff

1994

Amino Acids

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Alpha-methyl-homocysteine thiolactone protects trachea and lung of BALB/c mice irradiated with 6 Gy ? A qualitative morphological study

1994

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Alpha-methyl-homocysteine thiolactone (AMHCTL) was shown to increase survival of irradiated bacteria. Based upon these observations we administered 100 mg/kg body weight intraperitoneally female BALB/c mice prior to whole body irradiation from a Co-source at a dose of 6 Gy. Unirradiated mice as well as irradiated and L-cysteine and saline pretreated mice served as controls. Light microscopical, scanning electron microscopical and transmission electron microscopical examinations showed a radioprotective effect: Tracheal epithelium including ciliae were preserved in the experimental group, studies on the lung revealed radiationprotection as no transudation or exsudation and no proliferation of capillaries was detected.

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The effect of homocysteine thiolactone and its α-alkylated derivative on the survival of irradiated E. coli AB1157

Cited by 8 publications

References 14 publications

Growth promotion by homocysteine thiolactone and its alpha-alkylated derivative ? A role for excess growth in homocystinurias?

Growth promotion by homocysteine thiolactone and its alpha-alkylated derivative ? A role for excess growth in homocystinurias?

Saving animal lives by tests on bacteria

Alpha-methyl-homocysteine thiolactone protects trachea and lung of BALB/c mice irradiated with 6 Gy ? A qualitative morphological study

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