The effect of high intensity physical exercise and hypoxia on glycemia, angiogenic biomarkers and cardiorespiratory function in patients with type 1 diabetes

Żebrowska, Aleksandra; Hall, Barbara; Kochańska-Dziurowicz, A; Janikowska, Grażyna

doi:10.17219/acem/66354

Cited by 23 publications

(15 citation statements)

References 30 publications

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“…When drawing conclusions and making comparisons from some of the differences found in the literature regarding these effects, it must be considered that the regimen and the degree of hypoxia will lead to variation in the results ( Debevec and Millet, 1985 ); however, most of these studies tend to agree in showing that under hypoxia, glucose regulation is improved in both rats and humans ( Sawhney et al, 1986 ; Larsen et al, 1997 ; Woolcott et al, 2015 ; Sacramento et al, 2016 ). Moreover, this glucose improvement under different regimens of hypoxia would take some time and reach a plateau in the long term, resulting in rather normal value as observed in human studies ( Woolcott et al, 2015 ; Żebrowska et al, 2018 ) and in rats ( Chen et al, 2016 ). Therefore, the improved glucose regulation in rats under long-term CIH in this study supports the contribution of hypoxia to these phenomena and, to our knowledge, has not been previously reported.…”

Section: Discussionmentioning

confidence: 91%

Long-Term Chronic Intermittent Hypobaric Hypoxia Induces Glucose Transporter (GLUT4) Translocation Through AMP-Activated Protein Kinase (AMPK) in the Soleus Muscle in Lean Rats

et al. 2018

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Background: In chronic hypoxia (CH) and short-term chronic intermittent hypoxia (CIH) exposure, glycemia and insulin levels decrease and insulin sensitivity increases, which can be explained by changes in glucose transport at skeletal muscles involving GLUT1, GLUT4, Akt, and AMPK, as well as GLUT4 translocation to cell membranes. However, during long-term CIH, there is no information regarding whether these changes occur similarly or differently than in other types of hypoxia exposure. This study evaluated the levels of AMPK and Akt and the location of GLUT4 in the soleus muscles of lean rats exposed to long-term CIH, CH, and normoxia (NX) and compared the findings.Methods: Thirty male adult rats were randomly assigned to three groups: a NX (760 Torr) group (n = 10), a CIH group (2 days hypoxia/2 days NX; n = 10) and a CH group (n = 10). Rats were exposed to hypoxia for 30 days in a hypobaric chamber set at 428 Torr (4,600 m). Feeding (10 g daily) and fasting times were accurately controlled. Measurements included food intake (every 4 days), weight, hematocrit, hemoglobin, glycemia, serum insulin (by ELISA), and insulin sensitivity at days 0 and 30. GLUT1, GLUT4, AMPK levels and Akt activation in rat soleus muscles were determined by western blot. GLUT4 translocation was measured with confocal microscopy at day 30.Results: (1) Weight loss and increases in hematocrit and hemoglobin were found in both hypoxic groups (p < 0.05). (2) A moderate decrease in glycemia and plasma insulin was found. (3) Insulin sensitivity was greater in the CIH group (p < 0.05). (4) There were no changes in GLUT1, GLUT4 levels or in Akt activation. (5) The level of activated AMPK was increased only in the CIH group (p < 0.05). (6) Increased GLUT4 translocation to the plasma membrane of soleus muscle cells was observed in the CIH group (p < 0.05).Conclusion: In lean rats experiencing long-term CIH, glycemia and insulin levels decrease and insulin sensitivity increases. Interestingly, there is no increase of GLUT1 or GLUT4 levels or in Akt activation. Therefore, cellular regulation of glucose seems to primarily involve GLUT4 translocation to the cell membrane in response to hypoxia-mediated AMPK activation.

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Section: Discussionmentioning

confidence: 91%

Long-Term Chronic Intermittent Hypobaric Hypoxia Induces Glucose Transporter (GLUT4) Translocation Through AMP-Activated Protein Kinase (AMPK) in the Soleus Muscle in Lean Rats

et al. 2018

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“…Duennwald et al [28] demonstrated that T1D individuals exposed to intermittent hypoxia (FiO₂ = 13.0 %) (5 × 6 min each day over 1-3 weeks) had improved ventilatory reflexes to Hx. The study by Zebrowska et al [29] showed that shorttime hypoxia (FiO₂ = 15.1 %) combined with graded exercise allowed more effective glycaemia control in T1D patients when compared with the exercise in normoxia. Submaximal exercise with hypoxia (FiO₂ = 14.0 %) may induce up-regulation of serum pro-angiogenic regulators compared to normoxia in T2D [23].…”

Section: Effects Of Hypoxia During Continuous and Intermittent Exercimentioning

confidence: 99%

Effects of Hypoxia during Continuous and Intermittent Exercise on Glycaemic Control and Selected Markers of Vascular Function in Type 1 Diabetes

Hall

Żebrowska

Kamiński

et al. 2017

Exp Clin Endocrinol Diabetes

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“…Многие авторы допускают, что эффективным способом увеличения выживаемости человека в усло виях острой гипоксической гипоксии является ограничение физической активности, что лимитирует расход доступного для дыхания кислорода и субстратов биологического окисления [18,19,23]. При этом снижение метаболизма также может быть достигнуто за счет применения фармакологических веществ из класса антигипоксантов.…”

Section: Keywtrbunclassified

Comparative analysis of metal-complex and aminothiol antihypoxants efficiencies in the experiment

Евсеев

Викторович²,

Surmenev

et al. 2018

Rev Clin Pharm Drug Ther

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Aim. Comparative analysis of the efficiency of metal-complex (πQ1983, πQ2721) and aminothiol (Amtizole, Sunazole) antihypoxants in experiments on rats exposed to acute hypoxia with hypercapnia. Methods. Experiments performed on 182 male rats of Wistar line weighing 150-170 g. The study of antihypoxic activity of substances was carried out on the model the AH+Hc. The condition of acute hypoxia in rats was formed by placing them in glass airtight containers with a free volume of 1.0 L. Antihypoxic effect was evaluated by the life expectancy of animals in the described conditions. Substances πQ2721, πQ1983, Amtizole and Sunazole was administered once intraperitoneally at doses of 25, 50 and 100 mg/kg. Previously each substance was dissolved in 0.9% NaCl (1.0 ml). Testing the effectiveness of the substances on AH+Hc model was carried out after 1 h after administration of the substances and after 24 h. Animals of control groups were injected with 1.0 ml of 0.9% NaCl. In animals exposed to test AH+Hc in 1 h after administration were performed measurements of the rectal temperature before the experiment and through 1 h after administration, i.e. before AH+Hc. In animals selected for 24-hour observation, rectal temperature was measured before the experiment, and then after 1, 3, 6, 12, 18 and 24 h of observation, after which they were exposed to AH+Hc. Results. The antihypoxic effect of a selenium-containing substance πQ2721 based on Zn2+ was confirmed in experiments on rats. In a number of substances for comparison the πQ2721 proved himself not only as equally effective. It is found that after 1 h after administration at a dose of 50 mg/kg πQ2721 superior to all studied compounds, including antihypoxant with succinate Sunazole. An important advantage of the new promising antihypoxic agent was the preservation of its action for 24 hours after injection. (For citation: Evseev AV, Surmenev DV, Evseeva MA, et al. Comparative analysis of metal-complex and aminothiol antihypoxants efficiencies in the experiment. Reviews on Clinical Pharmacology and Drug Therapy. 2018;16(2):18-24. doi: 10.17816/RCF16218-24).

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The effect of high intensity physical exercise and hypoxia on glycemia, angiogenic biomarkers and cardiorespiratory function in patients with type 1 diabetes

Abstract: Our study demonstrated that hypoxia combined with exercise reduces glycemia and may induce significant benefits in the prevention of diabetes cardiovascular complications.

Cited by 23 publications

References 30 publications

Long-Term Chronic Intermittent Hypobaric Hypoxia Induces Glucose Transporter (GLUT4) Translocation Through AMP-Activated Protein Kinase (AMPK) in the Soleus Muscle in Lean Rats

Long-Term Chronic Intermittent Hypobaric Hypoxia Induces Glucose Transporter (GLUT4) Translocation Through AMP-Activated Protein Kinase (AMPK) in the Soleus Muscle in Lean Rats

Effects of Hypoxia during Continuous and Intermittent Exercise on Glycaemic Control and Selected Markers of Vascular Function in Type 1 Diabetes

Comparative analysis of metal-complex and aminothiol antihypoxants efficiencies in the experiment

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